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Protein

Zinc-activated ligand-gated ion channel

Gene

ZACN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Zinc-activated ligand-gated ion channel.1 Publication

Miscellaneous

The mouse and rat orthologous proteins do not exist.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular ligand-gated ion channel activity Source: InterPro
  • ligand-gated ion channel activity Source: BHF-UCL
  • transmembrane signaling receptor activity Source: InterPro
  • zinc ion binding Source: HGNC

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandZinc

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.9.2.4 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc-activated ligand-gated ion channel
Alternative name(s):
Ligand-gated ion channel zinc-activated 1
Ligand-gated ion-channel receptor L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZACN
Synonyms:L2, LGICZ, LGICZ1, ZAC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186919.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29504 ZACN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610935 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q401N2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 233ExtracellularSequence analysisAdd BLAST208
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei234 – 254Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini255 – 265CytoplasmicSequence analysisAdd BLAST11
Transmembranei266 – 286Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini287 – 298ExtracellularSequence analysisAdd BLAST12
Transmembranei299 – 319Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini320 – 368CytoplasmicSequence analysisAdd BLAST49
Transmembranei369 – 389Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini390 – 412ExtracellularSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
353174

Open Targets

More...
OpenTargetsi
ENSG00000186919

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162409377

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
587

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZACN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166991030

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031716526 – 412Zinc-activated ligand-gated ion channelAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi157 ↔ 171By similarity
GlycosylationiPRO_5000052473170N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q401N2

PeptideAtlas

More...
PeptideAtlasi
Q401N2

PRoteomics IDEntifications database

More...
PRIDEi
Q401N2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61925
61926 [Q401N2-2]
61927 [Q401N2-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q401N2-3 [Q401N2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q401N2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186919 Expressed in 92 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZACN

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q401N2 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131658, 71 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334854

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q401N2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi224 – 318Leu-richAdd BLAST95

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKFM Eukaryota
ENOG4111421 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00920000149199

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000155757

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108756

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q401N2

KEGG Orthology (KO)

More...
KOi
K16888

Identification of Orthologs from Complete Genome Data

More...
OMAi
SRRSWAE

Database of Orthologous Groups

More...
OrthoDBi
1001614at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q401N2

TreeFam database of animal gene trees

More...
TreeFami
TF315605

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.170.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR018000 Neurotransmitter_ion_chnl_CS

The PANTHER Classification System

More...
PANTHERi
PTHR18945 PTHR18945, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02931 Neur_chan_LBD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q401N2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMALWSLLHL TFLGFSITLL LVHGQGFQGT AAIWPSLFNV NLSKKVQESI
60 70 80 90 100
QIPNNGSAPL LVDVRVFVSN VFNVDILRYT MSSMLLLRLS WLDTRLAWNT
110 120 130 140 150
SAHPRHAITL PWESLWTPRL TILEALWVDW RDQSPQARVD QDGHVKLNLA
160 170 180 190 200
LATETNCNFE LLHFPRDHSN CSLSFYALSN TAMELEFQAH VVNEIVSVKR
210 220 230 240 250
EYVVYDLKTQ VPPQQLVPCF QVTLRLKNTA LKSIIALLVP AEALLLADVC
260 270 280 290 300
GGLLPLRAIE RIGYKVTLLL SYLVLHSSLV QALPSSSSCN PLLIYYFTIL
310 320 330 340 350
LLLLFLSTIE TVLLAGLLAR GNLGAKSGPS PAPRGEQREH GNPGPHPAEE
360 370 380 390 400
PSRGVKGSQR SWPETADRIF FLVYVVGVLC TQFVFAGIWM WAACKSDAAP
410
GEAAPHGRRP RL
Length:412
Mass (Da):45,816
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB894A28F5163723F
GO
Isoform 2 (identifier: Q401N2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-266: AMELEFQAHV...RAIERIGYKV → GADRAGAAGL...VLSGSLRAPL
     267-412: Missing.

Show »
Length:266
Mass (Da):29,616
Checksum:i06C2C8684090C9C8
GO
Isoform 3 (identifier: Q401N2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-126: DILRYTMSSM...TPRLTILEAL → SSVLPRATAL...PPCINPSGDI
     127-412: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:126
Mass (Da):13,299
Checksum:i9F87FF81BAB98B5F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI10598 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO20969 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW89365 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038483152A → T2 PublicationsCorresponds to variant dbSNP:rs2257020Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03090975 – 126DILRY…ILEAL → SSVLPRATALHSHGDCSGSA PCSKARGSGCHGLTPGNHLK VQPPCINPSGDI in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_030910127 – 412Missing in isoform 3. 1 PublicationAdd BLAST286
Alternative sequenceiVSP_030911182 – 266AMELE…IGYKV → GADRAGAAGLRRGGGRWGRG TPRSVVQGQGAGQGEGAKAD RRRTPRSVFRAVYPRLRRAA PALPLRPPLEWQPISVLSGS LRAPL in isoform 2. 2 PublicationsAdd BLAST85
Alternative sequenceiVSP_030912267 – 412Missing in isoform 2. 2 PublicationsAdd BLAST146

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF512521 mRNA Translation: AAO20969.1 Different initiation.
AB223030 mRNA Translation: BAE19924.1
AK122638 mRNA No translation available.
AC018665 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89365.1 Different initiation.
CH471099 Genomic DNA Translation: EAW89366.1
BC110596 mRNA No translation available.
BC110597 mRNA Translation: AAI10598.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11740.2 [Q401N2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_851321.2, NM_180990.3 [Q401N2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.714919

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334586; ENSP00000334854; ENSG00000186919 [Q401N2-1]
ENST00000421794; ENSP00000391936; ENSG00000186919 [Q401N2-3]
ENST00000425015; ENSP00000397489; ENSG00000186919 [Q401N2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
353174

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:353174

UCSC genome browser

More...
UCSCi
uc002jqn.3 human [Q401N2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF512521 mRNA Translation: AAO20969.1 Different initiation.
AB223030 mRNA Translation: BAE19924.1
AK122638 mRNA No translation available.
AC018665 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89365.1 Different initiation.
CH471099 Genomic DNA Translation: EAW89366.1
BC110596 mRNA No translation available.
BC110597 mRNA Translation: AAI10598.1 Different initiation.
CCDSiCCDS11740.2 [Q401N2-1]
RefSeqiNP_851321.2, NM_180990.3 [Q401N2-1]
UniGeneiHs.714919

3D structure databases

ProteinModelPortaliQ401N2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131658, 71 interactors
STRINGi9606.ENSP00000334854

Chemistry databases

GuidetoPHARMACOLOGYi587

Protein family/group databases

TCDBi1.A.9.2.4 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

PTM databases

iPTMnetiQ401N2

Polymorphism and mutation databases

BioMutaiZACN
DMDMi166991030

Proteomic databases

PaxDbiQ401N2
PeptideAtlasiQ401N2
PRIDEiQ401N2
ProteomicsDBi61925
61926 [Q401N2-2]
61927 [Q401N2-3]
TopDownProteomicsiQ401N2-3 [Q401N2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334586; ENSP00000334854; ENSG00000186919 [Q401N2-1]
ENST00000421794; ENSP00000391936; ENSG00000186919 [Q401N2-3]
ENST00000425015; ENSP00000397489; ENSG00000186919 [Q401N2-2]
GeneIDi353174
KEGGihsa:353174
UCSCiuc002jqn.3 human [Q401N2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
353174
DisGeNETi353174
EuPathDBiHostDB:ENSG00000186919.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZACN

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0027141
HGNCiHGNC:29504 ZACN
MIMi610935 gene
neXtProtiNX_Q401N2
OpenTargetsiENSG00000186919
PharmGKBiPA162409377

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IKFM Eukaryota
ENOG4111421 LUCA
GeneTreeiENSGT00920000149199
HOGENOMiHOG000155757
HOVERGENiHBG108756
InParanoidiQ401N2
KOiK16888
OMAiSRRSWAE
OrthoDBi1001614at2759
PhylomeDBiQ401N2
TreeFamiTF315605

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZACN human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Zinc-activated_ion_channel

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
353174

Protein Ontology

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PROi
PR:Q401N2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000186919 Expressed in 92 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_ZACN
GenevisibleiQ401N2 HS

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZACN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q401N2
Secondary accession number(s): Q2TB29, Q6ZWK3, Q86YW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: January 16, 2019
This is version 112 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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