UniProtKB - Q3ZC84 (CNDP2_BOVIN)
Cytosolic non-specific dipeptidase
CNDP2
Functioni
Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity).
Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism. Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis. Plays a role in the regulation of cell cycle arrest and apoptosis (By similarity).
By similarityCatalytic activityi
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.By similarity EC:3.4.13.18
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 99 | Manganese 2; via tele nitrogenBy similarity | 1 | |
Active sitei | 101 | By similarity | 1 | |
Metal bindingi | 132 | Manganese 1By similarity | 1 | |
Metal bindingi | 132 | Manganese 2By similarity | 1 | |
Active sitei | 166 | Proton acceptorBy similarity | 1 | |
Metal bindingi | 167 | Manganese 1By similarity | 1 | |
Metal bindingi | 195 | Manganese 2By similarity | 1 | |
Binding sitei | 195 | Substrate; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 228 | Substrate; shared with homodimeric partnerBy similarity | 1 | |
Sitei | 228 | Important for catalytic activityBy similarity | 1 | |
Binding sitei | 330 | Substrate; shared with homodimeric partnerBy similarity | 1 | |
Binding sitei | 343 | SubstrateBy similarity | 1 | |
Binding sitei | 417 | Substrate; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 445 | Manganese 1; via tele nitrogenBy similarity | 1 | |
Binding sitei | 445 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- alanylglutamate dipeptidase activity Source: UniProtKB-EC
- carboxypeptidase activity Source: UniProtKB-KW
- dipeptidase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- metallodipeptidase activity Source: InterPro
- peptidase activity Source: GO_Central
GO - Biological processi
- proteolysis Source: GO_Central
Keywordsi
Molecular function | Carboxypeptidase, Hydrolase, Metalloprotease, Protease |
Ligand | Manganese, Metal-binding |
Protein family/group databases
MEROPSi | M20.005 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytosolic non-specific dipeptidase (EC:3.4.13.18By similarity)Alternative name(s): CNDP dipeptidase 2 Threonyl dipeptidaseBy similarity |
Gene namesi | Name:CNDP2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000009841 |
VGNCi | VGNC:27494, CNDP2 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleoplasm Source: Ensembl
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284970 | 1 – 475 | Cytosolic non-specific dipeptidaseAdd BLAST | 475 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 58 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q3ZC84 |
PeptideAtlasi | Q3ZC84 |
PRIDEi | Q3ZC84 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000009841, Expressed in kidney and 98 other tissues |
ExpressionAtlasi | Q3ZC84, baseline and differential |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000031070 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 167 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2276, Eukaryota |
GeneTreei | ENSGT00940000156500 |
HOGENOMi | CLU_029469_3_1_1 |
InParanoidi | Q3ZC84 |
OMAi | HITIPGF |
OrthoDBi | 733473at2759 |
TreeFami | TF300633 |
Family and domain databases
InterProi | View protein in InterPro IPR001261, ArgE/DapE_CS IPR017153, CNDP/DUG1 IPR002933, Peptidase_M20 IPR011650, Peptidase_M20_dimer |
Pfami | View protein in Pfam PF07687, M20_dimer, 1 hit PF01546, Peptidase_M20, 1 hit |
PIRSFi | PIRSF037242, CNDP_dipeptidase, 1 hit |
PROSITEi | View protein in PROSITE PS00759, ARGE_DAPE_CPG2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSALTTLFKY VDENQDRYVK KLAEWVAIQS VSAWPEKRGE IRRMMEVAAA
60 70 80 90 100
DIKQLGGSVQ LVDIGTQKLP DGSEIPLPPI LLGKLGSDPQ KKTVCIYGHL
110 120 130 140 150
DVQPAALEDG WDSEPFTLVE RDGKLFGRGA TDDKGPVAGW INALEAFQKT
160 170 180 190 200
KQEVPVNVRF CLEGMEESGS EGLDALIFAQ KDAFFKDVDY VCISDNYWLG
210 220 230 240 250
KNKPCITYGL RGICYFFIEV ECSDKDLHSG VYGGSVHEAM TDLIMLMGCL
260 270 280 290 300
MDKKGKILIP GISEAVAPVT EEELELYDKI DFDLEEYARD VGAGTLLHGC
310 320 330 340 350
KKDILMHRWR YPSLSLHGIE GAFSGSGAKT VIPRKVVGKF SIRLVPNMTP
360 370 380 390 400
EVVSEQVTSY LTKKFAELHS PNKFKVYMGH GGKPWVSDFN HPHYLAGRRA
410 420 430 440 450
LKTVFGVEPD LTREGGSIPV TLTFQEATGK NVMLLPVGSA DDGAHSQNEK
460 470
LNRRNYIEGT KMLAAYLYEV SQLKD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1LW01 | A0A3Q1LW01_BOVIN | Cytosolic non-specific dipeptidase | CNDP2 | 474 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102835 mRNA Translation: AAI02836.1 |
RefSeqi | NP_001030280.1, NM_001035108.1 XP_005223983.1, XM_005223926.2 XP_005223984.1, XM_005223927.3 |
Genome annotation databases
Ensembli | ENSBTAT00000031107; ENSBTAP00000031070; ENSBTAG00000009841 |
GeneIDi | 512626 |
KEGGi | bta:512626 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102835 mRNA Translation: AAI02836.1 |
RefSeqi | NP_001030280.1, NM_001035108.1 XP_005223983.1, XM_005223926.2 XP_005223984.1, XM_005223927.3 |
3D structure databases
AlphaFoldDBi | Q3ZC84 |
SMRi | Q3ZC84 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000031070 |
Protein family/group databases
MEROPSi | M20.005 |
Proteomic databases
PaxDbi | Q3ZC84 |
PeptideAtlasi | Q3ZC84 |
PRIDEi | Q3ZC84 |
Genome annotation databases
Ensembli | ENSBTAT00000031107; ENSBTAP00000031070; ENSBTAG00000009841 |
GeneIDi | 512626 |
KEGGi | bta:512626 |
Organism-specific databases
CTDi | 55748 |
VEuPathDBi | HostDB:ENSBTAG00000009841 |
VGNCi | VGNC:27494, CNDP2 |
Phylogenomic databases
eggNOGi | KOG2276, Eukaryota |
GeneTreei | ENSGT00940000156500 |
HOGENOMi | CLU_029469_3_1_1 |
InParanoidi | Q3ZC84 |
OMAi | HITIPGF |
OrthoDBi | 733473at2759 |
TreeFami | TF300633 |
Gene expression databases
Bgeei | ENSBTAG00000009841, Expressed in kidney and 98 other tissues |
ExpressionAtlasi | Q3ZC84, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001261, ArgE/DapE_CS IPR017153, CNDP/DUG1 IPR002933, Peptidase_M20 IPR011650, Peptidase_M20_dimer |
Pfami | View protein in Pfam PF07687, M20_dimer, 1 hit PF01546, Peptidase_M20, 1 hit |
PIRSFi | PIRSF037242, CNDP_dipeptidase, 1 hit |
PROSITEi | View protein in PROSITE PS00759, ARGE_DAPE_CPG2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CNDP2_BOVIN | |
Accessioni | Q3ZC84Primary (citable) accession number: Q3ZC84 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | September 27, 2005 | |
Last modified: | May 25, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families