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Entry version 93 (02 Jun 2021)
Sequence version 1 (27 Sep 2005)
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Protein

Anion exchange protein

Gene

slc4a4a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transportUniRule annotationARBA annotation, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.31.2.9, the anion exchanger (ae) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anion exchange proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:slc4a4aImported
Synonyms:nbce1Imported, slc4a4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060526-274, slc4a4a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei474 – 496HelicalUniRule annotationAdd BLAST23
Transmembranei508 – 537HelicalUniRule annotationAdd BLAST30
Transmembranei557 – 575HelicalUniRule annotationAdd BLAST19
Transmembranei733 – 751HelicalUniRule annotationAdd BLAST19
Transmembranei781 – 800HelicalUniRule annotationAdd BLAST20
Transmembranei821 – 845HelicalUniRule annotationAdd BLAST25
Transmembranei881 – 900HelicalUniRule annotationAdd BLAST20
Transmembranei907 – 926HelicalUniRule annotationAdd BLAST20
Transmembranei958 – 989HelicalUniRule annotationAdd BLAST32

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini142 – 391Band_3_cytoInterPro annotationAdd BLAST250
Domaini440 – 959HCO3_cotranspInterPro annotationAdd BLAST520

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 86DisorderedSequence analysisAdd BLAST41
Regioni239 – 268DisorderedSequence analysisAdd BLAST30
Regioni394 – 434DisorderedSequence analysisAdd BLAST41
Regioni1015 – 1082DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi59 – 77Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi239 – 264Polar residuesSequence analysisAdd BLAST26
Compositional biasi410 – 424Polar residuesSequence analysisAdd BLAST15
Compositional biasi1015 – 1034Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1061 – 1075Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
WSAFYCL

Database of Orthologous Groups

More...
OrthoDBi
265068at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr

The PANTHER Classification System

More...
PANTHERi
PTHR11453, PTHR11453, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804, SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00834, ae, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3ZMH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAGKRVEDE AVLDRGASLL KPLCDQEEVE GHHTIYIGVH VPKSYRRRRR
60 70 80 90 100
RRRRTSHKDR KEKVSENTSD RSDAENNEEA SNSILKPLIS PAAERIRFIL
110 120 130 140 150
GEDDDSPAPP QLFTELDELL SVDGQEMEWK ETARWIKFEE KVEKGGERWS
160 170 180 190 200
KPHVATLSLH SLFELRTCIE KGTIMLDLEA STLPGVVEMI TDSQIESGLL
210 220 230 240 250
KADLKEKVMY TLLRKHRHQT KKSNLRSLAD IGKTVSSASR LFSTPDNGSP
260 270 280 290 300
TTAHRNLTSS SLNDISDKPE KDQLKNKFMK KLPRDAEASN VLVGEVDFLD
310 320 330 340 350
SPFVAFVRLQ QAVMLGALTE VPVPTRFLFI LLGPKGKAKS YHEIGRAIAT
360 370 380 390 400
LMSDEVFHEI AYKAKDRQDL LAGIDEFLDE VIVLPPGEWD PAIRIEPPKS
410 420 430 440 450
LPSSDKRKNM YAGGDSTQMN GDTPHSGGHG GGGHAVGDEL KKTGKFCGGL
460 470 480 490 500
ILDVKRKVPF FFSDFYDSLH IQSLSAILFI YLGTVTNAIT FGGLLGDATE
510 520 530 540 550
NMQGVPESFL GTVVTGAVFC LLAGQPLIIL SSTGPVLVFE RLLFNFSREN
560 570 580 590 600
DFDYLEFRLW IGLWSAFFCL VLVATDASFL VQYFTRFTEE GFSSLISFIF
610 620 630 640 650
IYDAFKKMLK LAHYYPINSD FKIDYVTQYD CMCMAPTDAN SSDVYTDPLD
660 670 680 690 700
STFVWTVNYT TDPRMNATWS SLSKKECLKY GGELVGKACE FVPDITLMSF
710 720 730 740 750
ILFFGTYTCS MCLKKFKTSP FFLTTVRKLI SDFAIILAIL IFCGVDALVG
760 770 780 790 800
VETPKLIVPS EFKPTSPNRG WFVPPFGGNP WWVYLAASVP ALLVTILLFM
810 820 830 840 850
DQQITAVIVN RKEHKLKKGA GYHLDLFWVA VLLAVCSFMG LPWYVAATVI
860 870 880 890 900
SIAHIDSLKM ETETSAPGEQ PKFLGVREQR VTGVMVFILT GISVFMSPVL
910 920 930 940 950
KFIPMPVLYG VFLYMGVASL NGVQFMDRLK LLLMPAKHQP DLIYLRHVPL
960 970 980 990 1000
RKVHLFTFVQ LLCLALLWVL KSTVAAIIFP VMILALVAVR KALDYIFSQH
1010 1020 1030 1040 1050
DLSFLDDVIP EKDKKKKEDE KKKKKKKQGS IDSDMEDSDY PYNENVPSIK
1060 1070 1080
IPMDMMEQEP FLGDKASDRE KSASILDRYS SC
Length:1,082
Mass (Da):121,501
Last modified:September 27, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04446CDAC7E937B1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY727858 mRNA Translation: AAW55810.1

NCBI Reference Sequences

More...
RefSeqi
NP_001030156.1, NM_001034984.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
568631

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:568631

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY727858 mRNA Translation: AAW55810.1
RefSeqiNP_001030156.1, NM_001034984.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi2.A.31.2.9, the anion exchanger (ae) family

Genome annotation databases

GeneIDi568631
KEGGidre:568631

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
568631
ZFINiZDB-GENE-060526-274, slc4a4a

Phylogenomic databases

OMAiWSAFYCL
OrthoDBi265068at2759

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr
PANTHERiPTHR11453, PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit
PRINTSiPR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT
SUPFAMiSSF55804, SSF55804, 1 hit
TIGRFAMsiTIGR00834, ae, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3ZMH2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3ZMH2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 27, 2005
Last sequence update: September 27, 2005
Last modified: June 2, 2021
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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