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UniProtKB - Q3ZCX4 (ZN568_HUMAN)

Entry version 143 (25 May 2022)
Sequence version 2 (02 Oct 2007)
Previous versions | rss
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Protein

Zinc finger protein 568

Gene

ZNF568

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q3ZCX4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q3ZCX4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 568
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF568
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25392, ZNF568

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617566, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q3ZCX4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198453

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		374900

Open Targets

More...OpenTargetsi		ENSG00000198453

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134893477

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q3ZCX4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF568

Domain mapping of disease mutations (DMDM)

More...DMDMi		158706494

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068771 – 644Zinc finger protein 568Add BLAST644

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q3ZCX4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q3ZCX4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q3ZCX4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3ZCX4

PeptideAtlas

More...PeptideAtlasi		Q3ZCX4

PRoteomics IDEntifications database

More...PRIDEi		Q3ZCX4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17705
61920 [Q3ZCX4-1]
61921 [Q3ZCX4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3ZCX4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3ZCX4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198453, Expressed in sural nerve and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q3ZCX4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3ZCX4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198453, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRIM28.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131935, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q3ZCX4, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000481819

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3ZCX4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q3ZCX4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q3ZCX4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 119KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162857

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_57_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3ZCX4

Identification of Orthologs from Complete Genome Data

More...OMAi		HCSSHVV

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3ZCX4

TreeFam database of animal gene trees

More...TreeFami		TF337898

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3ZCX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSQSSVISN SCVTMERLSH MMERKAWCSQ ESALSEEEED TTRPLETVTF 
        60         70         80         90        100
KDVAVDLTQE EWEQMKPAQR NLYRDVMLEN YSNLVTVGCQ VTKPDVIFKL 
       110        120        130        140        150
EQEEEPWVME EEMFGRHCPE VWEVDEQIKK QQETLVRKVT SISKKILIKE 
       160        170        180        190        200
KVIECKKVAK IFPLSSDIVT SRQSFYDCDS LDKGLEHNLD LLRYEKGCVR 
       210        220        230        240        250
EKQSNEFGKP FYHCASYVVT PFKCNQCGQD FSHKFDLIRH ERIHAGEKPY 
       260        270        280        290        300
ECKECGKAFS RKENLITHQK IHTGEKPYKC NECGKAFIQM SNLIRHHRIH 
       310        320        330        340        350
TGEKPYACKD CWKAFSQKSN LIEHERIHTG EKPYECKECG KSFSQKQNLI 
       360        370        380        390        400
EHEKIHTGEK PYACNECGRA FSRMSSVTLH MRSHTGEKPY KCNKCGKAFS 
       410        420        430        440        450
QCSVFIIHMR SHTGEKPYVC SECGKAFSQS SSLTVHMRNH TAEKPYECKE 
       460        470        480        490        500
CGKAFSRKEN LITHQKIHTG EKPYECSECG KAFIQMSNLI RHQRIHTGEK 
       510        520        530        540        550
PYACTVCGKA FSQKSNLTEH EKIHTGEKPY HCNQCGKAFS QRQNLLEHEK 
       560        570        580        590        600
IHTGEKPFKC NECGKAFSRI SSLTLHVRSH TGEKPYECNK CGKAFSQCSL 
       610        620        630        640 
LIIHMRSHTG EKPFECNECG KAFSQRASLS IHKRGHTGER HQVY
Length:644
Mass (Da):74,369
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEEED67D5D8E7DA2
GO
Isoform 2 (identifier: Q3ZCX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Show »
Length:580
Mass (Da):67,001
Checksum:iC5CD80B13EADEEA1
GO
Isoform 3 (identifier: Q3ZCX4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.
     121-644: VWEVDEQIKK...GHTGERHQVY → PRRGENCCAS...KPFGGGSELS

Show »
Length:571
Mass (Da):66,602
Checksum:i38235E0D518C54A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZ84A0A087WZ84_HUMAN
Zinc finger protein 568
ZNF568
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLX5C9JLX5_HUMAN
Zinc finger protein 568
ZNF568
583Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0F2C9K0F2_HUMAN
Zinc finger protein 568
ZNF568
382Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGP9A0A0C4DGP9_HUMAN
Zinc finger protein 568
ZNF568
530Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ58C9JZ58_HUMAN
Zinc finger protein 568
ZNF568
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL97K7EL97_HUMAN
Zinc finger protein 568
ZNF568
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JXQ5C9JXQ5_HUMAN
Zinc finger protein 568
ZNF568
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKY2K7EKY2_HUMAN
Zinc finger protein 568
ZNF568
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELK8K7ELK8_HUMAN
Zinc finger protein 568
ZNF568
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y8EHF7A0A1Y8EHF7_HUMAN
Zinc finger protein 568
ZNF568
7Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH31218 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH31218 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAE45810 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96V → M in AAH31218 (PubMed:15489334).Curated1
Sequence conflicti128I → V in CAE45810 (PubMed:17974005).Curated1
Isoform 3 (identifier: Q3ZCX4-3)
Sequence conflicti542L → P in BAG61554 (PubMed:14702039).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Isoform 3 is highly polymorphic with three major alleles: H, C1 and C1. The H allele is found at higher frequencies in Japanese (0.71) and Taiwan Chinese (0.72) populations compared to European (0.45) and African (0.39) populations. The H allele may be associated with smaller head size in infants.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052867437M → T. Corresponds to variant dbSNP:rs547483Ensembl.1
Natural variantiVAR_052868642Q → R. Corresponds to variant dbSNP:rs1644634Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0285561 – 64Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST64
Alternative sequenceiVSP_046815121 – 644VWEVD…RHQVY → PRRGENCCASEVMAEGLKFK DVVIYFSQKEWECLHSAQKD LYRDVMLENYGNLVLLGLSD TKPNVISLLEQKKEPWMVKR KETKEWCPDWEFGRETKNLS PKENIYEIRSPQQEKARVIR EIRCQVERQQGHQEGHFRPA VIPFTSMQCTAHREYQWLHT GEKSCECRKCKNAFRYQSCP IQHEIIHNKEKEPECGECRK IFNSGSDLIKHQTLHESKKH SENNKCAFNHDSGITQPQSI NTGEKPHKCKECGKAFRSSS QISQHQRMHLGEKPYKCREC GKAFPSTAQLNLHQRIHTDE KYYESKACGKAFTRPSHLFR HQRIHTGEKPHKCKECGKAF RYDTQLSLHQIIHTGERRYE CRECGKVYSCASQLSLHQRI HTGEKPHECKECGKAFISDS HLIRHQSVHTGEKPCKCKEC GKSFRRGSELTRHQRAHTGE KPYECKECEKAFTCSTELVR HQKVHTGERPHKCKECGKAF IRRSELTHHERSHTGEKPYE CKECGKPFGGGSELS in isoform 3. 1 PublicationAdd BLAST524

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK093123 mRNA Translation: BAC04064.1
AK299626 mRNA Translation: BAG61554.1
BX640681 mRNA Translation: CAE45810.1 Frameshift.
AC008733 Genomic DNA No translation available.
BC031218 mRNA Translation: AAH31218.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42558.1 [Q3ZCX4-1]
CCDS56092.1 [Q3ZCX4-2]
CCDS56093.1 [Q3ZCX4-3]

NCBI Reference Sequences

More...RefSeqi		NP_001191764.1, NM_001204835.1
NP_001191765.1, NM_001204836.1 [Q3ZCX4-2]
NP_001191766.1, NM_001204837.1 [Q3ZCX4-2]
NP_001191767.1, NM_001204838.1
NP_001191768.1, NM_001204839.1 [Q3ZCX4-3]
NP_940941.2, NM_198539.3 [Q3ZCX4-1]
XP_016882262.1, XM_017026773.1 [Q3ZCX4-2]
XP_016882263.1, XM_017026774.1 [Q3ZCX4-2]
XP_016882264.1, XM_017026775.1 [Q3ZCX4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000333987.12; ENSP00000334685.7; ENSG00000198453.14
ENST00000415168.5; ENSP00000394514.1; ENSG00000198453.14 [Q3ZCX4-2]
ENST00000455427.6; ENSP00000413396.2; ENSG00000198453.14 [Q3ZCX4-3]
ENST00000619231.4; ENSP00000481819.1; ENSG00000198453.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		374900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:374900

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000333987.12; ENSP00000334685.7; NM_198539.4; NP_940941.2

UCSC genome browser

More...UCSCi		uc002ofc.4, human [Q3ZCX4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093123 mRNA Translation: BAC04064.1
AK299626 mRNA Translation: BAG61554.1
BX640681 mRNA Translation: CAE45810.1 Frameshift.
AC008733 Genomic DNA No translation available.
BC031218 mRNA Translation: AAH31218.1 Sequence problems.
CCDSiCCDS42558.1 [Q3ZCX4-1]
CCDS56092.1 [Q3ZCX4-2]
CCDS56093.1 [Q3ZCX4-3]
RefSeqiNP_001191764.1, NM_001204835.1
NP_001191765.1, NM_001204836.1 [Q3ZCX4-2]
NP_001191766.1, NM_001204837.1 [Q3ZCX4-2]
NP_001191767.1, NM_001204838.1
NP_001191768.1, NM_001204839.1 [Q3ZCX4-3]
NP_940941.2, NM_198539.3 [Q3ZCX4-1]
XP_016882262.1, XM_017026773.1 [Q3ZCX4-2]
XP_016882263.1, XM_017026774.1 [Q3ZCX4-2]
XP_016882264.1, XM_017026775.1 [Q3ZCX4-3]

3D structure databases

AlphaFoldDBiQ3ZCX4
SMRiQ3ZCX4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131935, 7 interactors
IntActiQ3ZCX4, 1 interactor
STRINGi9606.ENSP00000481819

PTM databases

iPTMnetiQ3ZCX4
PhosphoSitePlusiQ3ZCX4

Genetic variation databases

BioMutaiZNF568
DMDMi158706494

Proteomic databases

jPOSTiQ3ZCX4
MassIVEiQ3ZCX4
MaxQBiQ3ZCX4
PaxDbiQ3ZCX4
PeptideAtlasiQ3ZCX4
PRIDEiQ3ZCX4
ProteomicsDBi17705
61920 [Q3ZCX4-1]
61921 [Q3ZCX4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29844, 123 antibodies from 15 providers

The DNASU plasmid repository

More...DNASUi		374900

Genome annotation databases

EnsembliENST00000333987.12; ENSP00000334685.7; ENSG00000198453.14
ENST00000415168.5; ENSP00000394514.1; ENSG00000198453.14 [Q3ZCX4-2]
ENST00000455427.6; ENSP00000413396.2; ENSG00000198453.14 [Q3ZCX4-3]
ENST00000619231.4; ENSP00000481819.1; ENSG00000198453.14
GeneIDi374900
KEGGihsa:374900
MANE-SelectiENST00000333987.12; ENSP00000334685.7; NM_198539.4; NP_940941.2
UCSCiuc002ofc.4, human [Q3ZCX4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		374900
DisGeNETi374900

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF568
HGNCiHGNC:25392, ZNF568
HPAiENSG00000198453, Low tissue specificity
MIMi617566, gene
neXtProtiNX_Q3ZCX4
OpenTargetsiENSG00000198453
PharmGKBiPA134893477
VEuPathDBiHostDB:ENSG00000198453

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162857
HOGENOMiCLU_002678_57_1_1
InParanoidiQ3ZCX4
OMAiHCSSHVV
PhylomeDBiQ3ZCX4
TreeFamiTF337898

Enzyme and pathway databases

PathwayCommonsiQ3ZCX4
ReactomeiR-HSA-212436, Generic Transcription Pathway
SignaLinkiQ3ZCX4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		374900, 12 hits in 1095 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF568, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		374900
PharosiQ3ZCX4, Tdark

Protein Ontology

More...PROi		PR:Q3ZCX4
RNActiQ3ZCX4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198453, Expressed in sural nerve and 179 other tissues
ExpressionAtlasiQ3ZCX4, baseline and differential
GenevisibleiQ3ZCX4, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 15 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN568_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3ZCX4
Secondary accession number(s): B4DS92
, E7ER33, Q6N060, Q8NA64
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 25, 2022
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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