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Entry version 125 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Amino acid permease 1

Gene

AAP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Amino acid-proton symporter. Stereospecific transporter with a broad specificity for histidine, glutamate and neutral amino acids. Reduced affinities for asparagine and valine. Involved in amino acid uptake from the apoplastic cavity into the embryo cells for storage protein accumulation and in root amino acid uptake.

6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by carbonylcyanide m-chlorophenylhydrazone and diethylpyrocarbonate (DEPC).

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=292 µM for alanine3 Publications
  2. KM=60 µM for L-proline3 Publications
  3. KM=774 µM for aspartate3 Publications
  1. Vmax=0.644 nmol/min/mg enzyme toward aspartate3 Publications

pH dependencei

Optimum pH is acidic.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Symport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:AT1G58360-MONOMER

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q42400

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.18.2.1, the amino acid/auxin permease (aaap) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amino acid permease 1
Alternative name(s):
Amino acid transporter AAP1
Neutral amino acid transporter II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AAP1
Synonyms:NAT2
Ordered Locus Names:At1g58360
ORF Names:F19C14.3, ZCF54
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G58360

The Arabidopsis Information Resource

More...
TAIRi
locus:2016600, AT1G58360

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 40Cytoplasmic1 PublicationAdd BLAST40
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 129Cytoplasmic1 PublicationAdd BLAST47
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 166Extracellular1 PublicationAdd BLAST16
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 194Cytoplasmic1 Publication7
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 245Extracellular1 PublicationAdd BLAST30
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 285Cytoplasmic1 PublicationAdd BLAST19
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 318Extracellular1 PublicationAdd BLAST12
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Topological domaini340 – 394Cytoplasmic1 PublicationAdd BLAST55
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 450Cytoplasmic1 PublicationAdd BLAST14
Transmembranei451 – 471HelicalSequence analysisAdd BLAST21
Topological domaini472 – 485Extracellular1 PublicationAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No effect on plant growth or seed germination, but reduced seed weight and total seed yield. Resistant to toxic concentrations of amino acids in the growth medium.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003874991 – 485Amino acid permease 1Add BLAST485

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q42400

PRoteomics IDEntifications database

More...
PRIDEi
Q42400

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
244335

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in developing pods. Found in the endosperm and in the storage parenchyma and the outer epidermis cells of the developing embryo. Lower levels of expression in flowers, in the vascular system of the cotyledon and in the root epidermal cells, including root hairs and throughout the root tip.5 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in endosperm during early stages of seed development. Strongly induced at heart stage of embryogenesis.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q42400, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q42400, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G58360.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 23Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1303, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_031247_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q42400

Identification of Orthologs from Complete Genome Data

More...
OMAi
AVGKSNC

Database of Orthologous Groups

More...
OrthoDBi
570025at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q42400

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013057, AA_transpt_TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01490, Aa_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q42400-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSFNTEGHN HSTAESGDAY TVSDPTKNVD EDGREKRTGT WLTASAHIIT
60 70 80 90 100
AVIGSGVLSL AWAIAQLGWI AGTSILLIFS FITYFTSTML ADCYRAPDPV
110 120 130 140 150
TGKRNYTYMD VVRSYLGGRK VQLCGVAQYG NLIGVTVGYT ITASISLVAV
160 170 180 190 200
GKSNCFHDKG HTADCTISNY PYMAVFGIIQ VILSQIPNFH KLSFLSIMAA
210 220 230 240 250
VMSFTYATIG IGLAIATVAG GKVGKTSMTG TAVGVDVTAA QKIWRSFQAV
260 270 280 290 300
GDIAFAYAYA TVLIEIQDTL RSSPAENKAM KRASLVGVST TTFFYILCGC
310 320 330 340 350
IGYAAFGNNA PGDFLTDFGF FEPFWLIDFA NACIAVHLIG AYQVFAQPIF
360 370 380 390 400
QFVEKKCNRN YPDNKFITSE YSVNVPFLGK FNISLFRLVW RTAYVVITTV
410 420 430 440 450
VAMIFPFFNA ILGLIGAASF WPLTVYFPVE MHIAQTKIKK YSARWIALKT
460 470 480
MCYVCLIVSL LAAAGSIAGL ISSVKTYKPF RTMHE
Length:485
Mass (Da):52,895
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i722E3895937CCC5B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti252D → Y in AAB87674 (PubMed:8356039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L16240 mRNA Translation: AAA32726.1
AF031649 Genomic DNA Translation: AAB87674.1
X67124 mRNA Translation: CAA47603.1
AB077822 Genomic DNA Translation: BAB83868.1
AC008051 Genomic DNA Translation: AAF82252.1
CP002684 Genomic DNA Translation: AEE33541.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A48187

NCBI Reference Sequences

More...
RefSeqi
NP_176132.1, NM_104616.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G58360.1; AT1G58360.1; AT1G58360

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
842205

Gramene; a comparative resource for plants

More...
Gramenei
AT1G58360.1; AT1G58360.1; AT1G58360

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G58360

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16240 mRNA Translation: AAA32726.1
AF031649 Genomic DNA Translation: AAB87674.1
X67124 mRNA Translation: CAA47603.1
AB077822 Genomic DNA Translation: BAB83868.1
AC008051 Genomic DNA Translation: AAF82252.1
CP002684 Genomic DNA Translation: AEE33541.1
PIRiA48187
RefSeqiNP_176132.1, NM_104616.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT1G58360.1

Protein family/group databases

TCDBi2.A.18.2.1, the amino acid/auxin permease (aaap) family

Proteomic databases

PaxDbiQ42400
PRIDEiQ42400
ProteomicsDBi244335

Genome annotation databases

EnsemblPlantsiAT1G58360.1; AT1G58360.1; AT1G58360
GeneIDi842205
GrameneiAT1G58360.1; AT1G58360.1; AT1G58360
KEGGiath:AT1G58360

Organism-specific databases

AraportiAT1G58360
TAIRilocus:2016600, AT1G58360

Phylogenomic databases

eggNOGiKOG1303, Eukaryota
HOGENOMiCLU_031247_4_1_1
InParanoidiQ42400
OMAiAVGKSNC
OrthoDBi570025at2759
PhylomeDBiQ42400

Enzyme and pathway databases

BioCyciMetaCyc:AT1G58360-MONOMER
SABIO-RKiQ42400

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q42400

Gene expression databases

ExpressionAtlasiQ42400, baseline and differential
GenevisibleiQ42400, AT

Family and domain databases

InterProiView protein in InterPro
IPR013057, AA_transpt_TM
PfamiView protein in Pfam
PF01490, Aa_trans, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAAP1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q42400
Secondary accession number(s): O48546
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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