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Protein

Metallothionein-like protein 4B

Gene

MT4B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as metal chelator of copper (Cu) and zinc (Zn) (PubMed:18287486). Plays a role in storing and distributing Zn ion in seed (PubMed:22014117).Curated2 Publications

Miscellaneous

Plants silencing both MT4A and MT4B have reduced seed weight and reduced seedling growth after germination.1 Publication

GO - Molecular functioni

GO - Biological processi

  • zinc ion transport Source: TAIR

Keywordsi

LigandMetal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-like protein 4B
Short name:
MT-4B
Alternative name(s):
EC protein homolog 2
Gene namesi
Name:MT4B
Ordered Locus Names:At2g23240
ORF Names:T20D16.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G23240
TAIRilocus:2058593 AT2G23240

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001974241 – 85Metallothionein-like protein 4BAdd BLAST85

Proteomic databases

PaxDbiQ42377
PRIDEiQ42377

Expressioni

Tissue specificityi

Expressed specifically in seeds.1 Publication

Developmental stagei

During embryo development, expressed from torpedo stage (6 days after pollination) to mature embryo.1 Publication

Inductioni

By abscisic acid (ABA) and jasmonic acid. Down-regulated by gibberellin.1 Publication

Gene expression databases

ExpressionAtlasiQ42377 baseline and differential
GenevisibleiQ42377 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G23240.1

Structurei

3D structure databases

ProteinModelPortaliQ42377
SMRiQ42377
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J62V Eukaryota
ENOG410Z4N5 LUCA
HOGENOMiHOG000243560
InParanoidiQ42377
OrthoDBiEOG09360YWB
PhylomeDBiQ42377

Family and domain databases

InterProiView protein in InterPro
IPR000316 Metallthion_15
PfamiView protein in Pfam
PF02068 Metallothio_PEC, 1 hit
PRINTSiPR00877 MTPLANTPEC

Sequence (1+)i

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q42377-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADTGKGSAS ASCNDRCGCP SPCPGGESCR CKMMSEASGG DQEHNTCPCG
60 70 80
EHCGCNPCNC PKTQTQTSAK GCTCGEGCTC ATCAA
Length:85
Mass (Da):8,437
Last modified:December 1, 2000 - v2
Checksum:i3B4065F1CD427912
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4ILI2F4ILI2_ARATH
Plant EC metallothionein-like prote...
AtMT4b At2g23240, T20D16.13, T20D16_13
84Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002391 Genomic DNA Translation: AAB87107.1
CP002685 Genomic DNA Translation: AEC07432.1
Z27049 mRNA Translation: CAA81575.1
Z29896 mRNA Translation: CAA82835.1
PIRiT00508
RefSeqiNP_179905.1, NM_127888.2 [Q42377-1]
UniGeneiAt.39319

Genome annotation databases

EnsemblPlantsiAT2G23240.1; AT2G23240.1; AT2G23240 [Q42377-1]
GeneIDi816856
GrameneiAT2G23240.1; AT2G23240.1; AT2G23240 [Q42377-1]
KEGGiath:AT2G23240

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002391 Genomic DNA Translation: AAB87107.1
CP002685 Genomic DNA Translation: AEC07432.1
Z27049 mRNA Translation: CAA81575.1
Z29896 mRNA Translation: CAA82835.1
PIRiT00508
RefSeqiNP_179905.1, NM_127888.2 [Q42377-1]
UniGeneiAt.39319

3D structure databases

ProteinModelPortaliQ42377
SMRiQ42377
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G23240.1

Proteomic databases

PaxDbiQ42377
PRIDEiQ42377

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G23240.1; AT2G23240.1; AT2G23240 [Q42377-1]
GeneIDi816856
GrameneiAT2G23240.1; AT2G23240.1; AT2G23240 [Q42377-1]
KEGGiath:AT2G23240

Organism-specific databases

AraportiAT2G23240
TAIRilocus:2058593 AT2G23240

Phylogenomic databases

eggNOGiENOG410J62V Eukaryota
ENOG410Z4N5 LUCA
HOGENOMiHOG000243560
InParanoidiQ42377
OrthoDBiEOG09360YWB
PhylomeDBiQ42377

Miscellaneous databases

PROiPR:Q42377

Gene expression databases

ExpressionAtlasiQ42377 baseline and differential
GenevisibleiQ42377 AT

Family and domain databases

InterProiView protein in InterPro
IPR000316 Metallthion_15
PfamiView protein in Pfam
PF02068 Metallothio_PEC, 1 hit
PRINTSiPR00877 MTPLANTPEC
ProtoNetiSearch...

Entry informationi

Entry nameiMT4B_ARATH
AccessioniPrimary (citable) accession number: Q42377
Secondary accession number(s): Q9SLN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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