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Protein

F-box only protein 9

Gene

FBXO9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-BTA-8951664 Neddylation
R-BTA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 9
Gene namesi
Name:FBXO9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Organism-specific databases

VGNCiVGNC:28921 FBXO9

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002599561 – 437F-box only protein 9Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3ZBT2
PRIDEiQ3ZBT2

Expressioni

Gene expression databases

BgeeiENSBTAG00000015083 Expressed in 10 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020074

Structurei

3D structure databases

SMRiQ3ZBT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati84 – 117TPRAdd BLAST34
Domaini175 – 226F-boxPROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

TPR repeat

Phylogenomic databases

eggNOGiKOG2997 Eukaryota
ENOG410XPVI LUCA
GeneTreeiENSGT00390000014256
HOGENOMiHOG000047162
HOVERGENiHBG001041
InParanoidiQ3ZBT2
KOiK10295
OMAiSKTTYLR
OrthoDBiEOG091G0BDF
TreeFamiTF324797

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR036181 MIT_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ZBT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAEEDCHS EAVREGDDDD ENESPAETDL QAQLQRFRAQ WMFELAPGGG
60 70 80 90 100
SGNLESRPCR AARGSLLRAA DTRGKQELAK EEKARELFLK AVEEEQNGAL
110 120 130 140 150
YEAIKFYRRA MQLVPDIEFK ITYTRSPDGD GVGNSYIEDT DDDSKMADLL
160 170 180 190 200
SYFQQQLTFQ ESVLKLCQPE LESSQTHISA LPMEVLMYVF RWVVSSDLDL
210 220 230 240 250
RSLEQLSQVC RGFYICARDP EIWRLACLKV WGRSCIKLVP YTSWREMFLE
260 270 280 290 300
RPRVRFDGVY ISKTTYIRQG EQSLDGFYRA WHQVEYYRYV RFFPDGHVMM
310 320 330 340 350
LTTPEEPQSI VPRLRTRNTR TDAILLGHYR LSQDTDNQTK VFAVITKKKE
360 370 380 390 400
EKALDHKYRY FRRAPVQEAD QNFHVGLQLC SSGHQSFNKL IWIHHSCHIT
410 420 430
YKSTGETAVT AFEIDKMYTP LLFARVRSYT AFSERPL
Length:437
Mass (Da):50,817
Last modified:March 6, 2013 - v2
Checksum:iC4D85EB424BC0661
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189V → I in AAI03125 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02055275 Genomic DNA No translation available.
BC103124 mRNA Translation: AAI03125.1
RefSeqiNP_001029584.1, NM_001034412.2
UniGeneiBt.49317

Genome annotation databases

EnsembliENSBTAT00000020074; ENSBTAP00000020074; ENSBTAG00000015083
GeneIDi511798
KEGGibta:511798

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02055275 Genomic DNA No translation available.
BC103124 mRNA Translation: AAI03125.1
RefSeqiNP_001029584.1, NM_001034412.2
UniGeneiBt.49317

3D structure databases

SMRiQ3ZBT2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020074

Proteomic databases

PaxDbiQ3ZBT2
PRIDEiQ3ZBT2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020074; ENSBTAP00000020074; ENSBTAG00000015083
GeneIDi511798
KEGGibta:511798

Organism-specific databases

CTDi26268
VGNCiVGNC:28921 FBXO9

Phylogenomic databases

eggNOGiKOG2997 Eukaryota
ENOG410XPVI LUCA
GeneTreeiENSGT00390000014256
HOGENOMiHOG000047162
HOVERGENiHBG001041
InParanoidiQ3ZBT2
KOiK10295
OMAiSKTTYLR
OrthoDBiEOG091G0BDF
TreeFamiTF324797

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-BTA-8951664 Neddylation
R-BTA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSBTAG00000015083 Expressed in 10 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR036181 MIT_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX9_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBT2
Secondary accession number(s): F1MVQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: March 6, 2013
Last modified: September 12, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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