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Protein

Lymphocyte expansion molecule

Gene

LEXM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Was reported to promote CD8+ T cell immunity through effects on mitochondrial respiration (PubMed:25883318). However, the corresponding article has been retracted (PubMed:27980177).

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte expansion molecule1 Publication
Gene namesi
Name:LEXMImported
Synonyms:LEM1 Publication
ORF Names:C1orf177
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162398.11
HGNCiHGNC:26854 LEXM
MIMi616446 gene
neXtProtiNX_Q3ZCV2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi163747
OpenTargetsiENSG00000162398
PharmGKBiPA142672425

Polymorphism and mutation databases

BioMutaiC1orf177
DMDMi223590240

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002975851 – 418Lymphocyte expansion moleculeAdd BLAST418

Proteomic databases

EPDiQ3ZCV2
PaxDbiQ3ZCV2
PeptideAtlasiQ3ZCV2
PRIDEiQ3ZCV2
ProteomicsDBi61917
61918 [Q3ZCV2-2]

PTM databases

iPTMnetiQ3ZCV2
PhosphoSitePlusiQ3ZCV2

Expressioni

Inductioni

Up-regulated in activated CD8+ T-cells.1 Publication

Gene expression databases

BgeeiENSG00000162398 Expressed in 47 organ(s), highest expression level in esophagus squamous epithelium
CleanExiHS_C1orf177
GenevisibleiQ3ZCV2 HS

Organism-specific databases

HPAiHPA035889
HPA035890

Interactioni

Protein-protein interaction databases

BioGridi127877, 2 interactors
STRINGi9606.ENSP00000360320

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IG0F Eukaryota
ENOG410XYWM LUCA
GeneTreeiENSGT00390000015471
HOGENOMiHOG000007878
HOVERGENiHBG095692
InParanoidiQ3ZCV2
OrthoDBiEOG091G0LV6
PhylomeDBiQ3ZCV2
TreeFamiTF329164

Family and domain databases

InterProiView protein in InterPro
IPR033557 LEXM
PANTHERiPTHR34914 PTHR34914, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3ZCV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRESQDAAGA HGWNRVGSTA TKWFTGAPFG VQSHRFDISA VYPNWKKFST
60 70 80 90 100
FTEAPYSTRY STQVSHIGPG TYSSKETCFS KKKLMKEVDT GWAKAQEATR
110 120 130 140 150
LTQLPHFQYQ AIMKEKRLKE QKLGPGSYNL KDFLEQLREK PCSTRGLLSS
160 170 180 190 200
GEVRFRGLTG NYYPGPGNYG EKGNPYTKLE ENAWNRSHSE GLMCRMSNKP
210 220 230 240 250
HPRPHQGSGL GPGTYFFKSD LETYVARSVG TRGPYDTFSG DRSKPLPYGH
260 270 280 290 300
YSMQKKKPRE LMNFKSFVEE LNSHHNKKHG VFSKLPRNPK TPTERIYWAN
310 320 330 340 350
LSQCPRTLAT SGPSFWLPQE KKCKPVNQPP FLLTSKGSGA KACQMIMGSW
360 370 380 390 400
NPVGVGRYLN TWLMETKDRR QRYRSLFLSG SKRYLSDLAR DMLMQERITP
410
FTKGKCPPTV DYNSDPTP
Length:418
Mass (Da):47,583
Last modified:March 28, 2018 - v4
Checksum:iA7B9DFB970B73C2C
GO
Isoform 2 (identifier: Q3ZCV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     396-418: ERITPFTKGKCPPTVDYNSDPTP → IRLFCWKGLEVINFGLSPM

Show »
Length:414
Mass (Da):47,243
Checksum:i09DE149F70BAA467
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122K → R in AAH39109 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034645126G → C2 PublicationsCorresponds to variant dbSNP:rs9782980Ensembl.1
Natural variantiVAR_054410205H → Y. Corresponds to variant dbSNP:rs600499Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027294396 – 418ERITP…SDPTP → IRLFCWKGLEVINFGLSPM in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097520 mRNA Translation: BAC05087.1
AC096536 Genomic DNA No translation available.
KF495955 Genomic DNA No translation available.
BC039109 mRNA Translation: AAH39109.1
BC064142 mRNA Translation: AAH64142.1
CCDSiCCDS44153.1 [Q3ZCV2-1]
CCDS599.1 [Q3ZCV2-2]
RefSeqiNP_001104003.1, NM_001110533.1 [Q3ZCV2-1]
NP_689820.2, NM_152607.2 [Q3ZCV2-2]
UniGeneiHs.376018

Genome annotation databases

EnsembliENST00000358193; ENSP00000350924; ENSG00000162398 [Q3ZCV2-2]
ENST00000371273; ENSP00000360320; ENSG00000162398 [Q3ZCV2-1]
GeneIDi163747
KEGGihsa:163747
UCSCiuc001cya.5 human [Q3ZCV2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097520 mRNA Translation: BAC05087.1
AC096536 Genomic DNA No translation available.
KF495955 Genomic DNA No translation available.
BC039109 mRNA Translation: AAH39109.1
BC064142 mRNA Translation: AAH64142.1
CCDSiCCDS44153.1 [Q3ZCV2-1]
CCDS599.1 [Q3ZCV2-2]
RefSeqiNP_001104003.1, NM_001110533.1 [Q3ZCV2-1]
NP_689820.2, NM_152607.2 [Q3ZCV2-2]
UniGeneiHs.376018

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127877, 2 interactors
STRINGi9606.ENSP00000360320

PTM databases

iPTMnetiQ3ZCV2
PhosphoSitePlusiQ3ZCV2

Polymorphism and mutation databases

BioMutaiC1orf177
DMDMi223590240

Proteomic databases

EPDiQ3ZCV2
PaxDbiQ3ZCV2
PeptideAtlasiQ3ZCV2
PRIDEiQ3ZCV2
ProteomicsDBi61917
61918 [Q3ZCV2-2]

Protocols and materials databases

DNASUi163747
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358193; ENSP00000350924; ENSG00000162398 [Q3ZCV2-2]
ENST00000371273; ENSP00000360320; ENSG00000162398 [Q3ZCV2-1]
GeneIDi163747
KEGGihsa:163747
UCSCiuc001cya.5 human [Q3ZCV2-1]

Organism-specific databases

CTDi163747
DisGeNETi163747
EuPathDBiHostDB:ENSG00000162398.11
GeneCardsiLEXM
HGNCiHGNC:26854 LEXM
HPAiHPA035889
HPA035890
MIMi616446 gene
neXtProtiNX_Q3ZCV2
OpenTargetsiENSG00000162398
PharmGKBiPA142672425
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG0F Eukaryota
ENOG410XYWM LUCA
GeneTreeiENSGT00390000015471
HOGENOMiHOG000007878
HOVERGENiHBG095692
InParanoidiQ3ZCV2
OrthoDBiEOG091G0LV6
PhylomeDBiQ3ZCV2
TreeFamiTF329164

Miscellaneous databases

ChiTaRSiLEXM human
GenomeRNAii163747
PROiPR:Q3ZCV2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162398 Expressed in 47 organ(s), highest expression level in esophagus squamous epithelium
CleanExiHS_C1orf177
GenevisibleiQ3ZCV2 HS

Family and domain databases

InterProiView protein in InterPro
IPR033557 LEXM
PANTHERiPTHR34914 PTHR34914, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLEXM_HUMAN
AccessioniPrimary (citable) accession number: Q3ZCV2
Secondary accession number(s): B7WPL2, Q8N7Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 28, 2018
Last modified: September 12, 2018
This is version 96 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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