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UniProtKB - Q40255 (ALDH_LINUS)
Protein
Probable aldehyde dehydrogenase
Gene
FIS1
Organism
Linum usitatissimum (Flax) (Linum humile)
Status
Functioni
Could be involved in facilitating the biotrophic relationship between the plant and the rust fungus.
Catalytic activityi
- EC:1.2.1.3
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 203 | Transition state stabilizerBy similarity | 1 | |
Active sitei | 297 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 332 | NucleophilePROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 278 – 283 | NADBy similarity | 6 |
GO - Molecular functioni
- aldehyde dehydrogenase (NAD+) activity Source: UniProtKB-EC
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Source: UniProtKB-EC
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | Recommended name: Probable aldehyde dehydrogenase (EC:1.2.1.3)Alternative name(s): Flax-inducible sequence 1 |
Gene namesi | Name:FIS1 |
Organismi | Linum usitatissimum (Flax) (Linum humile) |
Taxonomic identifieri | 4006 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Malpighiales › Linaceae › Linum |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056433 | 1 – 551 | Probable aldehyde dehydrogenaseAdd BLAST | 551 |
Expressioni
Tissue specificityi
In uninfected plants, highest levels found in stems. In plants infected with the flax rust, highest levels in leaves. Higher levels of expression in infected leaves than uninfected stems.
Inductioni
By flax rust susceptible infection but not by resistant infection. Levels 10-fold higher in infected plants than uninfected plants.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR044638, ALDH7A1-like |
PANTHERi | PTHR43521, PTHR43521, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q40255-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYRPLVARLL RDSVATRKGS SHFARRFSHS LPFATVDAEE LSGAKPAEVL
60 70 80 90 100
NLVQGNWGGS SSWHTVVDPL NGEPFIKVAE VDETEIKPFV ESLSKCPKHG
110 120 130 140 150
LHNPFKSPER YLLYGDISTK AGHMLSIPKV SEFFARLIQR VAPKSYHQAL
160 170 180 190 200
GEVQVTQKFF ENFTGDQVRF LARSFGVPGN HLGQQSNGFR WPFGPVAIIT
210 220 230 240 250
PFNFPLEIPV LQLMGALYMG NKPLLKVDSK VSIVMEQMMR LLHYCGLPVG
260 270 280 290 300
DADFVNSDGK AMNKILLEAN PRMTLFTGSS RVAEKLALDL KGRIKLEDAG
310 320 330 340 350
FDWKILGPDV NEADYVAWVC DQDAYACSGQ KCSAQSILFM HENWAATPLI
360 370 380 390 400
SRLKELAERR KLEDLTVGPV LTVTTEAMLD HLNKLLQIPG AKLLFGGKPL
410 420 430 440 450
ENHTIPSIYG AVKPTAVYVP LEEILKVSNY ELVTKEIFGP FQVVTEYKNS
460 470 480 490 500
QLPMVLEALE RMHAHLTAAV VSNDQLFLQE VIGNTVNGTT YAGLRARTTG
510 520 530 540 550
APQNHWFGPA GDPRGAGIGT PEAIKLVWSC HREIIYDIGP VSHHWEIPPS
T
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X86733 mRNA Translation: CAA60412.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X86733 mRNA Translation: CAA60412.1 |
3D structure databases
SMRi | Q40255 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR044638, ALDH7A1-like |
PANTHERi | PTHR43521, PTHR43521, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALDH_LINUS | |
Accessioni | Q40255Primary (citable) accession number: Q40255 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | November 1, 1996 | |
Last modified: | June 2, 2021 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |