UniProtKB - Q3ZCX4 (ZN568_HUMAN)
Protein
Zinc finger protein 568
Gene
ZNF568
Organism
Homo sapiens (Human)
Status
Functioni
Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 244 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 306 – 328 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 334 – 356 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 362 – 384 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 390 – 412 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 446 – 468 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 474 – 496 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 502 – 524 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 530 – 552 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 558 – 580 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 586 – 608 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 614 – 636 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- embryonic placenta morphogenesis Source: UniProtKB
- in utero embryonic development Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q3ZCX4 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 568 |
Gene namesi | Name:ZNF568 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25392, ZNF568 |
MIMi | 617566, gene |
neXtProti | NX_Q3ZCX4 |
VEuPathDBi | HostDB:ENSG00000198453.12 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 374900 |
OpenTargetsi | ENSG00000198453 |
PharmGKBi | PA134893477 |
Miscellaneous databases
Pharosi | Q3ZCX4, Tdark |
Genetic variation databases
BioMutai | ZNF568 |
DMDMi | 158706494 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000306877 | 1 – 644 | Zinc finger protein 568Add BLAST | 644 |
Proteomic databases
jPOSTi | Q3ZCX4 |
MassIVEi | Q3ZCX4 |
MaxQBi | Q3ZCX4 |
PaxDbi | Q3ZCX4 |
PeptideAtlasi | Q3ZCX4 |
PRIDEi | Q3ZCX4 |
ProteomicsDBi | 17705 61920 [Q3ZCX4-1] 61921 [Q3ZCX4-2] |
PTM databases
iPTMneti | Q3ZCX4 |
PhosphoSitePlusi | Q3ZCX4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198453, Expressed in sural nerve and 179 other tissues |
ExpressionAtlasi | Q3ZCX4, baseline and differential |
Genevisiblei | Q3ZCX4, HS |
Organism-specific databases
HPAi | ENSG00000198453, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with TRIM28.
By similarityProtein-protein interaction databases
BioGRIDi | 131935, 4 interactors |
IntActi | Q3ZCX4, 1 interactor |
STRINGi | 9606.ENSP00000481819 |
Miscellaneous databases
RNActi | Q3ZCX4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 119 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 244 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 306 – 328 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 334 – 356 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 362 – 384 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 390 – 412 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 446 – 468 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 474 – 496 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 502 – 524 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 530 – 552 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 558 – 580 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 586 – 608 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 614 – 636 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162857 |
HOGENOMi | CLU_002678_57_1_1 |
InParanoidi | Q3ZCX4 |
OMAi | KPFYHCA |
PhylomeDBi | Q3ZCX4 |
TreeFami | TF337898 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 15 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q3ZCX4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTSQSSVISN SCVTMERLSH MMERKAWCSQ ESALSEEEED TTRPLETVTF
60 70 80 90 100
KDVAVDLTQE EWEQMKPAQR NLYRDVMLEN YSNLVTVGCQ VTKPDVIFKL
110 120 130 140 150
EQEEEPWVME EEMFGRHCPE VWEVDEQIKK QQETLVRKVT SISKKILIKE
160 170 180 190 200
KVIECKKVAK IFPLSSDIVT SRQSFYDCDS LDKGLEHNLD LLRYEKGCVR
210 220 230 240 250
EKQSNEFGKP FYHCASYVVT PFKCNQCGQD FSHKFDLIRH ERIHAGEKPY
260 270 280 290 300
ECKECGKAFS RKENLITHQK IHTGEKPYKC NECGKAFIQM SNLIRHHRIH
310 320 330 340 350
TGEKPYACKD CWKAFSQKSN LIEHERIHTG EKPYECKECG KSFSQKQNLI
360 370 380 390 400
EHEKIHTGEK PYACNECGRA FSRMSSVTLH MRSHTGEKPY KCNKCGKAFS
410 420 430 440 450
QCSVFIIHMR SHTGEKPYVC SECGKAFSQS SSLTVHMRNH TAEKPYECKE
460 470 480 490 500
CGKAFSRKEN LITHQKIHTG EKPYECSECG KAFIQMSNLI RHQRIHTGEK
510 520 530 540 550
PYACTVCGKA FSQKSNLTEH EKIHTGEKPY HCNQCGKAFS QRQNLLEHEK
560 570 580 590 600
IHTGEKPFKC NECGKAFSRI SSLTLHVRSH TGEKPYECNK CGKAFSQCSL
610 620 630 640
LIIHMRSHTG EKPFECNECG KAFSQRASLS IHKRGHTGER HQVY
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZ84 | A0A087WZ84_HUMAN | Zinc finger protein 568 | ZNF568 | 635 | Annotation score: | ||
C9K0F2 | C9K0F2_HUMAN | Zinc finger protein 568 | ZNF568 | 382 | Annotation score: | ||
C9JLX5 | C9JLX5_HUMAN | Zinc finger protein 568 | ZNF568 | 583 | Annotation score: | ||
A0A087WWI3 | A0A087WWI3_HUMAN | Zinc finger protein 568 | ZNF568 | 377 | Annotation score: | ||
A0A0C4DGP9 | A0A0C4DGP9_HUMAN | Zinc finger protein 568 | ZNF568 | 530 | Annotation score: | ||
C9JZ58 | C9JZ58_HUMAN | Zinc finger protein 568 | ZNF568 | 171 | Annotation score: | ||
K7EL97 | K7EL97_HUMAN | Zinc finger protein 568 | ZNF568 | 25 | Annotation score: | ||
C9JXQ5 | C9JXQ5_HUMAN | Zinc finger protein 568 | ZNF568 | 79 | Annotation score: | ||
K7EKY2 | K7EKY2_HUMAN | Zinc finger protein 568 | ZNF568 | 39 | Annotation score: | ||
K7ELK8 | K7ELK8_HUMAN | Zinc finger protein 568 | ZNF568 | 58 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
The sequence AAH31218 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH31218 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAE45810 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 96 | V → M in AAH31218 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 128 | I → V in CAE45810 (PubMed:17974005).Curated | 1 | ||
Isoform 3 (identifier: Q3ZCX4-3) | |||||
Sequence conflicti | 542 | L → P in BAG61554 (PubMed:14702039).Curated | 1 |
Polymorphismi
Isoform 3 is highly polymorphic with three major alleles: H, C1 and C1. The H allele is found at higher frequencies in Japanese (0.71) and Taiwan Chinese (0.72) populations compared to European (0.45) and African (0.39) populations. The H allele may be associated with smaller head size in infants.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052867 | 437 | M → T. Corresponds to variant dbSNP:rs547483Ensembl. | 1 | |
Natural variantiVAR_052868 | 642 | Q → R. Corresponds to variant dbSNP:rs1644634Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028556 | 1 – 64 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 64 | |
Alternative sequenceiVSP_046815 | 121 – 644 | VWEVD…RHQVY → PRRGENCCASEVMAEGLKFK DVVIYFSQKEWECLHSAQKD LYRDVMLENYGNLVLLGLSD TKPNVISLLEQKKEPWMVKR KETKEWCPDWEFGRETKNLS PKENIYEIRSPQQEKARVIR EIRCQVERQQGHQEGHFRPA VIPFTSMQCTAHREYQWLHT GEKSCECRKCKNAFRYQSCP IQHEIIHNKEKEPECGECRK IFNSGSDLIKHQTLHESKKH SENNKCAFNHDSGITQPQSI NTGEKPHKCKECGKAFRSSS QISQHQRMHLGEKPYKCREC GKAFPSTAQLNLHQRIHTDE KYYESKACGKAFTRPSHLFR HQRIHTGEKPHKCKECGKAF RYDTQLSLHQIIHTGERRYE CRECGKVYSCASQLSLHQRI HTGEKPHECKECGKAFISDS HLIRHQSVHTGEKPCKCKEC GKSFRRGSELTRHQRAHTGE KPYECKECEKAFTCSTELVR HQKVHTGERPHKCKECGKAF IRRSELTHHERSHTGEKPYE CKECGKPFGGGSELS in isoform 3. 1 PublicationAdd BLAST | 524 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093123 mRNA Translation: BAC04064.1 AK299626 mRNA Translation: BAG61554.1 BX640681 mRNA Translation: CAE45810.1 Frameshift. AC008733 Genomic DNA No translation available. BC031218 mRNA Translation: AAH31218.1 Sequence problems. |
CCDSi | CCDS42558.1 [Q3ZCX4-1] CCDS56092.1 [Q3ZCX4-2] CCDS56093.1 [Q3ZCX4-3] |
RefSeqi | NP_001191764.1, NM_001204835.1 NP_001191765.1, NM_001204836.1 [Q3ZCX4-2] NP_001191766.1, NM_001204837.1 [Q3ZCX4-2] NP_001191767.1, NM_001204838.1 NP_001191768.1, NM_001204839.1 [Q3ZCX4-3] NP_940941.2, NM_198539.3 [Q3ZCX4-1] XP_016882262.1, XM_017026773.1 [Q3ZCX4-2] XP_016882263.1, XM_017026774.1 [Q3ZCX4-2] XP_016882264.1, XM_017026775.1 [Q3ZCX4-3] |
Genome annotation databases
Ensembli | ENST00000333987; ENSP00000334685; ENSG00000198453 [Q3ZCX4-1] ENST00000415168; ENSP00000394514; ENSG00000198453 [Q3ZCX4-2] ENST00000455427; ENSP00000413396; ENSG00000198453 [Q3ZCX4-3] ENST00000619231; ENSP00000481819; ENSG00000198453 [Q3ZCX4-1] |
GeneIDi | 374900 |
KEGGi | hsa:374900 |
UCSCi | uc002ofc.4, human [Q3ZCX4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093123 mRNA Translation: BAC04064.1 AK299626 mRNA Translation: BAG61554.1 BX640681 mRNA Translation: CAE45810.1 Frameshift. AC008733 Genomic DNA No translation available. BC031218 mRNA Translation: AAH31218.1 Sequence problems. |
CCDSi | CCDS42558.1 [Q3ZCX4-1] CCDS56092.1 [Q3ZCX4-2] CCDS56093.1 [Q3ZCX4-3] |
RefSeqi | NP_001191764.1, NM_001204835.1 NP_001191765.1, NM_001204836.1 [Q3ZCX4-2] NP_001191766.1, NM_001204837.1 [Q3ZCX4-2] NP_001191767.1, NM_001204838.1 NP_001191768.1, NM_001204839.1 [Q3ZCX4-3] NP_940941.2, NM_198539.3 [Q3ZCX4-1] XP_016882262.1, XM_017026773.1 [Q3ZCX4-2] XP_016882263.1, XM_017026774.1 [Q3ZCX4-2] XP_016882264.1, XM_017026775.1 [Q3ZCX4-3] |
3D structure databases
SMRi | Q3ZCX4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131935, 4 interactors |
IntActi | Q3ZCX4, 1 interactor |
STRINGi | 9606.ENSP00000481819 |
PTM databases
iPTMneti | Q3ZCX4 |
PhosphoSitePlusi | Q3ZCX4 |
Genetic variation databases
BioMutai | ZNF568 |
DMDMi | 158706494 |
Proteomic databases
jPOSTi | Q3ZCX4 |
MassIVEi | Q3ZCX4 |
MaxQBi | Q3ZCX4 |
PaxDbi | Q3ZCX4 |
PeptideAtlasi | Q3ZCX4 |
PRIDEi | Q3ZCX4 |
ProteomicsDBi | 17705 61920 [Q3ZCX4-1] 61921 [Q3ZCX4-2] |
Protocols and materials databases
Antibodypediai | 29844, 123 antibodies |
Genome annotation databases
Ensembli | ENST00000333987; ENSP00000334685; ENSG00000198453 [Q3ZCX4-1] ENST00000415168; ENSP00000394514; ENSG00000198453 [Q3ZCX4-2] ENST00000455427; ENSP00000413396; ENSG00000198453 [Q3ZCX4-3] ENST00000619231; ENSP00000481819; ENSG00000198453 [Q3ZCX4-1] |
GeneIDi | 374900 |
KEGGi | hsa:374900 |
UCSCi | uc002ofc.4, human [Q3ZCX4-1] |
Organism-specific databases
CTDi | 374900 |
DisGeNETi | 374900 |
GeneCardsi | ZNF568 |
HGNCi | HGNC:25392, ZNF568 |
HPAi | ENSG00000198453, Low tissue specificity |
MIMi | 617566, gene |
neXtProti | NX_Q3ZCX4 |
OpenTargetsi | ENSG00000198453 |
PharmGKBi | PA134893477 |
VEuPathDBi | HostDB:ENSG00000198453.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162857 |
HOGENOMi | CLU_002678_57_1_1 |
InParanoidi | Q3ZCX4 |
OMAi | KPFYHCA |
PhylomeDBi | Q3ZCX4 |
TreeFami | TF337898 |
Enzyme and pathway databases
PathwayCommonsi | Q3ZCX4 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 374900, 7 hits in 1012 CRISPR screens |
ChiTaRSi | ZNF568, human |
GenomeRNAii | 374900 |
Pharosi | Q3ZCX4, Tdark |
PROi | PR:Q3ZCX4 |
RNActi | Q3ZCX4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198453, Expressed in sural nerve and 179 other tissues |
ExpressionAtlasi | Q3ZCX4, baseline and differential |
Genevisiblei | Q3ZCX4, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 15 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN568_HUMAN | |
Accessioni | Q3ZCX4Primary (citable) accession number: Q3ZCX4 Secondary accession number(s): B4DS92 Q8NA64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families