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Protein

Zinc-activated ligand-gated ion channel

Gene

ZACN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Zinc-activated ligand-gated ion channel.1 Publication

Miscellaneous

The mouse and rat orthologous proteins do not exist.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

GO - Molecular functioni

  • ligand-gated ion channel activity Source: BHF-UCL
  • serotonin-gated cation-selective channel activity Source: GO_Central
  • transmembrane signaling receptor activity Source: InterPro
  • zinc ion binding Source: HGNC

GO - Biological processi

  • ion transmembrane transport Source: BHF-UCL
  • response to zinc ion Source: HGNC

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandZinc

Protein family/group databases

TCDBi1.A.9.2.4 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-activated ligand-gated ion channel
Alternative name(s):
Ligand-gated ion channel zinc-activated 1
Ligand-gated ion-channel receptor L2
Gene namesi
Name:ZACN
Synonyms:L2, LGICZ, LGICZ1, ZAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000186919.12
HGNCiHGNC:29504 ZACN
MIMi610935 gene
neXtProtiNX_Q401N2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 233ExtracellularSequence analysisAdd BLAST208
Transmembranei234 – 254Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini255 – 265CytoplasmicSequence analysisAdd BLAST11
Transmembranei266 – 286Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini287 – 298ExtracellularSequence analysisAdd BLAST12
Transmembranei299 – 319Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini320 – 368CytoplasmicSequence analysisAdd BLAST49
Transmembranei369 – 389Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini390 – 412ExtracellularSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi353174
OpenTargetsiENSG00000186919
PharmGKBiPA162409377

Chemistry databases

GuidetoPHARMACOLOGYi587

Polymorphism and mutation databases

BioMutaiZACN
DMDMi166991030

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000031716526 – 412Zinc-activated ligand-gated ion channelAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 171By similarity
GlycosylationiPRO_5000052473170N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ401N2
PeptideAtlasiQ401N2
PRIDEiQ401N2
ProteomicsDBi61925
61926 [Q401N2-2]
61927 [Q401N2-3]
TopDownProteomicsiQ401N2-3 [Q401N2-3]

PTM databases

iPTMnetiQ401N2

Expressioni

Tissue specificityi

Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.2 Publications

Gene expression databases

BgeeiENSG00000186919
CleanExiHS_ZACN
GenevisibleiQ401N2 HS

Interactioni

Protein-protein interaction databases

BioGridi131658, 71 interactors
STRINGi9606.ENSP00000334854

Structurei

3D structure databases

ProteinModelPortaliQ401N2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi224 – 318Leu-richAdd BLAST95

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKFM Eukaryota
ENOG4111421 LUCA
GeneTreeiENSGT00920000149199
HOGENOMiHOG000155757
HOVERGENiHBG108756
InParanoidiQ401N2
KOiK16888
OMAiLVPCFQV
OrthoDBiEOG091G0CPT
PhylomeDBiQ401N2
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q401N2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMALWSLLHL TFLGFSITLL LVHGQGFQGT AAIWPSLFNV NLSKKVQESI
60 70 80 90 100
QIPNNGSAPL LVDVRVFVSN VFNVDILRYT MSSMLLLRLS WLDTRLAWNT
110 120 130 140 150
SAHPRHAITL PWESLWTPRL TILEALWVDW RDQSPQARVD QDGHVKLNLA
160 170 180 190 200
LATETNCNFE LLHFPRDHSN CSLSFYALSN TAMELEFQAH VVNEIVSVKR
210 220 230 240 250
EYVVYDLKTQ VPPQQLVPCF QVTLRLKNTA LKSIIALLVP AEALLLADVC
260 270 280 290 300
GGLLPLRAIE RIGYKVTLLL SYLVLHSSLV QALPSSSSCN PLLIYYFTIL
310 320 330 340 350
LLLLFLSTIE TVLLAGLLAR GNLGAKSGPS PAPRGEQREH GNPGPHPAEE
360 370 380 390 400
PSRGVKGSQR SWPETADRIF FLVYVVGVLC TQFVFAGIWM WAACKSDAAP
410
GEAAPHGRRP RL
Length:412
Mass (Da):45,816
Last modified:February 5, 2008 - v2
Checksum:iB894A28F5163723F
GO
Isoform 2 (identifier: Q401N2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-266: AMELEFQAHV...RAIERIGYKV → GADRAGAAGL...VLSGSLRAPL
     267-412: Missing.

Show »
Length:266
Mass (Da):29,616
Checksum:i06C2C8684090C9C8
GO
Isoform 3 (identifier: Q401N2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-126: DILRYTMSSM...TPRLTILEAL → SSVLPRATAL...PPCINPSGDI
     127-412: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:126
Mass (Da):13,299
Checksum:i9F87FF81BAB98B5F
GO

Sequence cautioni

The sequence AAI10598 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO20969 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW89365 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038483152A → T2 PublicationsCorresponds to variant dbSNP:rs2257020Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03090975 – 126DILRY…ILEAL → SSVLPRATALHSHGDCSGSA PCSKARGSGCHGLTPGNHLK VQPPCINPSGDI in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_030910127 – 412Missing in isoform 3. 1 PublicationAdd BLAST286
Alternative sequenceiVSP_030911182 – 266AMELE…IGYKV → GADRAGAAGLRRGGGRWGRG TPRSVVQGQGAGQGEGAKAD RRRTPRSVFRAVYPRLRRAA PALPLRPPLEWQPISVLSGS LRAPL in isoform 2. 2 PublicationsAdd BLAST85
Alternative sequenceiVSP_030912267 – 412Missing in isoform 2. 2 PublicationsAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF512521 mRNA Translation: AAO20969.1 Different initiation.
AB223030 mRNA Translation: BAE19924.1
AK122638 mRNA No translation available.
AC018665 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89365.1 Different initiation.
CH471099 Genomic DNA Translation: EAW89366.1
BC110596 mRNA No translation available.
BC110597 mRNA Translation: AAI10598.1 Different initiation.
CCDSiCCDS11740.2 [Q401N2-1]
RefSeqiNP_851321.2, NM_180990.3 [Q401N2-1]
UniGeneiHs.714919

Genome annotation databases

EnsembliENST00000334586; ENSP00000334854; ENSG00000186919 [Q401N2-1]
ENST00000421794; ENSP00000391936; ENSG00000186919 [Q401N2-3]
ENST00000425015; ENSP00000397489; ENSG00000186919 [Q401N2-2]
GeneIDi353174
KEGGihsa:353174
UCSCiuc002jqn.3 human [Q401N2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZACN_HUMAN
AccessioniPrimary (citable) accession number: Q401N2
Secondary accession number(s): Q2TB29, Q6ZWK3, Q86YW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 20, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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