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Protein

Protein BEX3

Gene

BEX3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity).By similarity

Miscellaneous

Binds transition metals.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-BTA-205025 NADE modulates death signalling

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX3Curated
Alternative name(s):
Brain-expressed X-linked protein 3 homologBy similarity
Nerve growth factor receptor-associated protein 1
p75NTR-associated cell death executor
Gene namesi
Name:BEX3By similarity
Synonyms:NADE, NGFRAP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:50552 BEX3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297801 – 112Protein BEX3Add BLAST112

Post-translational modificationi

Ubiquitinated. Degraded by the proteasome (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ3ZBJ6
PRIDEiQ3ZBJ6

Expressioni

Gene expression databases

BgeeiENSBTAG00000006026 Expressed in 10 organ(s), highest expression level in brain

Interactioni

Subunit structurei

Self-associates. Binds to the DEATH domain of p75NTR/NGFR. Interacts with 14-3-3 epsilon YWHAE. Interacts with DIABLO/SMAC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007916

Structurei

3D structure databases

SMRiQ3ZBJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 112Interaction with 14-3-3 epsilonBy similarityAdd BLAST44
Regioni69 – 94Interaction with p75NTR/NGFRBy similarityAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi78 – 88Nuclear export signalBy similarityAdd BLAST11

Domaini

The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR.By similarity

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JCIT Eukaryota
ENOG41113TP LUCA
GeneTreeiENSGT00810000125492
HOGENOMiHOG000236300
HOVERGENiHBG080240
InParanoidiQ3ZBJ6
KOiK12465
OMAiLIMANIH
OrthoDBiEOG091G146U
TreeFamiTF337909

Family and domain databases

InterProiView protein in InterPro
IPR007623 BEX
IPR021156 TF_A-like/BEX
PfamiView protein in Pfam
PF04538 BEX, 1 hit
PIRSFiPIRSF008633 BEX, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ZBJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANIHQENEE MEQPVQNGEE DRPLGGGEGH QPERNHRRGQ ARRLAPNFRW
60 70 80 90 100
VIPNRQVNDG MGGEGDDMEI FMEEMREIRR KLRELQLRNC LRILMGELSN
110
HHDHHDEFCL MP
Length:112
Mass (Da):13,249
Last modified:September 27, 2005 - v1
Checksum:iF8B81AC939E90A7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103258 mRNA Translation: AAI03259.1
RefSeqiNP_001157249.1, NM_001163777.2
UniGeneiBt.49620

Genome annotation databases

EnsembliENSBTAT00000007916; ENSBTAP00000007916; ENSBTAG00000006026
GeneIDi100034674
KEGGibta:100034674

Similar proteinsi

Entry informationi

Entry nameiBEX3_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 27, 2005
Last modified: September 12, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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