ZNF260

Functionⁱ

Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	27 – 49	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	55 – 77	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	83 – 105	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	136 – 158	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	164 – 186	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	192 – 214	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	220 – 242	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	248 – 270	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	276 – 298	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	304 – 326	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	332 – 354	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	360 – 382	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	388 – 412	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 260 Short name: Zfp-260
Gene namesⁱ	Name:ZNF260 Synonyms:ZFP260
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000254004.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13499 ZNF260
MIMⁱ	613749 gene
neXtProtⁱ	NX_Q3ZCT1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	339324
Open Targets More...OpenTargetsⁱ	ENSG00000254004
PharmGKBⁱ	PA145147548

Polymorphism and mutation databases

BioMutaⁱ	ZNF260
DMDMⁱ	215274187

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047320	1 – 412	Zinc finger protein 260Add BLAST		412

Proteomic databases

EPDⁱ	Q3ZCT1
PaxDbⁱ	Q3ZCT1
PeptideAtlas More...PeptideAtlasⁱ	Q3ZCT1
PRIDEⁱ	Q3ZCT1
ProteomicsDBⁱ	61911

PTM databases

iPTMnetⁱ	Q3ZCT1
PhosphoSitePlusⁱ	Q3ZCT1

Expressionⁱ

Inductionⁱ

Up-regulated by activation of alpha1-adrenergic receptors.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000254004 Expressed in 204 organ(s), highest expression level in testis
CleanExⁱ	HS_ZNF260
Genevisibleⁱ	Q3ZCT1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028806

HPAⁱ

HPA028806

Interactionⁱ

Subunit structureⁱ

Binds DNA. Interacts with GATA4 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NDEL1	Q9GZM8	3	EBI-10241410,EBI-928842

With

Entry

#Exp.

IntAct

Notes

NDEL1

Q9GZM8

3

EBI-10241410,EBI-928842

Protein-protein interaction databases

BioGridⁱ	130868, 3 interactors
IntActⁱ	Q3ZCT1, 3 interactors
STRINGⁱ	9606.ENSP00000429803

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3ZCT1
SMRⁱ	Q3ZCT1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	27 – 49	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	55 – 77	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	83 – 105	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	136 – 158	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	164 – 186	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	192 – 214	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	220 – 242	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	248 – 270	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	276 – 298	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	304 – 326	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	332 – 354	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	360 – 382	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	388 – 412	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150959
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q3ZCT1
OMAⁱ	YECGKAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q3ZCT1
TreeFamⁱ	TF341817

Family and domain databases

InterProⁱ	View protein in InterPro IPR017114 YY-1-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 12 hits
PIRSFⁱ	PIRSF037113 TF_Yin_yang, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 14 hits
SUPFAMⁱ	SSF57667 SSF57667, 8 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3ZCT1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIGMLESLQH ESDLLQHDQI HTGEKPYECN ECRKTFSLKQ NLVEHKKMHT 
        60         70         80         90        100
GEKSHECTEC GKVCSRVSSL TLHLRSHTGK KAYKCNKCGK AFSQKENFLS 
       110        120        130        140        150
HQKHHTGEKP YECEKVSIQM PTIIRHQKNH TGTKPYACKE CGKAFNGKAY 
       160        170        180        190        200
LTEHEKIHTG EKPFECNQCG RAFSQKQYLI KHQNIHTGKK PFKCSECGKA 
       210        220        230        240        250
FSQKENLIIH QRIHTGEKPY ECKGCGKAFI QKSSLIRHQR SHTGEKPYTC 
       260        270        280        290        300
KECGKAFSGK SNLTEHEKIH IGEKPYKCNE CGTIFRQKQY LIKHHNIHTG 
       310        320        330        340        350
EKPYECNKCG KAFSRITSLI VHVRIHTGDK PYECKVCGKA FCQSSSLTVH 
       360        370        380        390        400
MRSHTGEKPY GCNECGKAFS QFSTLALHMR IHTGEKPYQC SECGKAFSQK 
       410 
SHHIRHQRIH TH

Length:412

Mass (Da):47,222

Last modified:November 25, 2008 - v3

Checksum:ⁱD3943F148FD9C77C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC092295 Genomic DNA No translation available. BC042676 mRNA Translation: AAH42676.1 BC119003 mRNA Translation: AAI19004.1 BC122549 mRNA Translation: AAI22550.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33003.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001012774.1, NM_001012756.2 NP_001159508.1, NM_001166036.1 NP_001159509.1, NM_001166037.1 NP_001159510.1, NM_001166038.1 XP_011525199.1, XM_011526897.2 XP_016882230.1, XM_017026741.1
UniGeneⁱ	Hs.18103

Genome annotation databases

Ensemblⁱ	ENST00000523638; ENSP00000429803; ENSG00000254004 ENST00000588993; ENSP00000467219; ENSG00000254004 ENST00000592282; ENSP00000464964; ENSG00000254004 ENST00000593142; ENSP00000465834; ENSG00000254004
GeneIDⁱ	339324
KEGGⁱ	hsa:339324
UCSC genome browser More...UCSCⁱ	uc002oee.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3ZCT1	ZNF260 isoform 1		PANTR		412	UniRef100_Q3ZCT1
Zinc finger protein 260		PONAB		412

Protein	Similar proteins		Species	Score	Length	Source
Q3ZCT1	ZNF260 isoform 1		PANTR		412	UniRef90_Q3ZCT1
Zinc finger protein 260		PONAB		412
Uncharacterized protein		MUSPF		436
Uncharacterized protein		RHIRO		412
Uncharacterized protein		RHIBE		412
+82

Protein	Similar proteins		Species	Score	Length	Source
Q3ZCT1	ZNF260 isoform 1		PANTR		412	UniRef50_Q3ZCT1
Zinc finger protein 260		PONAB		412
Uncharacterized protein		MUSPF		436
Uncharacterized protein		CHLSB		412
Uncharacterized protein		MANLE		412
+85

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC092295 Genomic DNA No translation available. BC042676 mRNA Translation: AAH42676.1 BC119003 mRNA Translation: AAI19004.1 BC122549 mRNA Translation: AAI22550.1
CCDSⁱ	CCDS33003.1
RefSeqⁱ	NP_001012774.1, NM_001012756.2 NP_001159508.1, NM_001166036.1 NP_001159509.1, NM_001166037.1 NP_001159510.1, NM_001166038.1 XP_011525199.1, XM_011526897.2 XP_016882230.1, XM_017026741.1
UniGeneⁱ	Hs.18103

3D structure databases

ProteinModelPortalⁱ	Q3ZCT1
SMRⁱ	Q3ZCT1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	130868, 3 interactors
IntActⁱ	Q3ZCT1, 3 interactors
STRINGⁱ	9606.ENSP00000429803

PTM databases

iPTMnetⁱ	Q3ZCT1
PhosphoSitePlusⁱ	Q3ZCT1

Polymorphism and mutation databases

BioMutaⁱ	ZNF260
DMDMⁱ	215274187

Proteomic databases

EPDⁱ	Q3ZCT1
PaxDbⁱ	Q3ZCT1
PeptideAtlasⁱ	Q3ZCT1
PRIDEⁱ	Q3ZCT1
ProteomicsDBⁱ	61911

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000523638; ENSP00000429803; ENSG00000254004 ENST00000588993; ENSP00000467219; ENSG00000254004 ENST00000592282; ENSP00000464964; ENSG00000254004 ENST00000593142; ENSP00000465834; ENSG00000254004
GeneIDⁱ	339324
KEGGⁱ	hsa:339324
UCSCⁱ	uc002oee.3 human

Organism-specific databases

CTDⁱ	339324
DisGeNETⁱ	339324
EuPathDBⁱ	HostDB:ENSG00000254004.6
GeneCardsⁱ	ZNF260
HGNCⁱ	HGNC:13499 ZNF260
HPAⁱ	HPA028806
MIMⁱ	613749 gene
neXtProtⁱ	NX_Q3ZCT1
OpenTargetsⁱ	ENSG00000254004
PharmGKBⁱ	PA145147548
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00930000150959
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q3ZCT1
OMAⁱ	YECGKAS
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q3ZCT1
TreeFamⁱ	TF341817

Miscellaneous databases

GenomeRNAiⁱ	339324
Protein Ontology More...PROⁱ	PR:Q3ZCT1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000254004 Expressed in 204 organ(s), highest expression level in testis
CleanExⁱ	HS_ZNF260
Genevisibleⁱ	Q3ZCT1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR017114 YY-1-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 12 hits
PIRSFⁱ	PIRSF037113 TF_Yin_yang, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 14 hits
SUPFAMⁱ	SSF57667 SSF57667, 8 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN260_HUMAN
Accessionⁱ	Q3ZCT1Primary (citable) accession number: Q3ZCT1 Secondary accession number(s): Q0VF43
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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Annotation systems

Supporting data

UniProtKB - Q3ZCT1 (ZN260_HUMAN)

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Zinc finger protein 260

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ