UniProtKB - Q3ZBA6 (DJB11_BOVIN)
Protein
DnaJ homolog subfamily B member 11
Gene
DNAJB11
Organism
Bos taurus (Bovine)
Status
Functioni
As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.By similarity
GO - Molecular functioni
- signaling receptor binding Source: Ensembl
- unfolded protein binding Source: Ensembl
GO - Biological processi
- mRNA modification Source: Ensembl
- negative regulation of neurogenesis Source: Ensembl
- protein folding Source: InterPro
- protein maturation Source: UniProtKB
Keywordsi
Molecular function | Chaperone |
Names & Taxonomyi
Protein namesi | Recommended name: DnaJ homolog subfamily B member 11Alternative name(s): ER-associated DNAJ ER-associated Hsp40 co-chaperone Endoplasmic reticulum DNA J domain-containing protein 3 Short name: ER-resident protein ERdj3 Short name: ERdj3 Short name: ERj3p |
Gene namesi | Name:DNAJB11 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen By similarity
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: Ensembl
Nucleus
- nucleus Source: Ensembl
Keywords - Cellular componenti
Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | By similarityAdd BLAST | 22 | |
ChainiPRO_0000284954 | 23 – 358 | DnaJ homolog subfamily B member 11Add BLAST | 336 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 188 | PhosphothreonineBy similarity | 1 | |
Glycosylationi | 261 | N-linked (GlcNAc...) asparagineCurated | 1 |
Post-translational modificationi
Contains high-mannose Endo H-sensitive carbohydrates.By similarity
Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys is not known (By similarity).By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q3ZBA6 |
PeptideAtlasi | Q3ZBA6 |
PRIDEi | Q3ZBA6 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000003151, Expressed in spermatocyte and 19 other tissues |
Interactioni
Subunit structurei
Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Binds to denatured substrates in an ATP-independent manner.
Interacts via the J domain with HSPA5 in an ATP-dependent manner (By similarity).
By similarityGO - Molecular functioni
- signaling receptor binding Source: Ensembl
- unfolded protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000004094 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 90 | JPROSITE-ProRule annotationAdd BLAST | 66 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG0713, Eukaryota |
GeneTreei | ENSGT00940000155792 |
HOGENOMi | CLU_017633_0_0_1 |
InParanoidi | Q3ZBA6 |
OMAi | KEGMMDH |
OrthoDBi | 687505at2759 |
TreeFami | TF105144 |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR002939, DnaJ_C IPR001623, DnaJ_domain IPR018253, DnaJ_domain_CS IPR008971, HSP40/DnaJ_pept-bd IPR036869, J_dom_sf |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit PF01556, DnaJ_C, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit SSF49493, SSF49493, 2 hits |
PROSITEi | View protein in PROSITE PS00636, DNAJ_1, 1 hit PS50076, DNAJ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q3ZBA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPQNLGTFC LLLLYLIGTV IAGRDFYKIL GVPRSASIKD IKKAYRKLAL
60 70 80 90 100
QLHPDRNPDD PRAQEKFQDL GAAYEVLSDS EKRKQYDTYG EEGLKDGHQS
110 120 130 140 150
SHGDIFSHFF GDFGFMFGGT PRQQDRNIPR GSDIIVDLEV TLEEVYAGNF
160 170 180 190 200
VEVVRNKPVA RQAPGKRKCN CRQEMRTTQL GPGRFQMTQE VVCDECPNVK
210 220 230 240 250
LVNEERTLEV EIEPGVRDGM EYPFIGEGEP HVDGEPGDLR FRIKVVKHSI
260 270 280 290 300
FERRGDDLYT NVTISLVESL VGFDMDITHL DGHKVHISRD KITRPGAKLW
310 320 330 340 350
KKGEGLPNFD NNNIKGSLII TFDVDFPKEQ LSEEAREGIK QLLKQGSVQK
VYNGLQGY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC103470 mRNA Translation: AAI03471.1 |
RefSeqi | NP_001029440.1, NM_001034268.1 XP_005201525.1, XM_005201468.2 |
Genome annotation databases
Ensembli | ENSBTAT00000004094; ENSBTAP00000004094; ENSBTAG00000003151 |
GeneIDi | 506316 |
KEGGi | bta:506316 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC103470 mRNA Translation: AAI03471.1 |
RefSeqi | NP_001029440.1, NM_001034268.1 XP_005201525.1, XM_005201468.2 |
3D structure databases
SMRi | Q3ZBA6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000004094 |
Proteomic databases
PaxDbi | Q3ZBA6 |
PeptideAtlasi | Q3ZBA6 |
PRIDEi | Q3ZBA6 |
Genome annotation databases
Ensembli | ENSBTAT00000004094; ENSBTAP00000004094; ENSBTAG00000003151 |
GeneIDi | 506316 |
KEGGi | bta:506316 |
Organism-specific databases
CTDi | 51726 |
Phylogenomic databases
eggNOGi | KOG0713, Eukaryota |
GeneTreei | ENSGT00940000155792 |
HOGENOMi | CLU_017633_0_0_1 |
InParanoidi | Q3ZBA6 |
OMAi | KEGMMDH |
OrthoDBi | 687505at2759 |
TreeFami | TF105144 |
Gene expression databases
Bgeei | ENSBTAG00000003151, Expressed in spermatocyte and 19 other tissues |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR002939, DnaJ_C IPR001623, DnaJ_domain IPR018253, DnaJ_domain_CS IPR008971, HSP40/DnaJ_pept-bd IPR036869, J_dom_sf |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit PF01556, DnaJ_C, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit SSF49493, SSF49493, 2 hits |
PROSITEi | View protein in PROSITE PS00636, DNAJ_1, 1 hit PS50076, DNAJ_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DJB11_BOVIN | |
Accessioni | Q3ZBA6Primary (citable) accession number: Q3ZBA6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | September 27, 2005 | |
Last modified: | December 2, 2020 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |