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Protein

Cysteine-rich PDZ-binding protein

Gene

CRIPT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich PDZ-binding protein
Alternative name(s):
Cysteine-rich interactor of PDZ three
Short name:
Cysteine-rich interactor of PDZ3
Gene namesi
Name:CRIPT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:27712 CRIPT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003145621 – 101Cysteine-rich PDZ-binding proteinAdd BLAST101

Proteomic databases

PaxDbiQ3ZC66

Expressioni

Gene expression databases

BgeeiENSBTAG00000015723

Interactioni

Subunit structurei

Interacts with TUBB1. Interacts strongly with the PDZ3 domain of members of the DLG4 family. Associates with microtubules (By similarity). Interacts with DLG4.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020872

Structurei

3D structure databases

ProteinModelPortaliQ3ZC66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 101Sufficient for interaction with DLG41 Publication7
Regioni98 – 101PDZ3-binding4

Sequence similaritiesi

Belongs to the CRIPT family.Curated

Phylogenomic databases

eggNOGiKOG3476 Eukaryota
ENOG4111RAI LUCA
GeneTreeiENSGT00390000002260
HOGENOMiHOG000242625
HOVERGENiHBG097641
InParanoidiQ3ZC66
OMAiKYCHGCA
OrthoDBiEOG091G0YCT
TreeFamiTF300144

Family and domain databases

InterProiView protein in InterPro
IPR019367 PDZ-binding_CRIPT
PANTHERiPTHR11805 PTHR11805, 1 hit
PfamiView protein in Pfam
PF10235 Cript, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ZC66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCEKCEKKL GTVITPDTWK DGARNTTESG GRKLNENKAL TSKKARFDPY
60 70 80 90 100
GKNKFSTCRI CKSSVHQPGS HYCQGCAYKK GICAMCGKKV LDTKNYKQTS

V
Length:101
Mass (Da):11,216
Last modified:September 27, 2005 - v1
Checksum:i161B0F4CA87DFBAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102887 mRNA Translation: AAI02888.1
RefSeqiNP_001029975.1, NM_001034803.2
UniGeneiBt.49354

Genome annotation databases

EnsembliENSBTAT00000020872; ENSBTAP00000020872; ENSBTAG00000015723
GeneIDi617723
KEGGibta:617723

Similar proteinsi

Entry informationi

Entry nameiCRIPT_BOVIN
AccessioniPrimary (citable) accession number: Q3ZC66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 27, 2005
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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