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Entry version 85 (18 Sep 2019)
Sequence version 2 (18 May 2010)
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Protein

Annexin-2 receptor

Gene

ANXA2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

Caution

PubMed:16895901 reports that it is a type I membrane protein. However, no clear transmembrane region is detected by prediction methods, suggesting that its localization at the plasma membrane is unsure.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Annexin-2 receptor
Alternative name(s):
Annexin II receptor
Short name:
AXIIR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANXA2R
Synonyms:AX2R, C5orf39
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33463 ANXA2R

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611296 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3ZCQ2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
389289

Open Targets

More...
OpenTargetsi
ENSG00000177721

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162380171

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q3ZCQ2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANXA2R

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002957271 – 193Annexin-2 receptorAdd BLAST193

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3ZCQ2

PeptideAtlas

More...
PeptideAtlasi
Q3ZCQ2

PRoteomics IDEntifications database

More...
PRIDEi
Q3ZCQ2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61907

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3ZCQ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3ZCQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4+ and CD8+ T-cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177721 Expressed in 120 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3ZCQ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051482

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CNOT1A5YKK63EBI-21258284,EBI-1222758

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
133074, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q3ZCQ2, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000315915

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J4VK Eukaryota
ENOG41115P8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009290

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169180

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3ZCQ2

Identification of Orthologs from Complete Genome Data

More...
OMAi
ICGAKQP

Database of Orthologous Groups

More...
OrthoDBi
1501144at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3ZCQ2

TreeFam database of animal gene trees

More...
TreeFami
TF342039

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031449 ANXA2R

The PANTHER Classification System

More...
PANTHERi
PTHR38820 PTHR38820, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15721 ANXA2R, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3ZCQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQHFLGCVK RAWDSAEVAP EPQPPPIVSS EDRGPWPLPL YPVLGEYSLD
60 70 80 90 100
SCDLGLLSSP CWRLPGVYWQ NGLSPGVQST LEPSTAKPTE FSWPGTQKQQ
110 120 130 140 150
EAPVEEVGQA EEPDRLRLQQ LPWSSPLHPW DRQQDTEVCD SGCLLERRHP
160 170 180 190
PALQPWRHLP GFSDCLEWIL RVGFAAFSVL WACCSRICGA KQP
Length:193
Mass (Da):21,682
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BBC734AB14CE32F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033348119Q → R1 PublicationCorresponds to variant dbSNP:rs1054428Ensembl.1
Natural variantiVAR_033349186R → W. Corresponds to variant dbSNP:rs10971Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY032883 mRNA Translation: AAK52335.1
AC025171 Genomic DNA No translation available.
BC067873 mRNA Translation: AAH67873.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34153.1

NCBI Reference Sequences

More...
RefSeqi
NP_001014301.1, NM_001014279.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314890; ENSP00000315915; ENSG00000177721
ENST00000616064; ENSP00000479862; ENSG00000177721

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
389289

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389289

UCSC genome browser

More...
UCSCi
uc003jnf.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032883 mRNA Translation: AAK52335.1
AC025171 Genomic DNA No translation available.
BC067873 mRNA Translation: AAH67873.1
CCDSiCCDS34153.1
RefSeqiNP_001014301.1, NM_001014279.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi133074, 1 interactor
IntActiQ3ZCQ2, 6 interactors
STRINGi9606.ENSP00000315915

PTM databases

iPTMnetiQ3ZCQ2
PhosphoSitePlusiQ3ZCQ2

Polymorphism and mutation databases

BioMutaiANXA2R

Proteomic databases

PaxDbiQ3ZCQ2
PeptideAtlasiQ3ZCQ2
PRIDEiQ3ZCQ2
ProteomicsDBi61907

Genome annotation databases

EnsembliENST00000314890; ENSP00000315915; ENSG00000177721
ENST00000616064; ENSP00000479862; ENSG00000177721
GeneIDi389289
KEGGihsa:389289
UCSCiuc003jnf.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389289
DisGeNETi389289

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANXA2R
HGNCiHGNC:33463 ANXA2R
HPAiHPA051482
MIMi611296 gene
neXtProtiNX_Q3ZCQ2
OpenTargetsiENSG00000177721
PharmGKBiPA162380171

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J4VK Eukaryota
ENOG41115P8 LUCA
GeneTreeiENSGT00390000009290
HOGENOMiHOG000169180
InParanoidiQ3ZCQ2
OMAiICGAKQP
OrthoDBi1501144at2759
PhylomeDBiQ3ZCQ2
TreeFamiTF342039

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
389289
PharosiQ3ZCQ2

Protein Ontology

More...
PROi
PR:Q3ZCQ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177721 Expressed in 120 organ(s), highest expression level in blood
GenevisibleiQ3ZCQ2 HS

Family and domain databases

InterProiView protein in InterPro
IPR031449 ANXA2R
PANTHERiPTHR38820 PTHR38820, 1 hit
PfamiView protein in Pfam
PF15721 ANXA2R, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAX2R_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3ZCQ2
Secondary accession number(s): Q8NHX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 85 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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