We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q3ZBW2 (HAOX2_BOVIN)
Protein
2-Hydroxyacid oxidase 2
Gene
HAO2
Organism
Bos taurus (Bovine)
Status
Functioni
Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, to the correspondong 2-oxoacids. Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation. Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2.
By similarityCatalytic activityi
- EC:1.1.3.15By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
Cofactori
FMNBy similarity
: fatty acid metabolism Pathwayi
This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 106 | FMNBy similarity | 1 | |
Binding sitei | 128 | FMNBy similarity | 1 | |
Binding sitei | 130 | 2-oxocarboxylatePROSITE-ProRule annotation | 1 | |
Binding sitei | 156 | FMNBy similarity | 1 | |
Binding sitei | 165 | 2-oxocarboxylatePROSITE-ProRule annotation | 1 | |
Binding sitei | 224 | FMNBy similarity | 1 | |
Active sitei | 248 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Binding sitei | 251 | 2-oxocarboxylatePROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 77 – 79 | FMNBy similarity | 3 | |
Nucleotide bindingi | 279 – 283 | FMNBy similarity | 5 | |
Nucleotide bindingi | 302 – 303 | FMNBy similarity | 2 |
GO - Molecular functioni
- (S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
- FMN binding Source: InterPro
GO - Biological processi
- fatty acid oxidation Source: Ensembl
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | Flavoprotein, FMN |
Enzyme and pathway databases
Reactomei | R-BTA-390918, Peroxisomal lipid metabolism |
UniPathwayi | UPA00199 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-Hydroxyacid oxidase 2 (EC:1.1.3.15By similarity)Short name: HAOX2 Alternative name(s): (S)-2-hydroxy-acid oxidase, peroxisomal |
Gene namesi | Name:HAO2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000000123 |
VGNCi | VGNC:29748, HAO2 |
Subcellular locationi
Peroxisome
- Peroxisome By similarity
Peroxisome
- peroxisomal matrix Source: Ensembl
Keywords - Cellular componenti
PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000285088 | 1 – 353 | 2-Hydroxyacid oxidase 2Add BLAST | 353 |
Proteomic databases
PaxDbi | Q3ZBW2 |
PeptideAtlasi | Q3ZBW2 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000000123, Expressed in kidney and 30 other tissues |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000000134 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 353 | FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST | 352 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 351 – 353 | Microbody targeting signalSequence analysis | 3 |
Sequence similaritiesi
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0538, Eukaryota |
GeneTreei | ENSGT00390000018717 |
HOGENOMi | CLU_020639_0_0_1 |
InParanoidi | Q3ZBW2 |
OMAi | FQYEIYL |
OrthoDBi | 879633at2759 |
TreeFami | TF313363 |
Family and domain databases
CDDi | cd02809, alpha_hydroxyacid_oxid_FMN, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR012133, Alpha-hydoxy_acid_DH_FMN IPR000262, FMN-dep_DH IPR037396, FMN_HAD IPR008259, FMN_hydac_DH_AS |
Pfami | View protein in Pfam PF01070, FMN_dh, 1 hit |
PIRSFi | PIRSF000138, Al-hdrx_acd_dh, 1 hit |
PROSITEi | View protein in PROSITE PS00557, FMN_HYDROXY_ACID_DH_1, 1 hit PS51349, FMN_HYDROXY_ACID_DH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3ZBW2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLVCLTDFR EHAREHLSKS TWDFIEGGAD DCCTRDENMA AFKKIRLRPR
60 70 80 90 100
YLKDVSKVDM RTTIQGAEIS APICIAPTGF HRLAWPDGEM STARAAQAAS
110 120 130 140 150
ICYITSTYAS CSLEDIVAAA PRGLRWFQLY VHPNRQINKQ MIQKVESLGF
160 170 180 190 200
KALVITVDVP KVGNRRNDIT NQVDLMKKLL LKDLGSPEMG NVMPYFQMSP
210 220 230 240 250
IDPSICWEDL SWFQSMTRLP IILKGILTKE DAELAVKHNV HGIIVSNHGG
260 270 280 290 300
RQLDEVPASI DALTEVVAAV KGKVEVYLDG GIRTGNDVLK ALALGAKCVF
310 320 330 340 350
VGRPILWGLA YKGEHGVKEV LDILKNEFHT SMTLTGCRSV AEINQDLIQF
SRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC103070 mRNA Translation: AAI03071.1 |
RefSeqi | NP_001030243.1, NM_001035071.1 XP_005204069.1, XM_005204012.3 |
Genome annotation databases
Ensembli | ENSBTAT00000000134; ENSBTAP00000000134; ENSBTAG00000000123 |
GeneIDi | 509481 |
KEGGi | bta:509481 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC103070 mRNA Translation: AAI03071.1 |
RefSeqi | NP_001030243.1, NM_001035071.1 XP_005204069.1, XM_005204012.3 |
3D structure databases
SMRi | Q3ZBW2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000000134 |
Proteomic databases
PaxDbi | Q3ZBW2 |
PeptideAtlasi | Q3ZBW2 |
Genome annotation databases
Ensembli | ENSBTAT00000000134; ENSBTAP00000000134; ENSBTAG00000000123 |
GeneIDi | 509481 |
KEGGi | bta:509481 |
Organism-specific databases
CTDi | 51179 |
VEuPathDBi | HostDB:ENSBTAG00000000123 |
VGNCi | VGNC:29748, HAO2 |
Phylogenomic databases
eggNOGi | KOG0538, Eukaryota |
GeneTreei | ENSGT00390000018717 |
HOGENOMi | CLU_020639_0_0_1 |
InParanoidi | Q3ZBW2 |
OMAi | FQYEIYL |
OrthoDBi | 879633at2759 |
TreeFami | TF313363 |
Enzyme and pathway databases
UniPathwayi | UPA00199 |
Reactomei | R-BTA-390918, Peroxisomal lipid metabolism |
Gene expression databases
Bgeei | ENSBTAG00000000123, Expressed in kidney and 30 other tissues |
Family and domain databases
CDDi | cd02809, alpha_hydroxyacid_oxid_FMN, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR012133, Alpha-hydoxy_acid_DH_FMN IPR000262, FMN-dep_DH IPR037396, FMN_HAD IPR008259, FMN_hydac_DH_AS |
Pfami | View protein in Pfam PF01070, FMN_dh, 1 hit |
PIRSFi | PIRSF000138, Al-hdrx_acd_dh, 1 hit |
PROSITEi | View protein in PROSITE PS00557, FMN_HYDROXY_ACID_DH_1, 1 hit PS51349, FMN_HYDROXY_ACID_DH_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HAOX2_BOVIN | |
Accessioni | Q3ZBW2Primary (citable) accession number: Q3ZBW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | September 27, 2005 | |
Last modified: | February 23, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families