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Protein

Guanylate kinase

Gene

gmk

Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:cbdbA42
OrganismiDehalococcoides mccartyi (strain CBDB1)
Taxonomic identifieri255470 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002663151 – 206Guanylate kinaseAdd BLAST206

Structurei

3D structure databases

ProteinModelPortaliQ3ZWD8.
SMRiQ3ZWD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 193Guanylate kinase-likeUniRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
KOiK00942.
OMAiAGNYYGT.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ZWD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTNWNFNKT EKPLLLIVSG PSGVGKDAVL ARMKERKLPL TYIVTTTTRP
60 70 80 90 100
KRETETEGVD YNFIRPAEFQ ELISQNELLE WANVYGNFYG VPKAPIRQAL
110 120 130 140 150
SRGSDVIVKV DVQGAASIKK IVPNAVFIFL MPPDMDELTR RLEHRLTESP
160 170 180 190 200
ESLRRRLATA PLEIEKLPDF DYVVVNPEGE IDNAVREIMS IIAAEHCRIQ

PRLIEL
Length:206
Mass (Da):23,431
Last modified:September 27, 2005 - v1
Checksum:iEE24834B8C1E8DE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ965256 Genomic DNA. Translation: CAI82313.1.

Genome annotation databases

EnsemblBacteriaiCAI82313; CAI82313; cbdbA42.
KEGGideh:cbdbA42.

Similar proteinsi

Entry informationi

Entry nameiKGUA_DEHMC
AccessioniPrimary (citable) accession number: Q3ZWD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 27, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program