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Entry version 102 (08 May 2019)
Sequence version 5 (06 Feb 2013)
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Protein

Otogelin-like protein

Gene

OTOGL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Otogelin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OTOGL
Synonyms:C12orf64
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26901 OTOGL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614925 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3ZCN5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 84B (DFNB84B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic deafness characterized by congenital, non-progressive, sensorineural, symmetric hearing loss. Vestibular hypofunction is rarely observed.
Related information in OMIM

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
283310

MalaCards human disease database

More...
MalaCardsi
OTOGL
MIMi614944 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OTOGL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
449081296

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031676523 – 2332Otogelin-like proteinAdd BLAST2310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi136 ↔ 144By similarity
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi464N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi817N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi867N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1583N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2177N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2240 ↔ 2296By similarity
Disulfide bondi2261 ↔ 2310By similarity
Disulfide bondi2272 ↔ 2327By similarity
Disulfide bondi2276 ↔ 2329By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3ZCN5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3ZCN5

PeptideAtlas

More...
PeptideAtlasi
Q3ZCN5

PRoteomics IDEntifications database

More...
PRIDEi
Q3ZCN5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61905

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q3ZCN5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3ZCN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3ZCN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in fetal inner ear and heart. Low levels in fetal skeletal muscle, kidney, spleen and colon. Not detected in fetal liver, lung, brain, nor in fetal stomach. In adult tissues, highest levels in brain, kidney, heart and retina. Relatively low levels in lung, spleen and duodenum. Not detected in adult skeletal muscle, liver, nor testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165899 Expressed in 87 organ(s), highest expression level in right atrium auricular region

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3ZCN5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3ZCN5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040364
HPA053392

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000400895

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3ZCN5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 326VWFD 1PROSITE-ProRule annotationAdd BLAST214
Domaini381 – 434TIL 1Add BLAST54
Domaini473 – 683VWFD 2PROSITE-ProRule annotationAdd BLAST211
Domaini736 – 791TIL 2Add BLAST56
Domaini938 – 1141VWFD 3PROSITE-ProRule annotationAdd BLAST204
Domaini1514 – 1734VWFD 4PROSITE-ProRule annotationAdd BLAST221
Domaini2240 – 2332CTCKPROSITE-ProRule annotationAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1908 – 2095Cys-richAdd BLAST188

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the otogelin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216 Eukaryota
ENOG410XNSK LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115301

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3ZCN5

TreeFam database of animal gene trees

More...
TreeFami
TF330609

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007934 AbfB_ABD
IPR036195 AbfB_ABD_sf
IPR006207 Cys_knot_C
IPR030110 Otogl
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D

The PANTHER Classification System

More...
PANTHERi
PTHR11339:SF225 PTHR11339:SF225, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05270 AbfB, 1 hit
PF08742 C8, 4 hits
PF01826 TIL, 1 hit
PF00094 VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00215 VWC_out, 2 hits
SM00216 VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110221 SSF110221, 1 hit
SSF57567 SSF57567, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01225 CTCK_2, 1 hit
PS51233 VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q3ZCN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPWSIFLLH VLLFSLQEYI CASSILMGTS KNGFNENRQK RALLAAQFEA
60 70 80 90 100
TSPRYFFHDA INWGESKIKG SCPYECLNGA FCSKTGTCDC QIFQALGTRC
110 120 130 140 150
QIIPNMGNGR DGICKTWGQY HFETFDGIYY YFPGNCSYIF AKDCGDLEPR
160 170 180 190 200
YTVWVHNSPK CLGSVYSCYR SISLFFSNQE EIRIYGHEIK KNGISLTLPQ
210 220 230 240 250
TIGQIFIEKL ADYILVKTTF GFSLAWDGIS GIYLKLSEDH KGKSCGLCGN
260 270 280 290 300
YNDIQSDDFI ILQEDYTEDI AMFANSWSVQ TPDDTKCVLT PSDFPNPCSS
310 320 330 340 350
GMPAFEAIFF KCQILLQFPF LSCHEYIDPY LYIASCVNDL CKTDDDETYC
360 370 380 390 400
RAATEYARAC SHAGYPIQDW RDDFPACTDK CDDSFVHRDC ISCCPPTCTF
410 420 430 440 450
EKQCLGSNLH CLDGCYCPDG LVMDNGTCIS LENCPCGFHG LAYSVGSKIE
460 470 480 490 500
QECTECVCVG GVWNCTEQDC PVQCSVVGDS HFTTFDGRHY SFIGMCQYIL
510 520 530 540 550
VKGTGKDKFT ITLQKAPCEQ NLGLVCLQSI TLILEDDFNK QVTLGRGGQI
560 570 580 590 600
LTSPNQGFNL NGIVEIQTLS SLFILLKTTF GLKILFAIDG ERIYIQLTSA
610 620 630 640 650
WKRRTLGLCG TFNGNIRDDF LSPSGMIEGT PQLHANAWRV SSTCFAPVHV
660 670 680 690 700
PVVDPCNINQ QNIGYAAHCD VIHQELFAPC HIYISPGLYY QLCRHDACKC
710 720 730 740 750
GSSCLCNALA HYAYLCGQHG VPIDFRTQIS FCAVVCQKGM LYHHCSSFCL
760 770 780 790 800
HSCISLSSPE QCSDDCAEGC NCPEGKFYED TLNFCVPIFH CRCHYRGSVY
810 820 830 840 850
QPGELIPTPS GLCQCSNGTV KCDELATPSA VHICPEGKEY FDCRFPDPEL
860 870 880 890 900
PAGGVNCETT CANLAMNFTC TPSSPCISGC VCAPGMAEHR GKCYVPESCP
910 920 930 940 950
CIWKDWEYLS GEVIATPCYT CVCRRGMFNC TYYPCPAVCT IYGDRHYYSF
960 970 980 990 1000
DGLEYDYISD CQVFLIKSAD DSDISVIAQN KKCFDNDIVC SKSVLISVGD
1010 1020 1030 1040 1050
TEIYLNDTPY KQKQSGFFLE NKSTYQLWKA GYYIVVYFPE KDITILWDRK
1060 1070 1080 1090 1100
TTIHIKVGPQ WKNKLSGLCG NFDKCTSNDM TTSNNLEVRN ARVFGDSWAL
1110 1120 1130 1140 1150
GQCESPDETI KPCEAHQNKF PYAKKECSIL YSDIFASCRN VIDVTSFAKN
1160 1170 1180 1190 1200
CHEDTCNCNL GGDCECLCTS IAAYAYKCCQ EGISIHWRSS TVCSLDCEYY
1210 1220 1230 1240 1250
NEGLGEGPYM LASYGQSGLV LGANMTSRSV FCLPRSSVHT SLFFYFMITP
1260 1270 1280 1290 1300
GLFKEKVSSL ALVSLESAER PNYFLYVHDN DTLSLELWEA NSAFHRRATF
1310 1320 1330 1340 1350
FHHQGLWIPG YSAFELYSKK GFFIIFTDSS VKASKYDDSE EFKHSSSFSI
1360 1370 1380 1390 1400
EEIQAAVPYR KMCEWRYEPC ATPCFKTCSD PEALACKFLP PVEGCLPYCP
1410 1420 1430 1440 1450
KNMILDEVTL KCVYPRDCIP VIPTEPTLMP PAKPTVPITV FDMLTPTTGL
1460 1470 1480 1490 1500
ECEPQKFDPV YDCSQYICLN MEWQLYNWSL NCPKDVEMPD CGFRGRPVQV
1510 1520 1530 1540 1550
NSDICCPEWE CPCRCSMLSE LSIITFDGNN AALYSMASYI LVRIPGEIIV
1560 1570 1580 1590 1600
AHIEKCSMNQ NGNSLKKLAP SGRISGLCFK KLNVTTPIHK IIVNRLARKV
1610 1620 1630 1640 1650
EVDSIVVPLP FSSQELSIED SGSMYVITTP AGLIIKWSHL TGIIDIHFGF
1660 1670 1680 1690 1700
RFNLSSYTEG LCGICNEDPD DDLRMQNGTI ITNMEDIGLF IESWEIEKSF
1710 1720 1730 1740 1750
EVTMRRPVRN CTEHDCSQCI DLLNRRIFIP CHDKVSPEDF CEKMWINYTY
1760 1770 1780 1790 1800
FWNYECDALS AYVALCNKFD ICIQWRTPDY CSLSCPEGKE YQPCVRPCEA
1810 1820 1830 1840 1850
RTCLNQWFYG HTSCLNLRED CVCKVGTILH RPHSAQCIPE KECACTDSED
1860 1870 1880 1890 1900
QPRTAGEIWN GGIDECTLYK CLENGSIIPI EPDCDEEPTP VCEREAEVVM
1910 1920 1930 1940 1950
GIIDKWTCCS KEVCGCDTTL CETSIPTCTN SQKLIVGHSP LSCCPQYKCE
1960 1970 1980 1990 2000
CDPLKCPSIS TPECREDQFM IQVRQEEPCC FSPFCVCESC TKPVPLCHDG
2010 2020 2030 2040 2050
EFLTVDLNST HFCCPQYYCV CEPNLCPMPL LNCAEDMNLV KENVSGQCCP
2060 2070 2080 2090 2100
TWHCECNCEN LIMPTCEVGE FTAIDHNFQS DCGCIQYLCE KDDVCVFQEV
2110 2120 2130 2140 2150
SVLNPGQSMI KYLEEDFCYA IECLEEKDNH TGFHTLNFTL VNCSKKCDVH
2160 2170 2180 2190 2200
QVYTPSPSDY GCCGTCKNVS CKFHMENGTS VVYAVGSTWH YNCTTYECVK
2210 2220 2230 2240 2250
TDEGAIILNY TMVCPPFNET ECKMNEGIVK LYNEGCCKIC KREERICQKV
2260 2270 2280 2290 2300
IIKSVIRKQD CMSQSPINVA SCDGKCPSAT IYNINIESHL RFCKCCRENG
2310 2320 2330
VRNLSVPLYC SGNGTEIMYT LQEPIDCTCQ WN
Length:2,332
Mass (Da):262,091
Last modified:February 6, 2013 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD43BCCDB7727CB80
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSS2A0A0A0MSS2_HUMAN
Otogelin-like protein
OTOGL
2,344Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YF04A0A2R8YF04_HUMAN
Otogelin-like protein
OTOGL
2,308Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXL6H7BXL6_HUMAN
Otogelin-like protein
OTOGL
752Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIL4H0YIL4_HUMAN
Otogelin-like protein
OTOGL
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIF7H0YIF7_HUMAN
Otogelin-like protein
OTOGL
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCH1A0A2R8YCH1_HUMAN
Otogelin-like protein
OTOGL
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04877 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11376 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2062I → V in BAC04877 (PubMed:14702039).Curated1
Sequence conflicti2062I → V in AAI01018 (PubMed:15489334).Curated1
Sequence conflicti2062I → V in AAI01019 (PubMed:15489334).Curated1
Sequence conflicti2120A → T in BAC04877 (PubMed:14702039).Curated1
Sequence conflicti2120A → T in BAC11376 (PubMed:14702039).Curated1
Sequence conflicti2120A → T in AAI01018 (PubMed:15489334).Curated1
Sequence conflicti2120A → T in AAI01019 (PubMed:15489334).Curated1
Sequence conflicti2225N → S in BAC11376 (PubMed:14702039).Curated1
Sequence conflicti2225N → S in AAI01018 (PubMed:15489334).Curated1
Sequence conflicti2225N → S in AAI01019 (PubMed:15489334).Curated1
Sequence conflicti2253K → E in BAC04877 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0690401378C → R1 PublicationCorresponds to variant dbSNP:rs768182016Ensembl.1
Natural variantiVAR_0383882276C → F in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC078817 Genomic DNA No translation available.
AC083812 Genomic DNA No translation available.
AC092945 Genomic DNA No translation available.
AK075060 mRNA Translation: BAC11376.1 Different initiation.
AK096852 mRNA Translation: BAC04877.1 Different initiation.
BC101017 mRNA Translation: AAI01018.3
BC101018 mRNA Translation: AAI01019.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000547103; ENSP00000447211; ENSG00000165899

UCSC genome browser

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UCSCi
uc058rih.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078817 Genomic DNA No translation available.
AC083812 Genomic DNA No translation available.
AC092945 Genomic DNA No translation available.
AK075060 mRNA Translation: BAC11376.1 Different initiation.
AK096852 mRNA Translation: BAC04877.1 Different initiation.
BC101017 mRNA Translation: AAI01018.3
BC101018 mRNA Translation: AAI01019.2

3D structure databases

SMRiQ3ZCN5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000400895

PTM databases

iPTMnetiQ3ZCN5
PhosphoSitePlusiQ3ZCN5

Polymorphism and mutation databases

BioMutaiOTOGL
DMDMi449081296

Proteomic databases

jPOSTiQ3ZCN5
PaxDbiQ3ZCN5
PeptideAtlasiQ3ZCN5
PRIDEiQ3ZCN5
ProteomicsDBi61905
TopDownProteomicsiQ3ZCN5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000547103; ENSP00000447211; ENSG00000165899
UCSCiuc058rih.1 human

Organism-specific databases

DisGeNETi283310

GeneCards: human genes, protein and diseases

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GeneCardsi
OTOGL

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0018423
HGNCiHGNC:26901 OTOGL
HPAiHPA040364
HPA053392
MalaCardsiOTOGL
MIMi614925 gene
614944 phenotype
neXtProtiNX_Q3ZCN5
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
ENOG410XNSK LUCA
HOGENOMiHOG000115301
InParanoidiQ3ZCN5
TreeFamiTF330609

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
OTOGL human

Protein Ontology

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PROi
PR:Q3ZCN5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165899 Expressed in 87 organ(s), highest expression level in right atrium auricular region
ExpressionAtlasiQ3ZCN5 baseline and differential
GenevisibleiQ3ZCN5 HS

Family and domain databases

InterProiView protein in InterPro
IPR007934 AbfB_ABD
IPR036195 AbfB_ABD_sf
IPR006207 Cys_knot_C
IPR030110 Otogl
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PANTHERiPTHR11339:SF225 PTHR11339:SF225, 1 hit
PfamiView protein in Pfam
PF05270 AbfB, 1 hit
PF08742 C8, 4 hits
PF01826 TIL, 1 hit
PF00094 VWD, 4 hits
SMARTiView protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00215 VWC_out, 2 hits
SM00216 VWD, 4 hits
SUPFAMiSSF110221 SSF110221, 1 hit
SSF57567 SSF57567, 4 hits
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
PS51233 VWFD, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOTOGL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3ZCN5
Secondary accession number(s): F8W0C3
, Q495U8, Q8N8G5, Q8NC28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2013
Last modified: May 8, 2019
This is version 102 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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