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UniProtKB - Q3ZCT1 (ZN260_HUMAN)
Protein
Zinc finger protein 260
Gene
ZNF260
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).
By similarityCaution
It is uncertain whether Met-1 or Met-4 is the initiator.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 27 – 49 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 55 – 77 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 83 – 105 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 136 – 158 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 164 – 186 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 192 – 214 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 220 – 242 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 248 – 270 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 276 – 298 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 304 – 326 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 332 – 354 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 360 – 382 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 388 – 412 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q3ZCT1 |
SignaLinki | Q3ZCT1 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 260Short name: Zfp-260 |
Gene namesi | Name:ZNF260 Synonyms:ZFP260 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13499, ZNF260 |
MIMi | 613749, gene |
neXtProti | NX_Q3ZCT1 |
VEuPathDBi | HostDB:ENSG00000254004 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 339324 |
OpenTargetsi | ENSG00000254004 |
PharmGKBi | PA145147548 |
Miscellaneous databases
Pharosi | Q3ZCT1, Tdark |
Genetic variation databases
BioMutai | ZNF260 |
DMDMi | 215274187 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047320 | 1 – 412 | Zinc finger protein 260Add BLAST | 412 |
Proteomic databases
EPDi | Q3ZCT1 |
jPOSTi | Q3ZCT1 |
MassIVEi | Q3ZCT1 |
PaxDbi | Q3ZCT1 |
PeptideAtlasi | Q3ZCT1 |
PRIDEi | Q3ZCT1 |
ProteomicsDBi | 61911 |
PTM databases
iPTMneti | Q3ZCT1 |
PhosphoSitePlusi | Q3ZCT1 |
Expressioni
Inductioni
Up-regulated by activation of alpha1-adrenergic receptors.1 Publication
Gene expression databases
Bgeei | ENSG00000254004, Expressed in testis and 221 other tissues |
Genevisiblei | Q3ZCT1, HS |
Organism-specific databases
HPAi | ENSG00000254004, Low tissue specificity |
Interactioni
Subunit structurei
Binds DNA.
Interacts with GATA4 (By similarity).
By similarityBinary interactionsi
Q3ZCT1
With | #Exp. | IntAct |
---|---|---|
KRTAP10-7 [P60409] | 3 | EBI-10241410,EBI-10172290 |
NDEL1 [Q9GZM8] | 3 | EBI-10241410,EBI-928842 |
ZNF648 [Q5T619] | 3 | EBI-10241410,EBI-11985915 |
Protein-protein interaction databases
BioGRIDi | 130868, 8 interactors |
IntActi | Q3ZCT1, 4 interactors |
STRINGi | 9606.ENSP00000429803 |
Miscellaneous databases
RNActi | Q3ZCT1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 27 – 49 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 55 – 77 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 83 – 105 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 136 – 158 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 164 – 186 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 192 – 214 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 220 – 242 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 248 – 270 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 276 – 298 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 304 – 326 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 332 – 354 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 360 – 382 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 388 – 412 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162468 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q3ZCT1 |
OMAi | FSQKSHY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q3ZCT1 |
TreeFami | TF341817 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
i Sequence
Sequence statusi: Complete.
Q3ZCT1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIGMLESLQH ESDLLQHDQI HTGEKPYECN ECRKTFSLKQ NLVEHKKMHT
60 70 80 90 100
GEKSHECTEC GKVCSRVSSL TLHLRSHTGK KAYKCNKCGK AFSQKENFLS
110 120 130 140 150
HQKHHTGEKP YECEKVSIQM PTIIRHQKNH TGTKPYACKE CGKAFNGKAY
160 170 180 190 200
LTEHEKIHTG EKPFECNQCG RAFSQKQYLI KHQNIHTGKK PFKCSECGKA
210 220 230 240 250
FSQKENLIIH QRIHTGEKPY ECKGCGKAFI QKSSLIRHQR SHTGEKPYTC
260 270 280 290 300
KECGKAFSGK SNLTEHEKIH IGEKPYKCNE CGTIFRQKQY LIKHHNIHTG
310 320 330 340 350
EKPYECNKCG KAFSRITSLI VHVRIHTGDK PYECKVCGKA FCQSSSLTVH
360 370 380 390 400
MRSHTGEKPY GCNECGKAFS QFSTLALHMR IHTGEKPYQC SECGKAFSQK
410
SHHIRHQRIH TH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092295 Genomic DNA No translation available. BC042676 mRNA Translation: AAH42676.1 BC119003 mRNA Translation: AAI19004.1 BC122549 mRNA Translation: AAI22550.1 |
CCDSi | CCDS33003.1 |
RefSeqi | NP_001012774.1, NM_001012756.2 NP_001159508.1, NM_001166036.1 NP_001159509.1, NM_001166037.1 NP_001159510.1, NM_001166038.1 XP_011525199.1, XM_011526897.2 XP_016882230.1, XM_017026741.1 |
Genome annotation databases
Ensembli | ENST00000523638; ENSP00000429803; ENSG00000254004 ENST00000588993; ENSP00000467219; ENSG00000254004 ENST00000592282; ENSP00000464964; ENSG00000254004 ENST00000593142; ENSP00000465834; ENSG00000254004 |
GeneIDi | 339324 |
KEGGi | hsa:339324 |
MANE-Selecti | ENST00000523638.6; ENSP00000429803.1; NM_001166037.2; NP_001159509.1 |
UCSCi | uc002oee.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092295 Genomic DNA No translation available. BC042676 mRNA Translation: AAH42676.1 BC119003 mRNA Translation: AAI19004.1 BC122549 mRNA Translation: AAI22550.1 |
CCDSi | CCDS33003.1 |
RefSeqi | NP_001012774.1, NM_001012756.2 NP_001159508.1, NM_001166036.1 NP_001159509.1, NM_001166037.1 NP_001159510.1, NM_001166038.1 XP_011525199.1, XM_011526897.2 XP_016882230.1, XM_017026741.1 |
3D structure databases
SMRi | Q3ZCT1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130868, 8 interactors |
IntActi | Q3ZCT1, 4 interactors |
STRINGi | 9606.ENSP00000429803 |
PTM databases
iPTMneti | Q3ZCT1 |
PhosphoSitePlusi | Q3ZCT1 |
Genetic variation databases
BioMutai | ZNF260 |
DMDMi | 215274187 |
Proteomic databases
EPDi | Q3ZCT1 |
jPOSTi | Q3ZCT1 |
MassIVEi | Q3ZCT1 |
PaxDbi | Q3ZCT1 |
PeptideAtlasi | Q3ZCT1 |
PRIDEi | Q3ZCT1 |
ProteomicsDBi | 61911 |
Protocols and materials databases
Antibodypediai | 48040, 48 antibodies from 11 providers |
DNASUi | 339324 |
Genome annotation databases
Ensembli | ENST00000523638; ENSP00000429803; ENSG00000254004 ENST00000588993; ENSP00000467219; ENSG00000254004 ENST00000592282; ENSP00000464964; ENSG00000254004 ENST00000593142; ENSP00000465834; ENSG00000254004 |
GeneIDi | 339324 |
KEGGi | hsa:339324 |
MANE-Selecti | ENST00000523638.6; ENSP00000429803.1; NM_001166037.2; NP_001159509.1 |
UCSCi | uc002oee.3, human |
Organism-specific databases
CTDi | 339324 |
DisGeNETi | 339324 |
GeneCardsi | ZNF260 |
HGNCi | HGNC:13499, ZNF260 |
HPAi | ENSG00000254004, Low tissue specificity |
MIMi | 613749, gene |
neXtProti | NX_Q3ZCT1 |
OpenTargetsi | ENSG00000254004 |
PharmGKBi | PA145147548 |
VEuPathDBi | HostDB:ENSG00000254004 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162468 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q3ZCT1 |
OMAi | FSQKSHY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q3ZCT1 |
TreeFami | TF341817 |
Enzyme and pathway databases
PathwayCommonsi | Q3ZCT1 |
SignaLinki | Q3ZCT1 |
Miscellaneous databases
BioGRID-ORCSi | 339324, 6 hits in 1045 CRISPR screens |
ChiTaRSi | ZNF260, human |
GenomeRNAii | 339324 |
Pharosi | Q3ZCT1, Tdark |
PROi | PR:Q3ZCT1 |
RNActi | Q3ZCT1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000254004, Expressed in testis and 221 other tissues |
Genevisiblei | Q3ZCT1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN260_HUMAN | |
Accessioni | Q3ZCT1Primary (citable) accession number: Q3ZCT1 Secondary accession number(s): Q0VF43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families