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Entry version 98 (02 Jun 2021)
Sequence version 1 (27 Sep 2005)
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Protein

Tectonin beta-propeller repeat-containing protein 1

Gene

Tecpr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy
LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tectonin beta-propeller repeat-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tecpr1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Rat genome database

More...
RGDi
1306873, Tecpr1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003370631 – 1166Tectonin beta-propeller repeat-containing protein 1Add BLAST1166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei386PhosphoserineBy similarity1
Modified residuei388PhosphoserineBy similarity1
Modified residuei391PhosphoserineBy similarity1
Modified residuei413PhosphoserineBy similarity1
Modified residuei418PhosphoserineBy similarity1
Modified residuei943PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3ZBA0

PRoteomics IDEntifications database

More...
PRIDEi
Q3ZBA0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3ZBA0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3ZBA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001010, Expressed in frontal cortex and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3ZBA0, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATG5; the interaction is direct.

Interacts with WIPI2.

Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000001347

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3ZBA0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati209 – 240TECPR 1Add BLAST32
Repeati254 – 285TECPR 2Add BLAST32
Repeati301 – 332TECPR 3Add BLAST32
Repeati344 – 376TECPR 4Add BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini616 – 722PHAdd BLAST107
Repeati734 – 761TECPR 5Add BLAST28
Repeati958 – 989TECPR 6Add BLAST32
Repeati1003 – 1034TECPR 7Add BLAST32
Repeati1049 – 1080TECPR 8Add BLAST32
Repeati1092 – 1132TECPR 9Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni403 – 492DisorderedSequence analysisAdd BLAST90
Regioni1147 – 1166DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi420 – 435Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns3P).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TECPR1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3669, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047886

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008303_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3ZBA0

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAWQWDG

Database of Orthologous Groups

More...
OrthoDBi
119234at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3ZBA0

TreeFam database of animal gene trees

More...
TreeFami
TF323648

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006624, Beta-propeller_rpt_TECPR
IPR010482, Peroxin
IPR006614, Peroxin/Ferlin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06398, Pex24p, 2 hits
PF19193, Tectonin, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00694, DysFC, 2 hits
SM00693, DysFN, 2 hits
SM00706, TECPR, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3ZBA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTSMLWAVD LFGRVYTLST AGQYWELCKD VQLEFKRVSA ATQCCWGIAC
60 70 80 90 100
DNQVYLYVCS SDVPIRHREE AYENQRWNPM GGFCEKLLPS DRWSWSDVSG
110 120 130 140 150
LQHRPLDGVA LPSPYWEWES DWYVDENFGG EPTEKGGWTY AMDFPATYTR
160 170 180 190 200
DKKWNSCVRR RKWIRYRRYK SRDTWAKIPS KDDPKELPDP FNDLSVGGWE
210 220 230 240 250
ITEEPVGRLS VWAVSLQGKV WYRENVSHPN PEGSSWSLVD TPGEVVQISC
260 270 280 290 300
GPHDLIWATL WEGQALVREG ICRNNPKGNS WSIVEPPGSE NGIMHVSAGV
310 320 330 340 350
SVVWAITKDR KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GLNDQVWGIS
360 370 380 390 400
CEDRAVYFRQ GVTPSELSGK TWKAIVVGRE SDRSHSGSSS SLLSAGCFFG
410 420 430 440 450
EEVRGSGTES APSDTDASSE VERQGPERSL PKESLDNSRN LKGSSSKGHE
460 470 480 490 500
STRNTEDPME NACLAEGQAK APKTSGPDEC HGPAPTPAEL PWTNIDLKEP
510 520 530 540 550
KKASNQPAAG FPETSGLSSL GLFPMGMEEP YGADDHPLWA WVSGGGCAVE
560 570 580 590 600
AGSALKWFTV QSGLSPSVQT LSLSITPAQT AAWRKQIFQQ LTERTKRELE
610 620 630 640 650
SFRHYEQAVE QSVWVKTGAL QWWCDWKPHK WVDVRVALEQ FTGHDGARDS
660 670 680 690 700
ILFIYYVVHE EKKYLHVFLN EVTVLVPVLN EAKHSFALYT PERTRQRWPV
710 720 730 740 750
RLAATTEQDM NDWLTLLSLS CCESRKVHGR PSLQAIWSVT CKGDIFVSEP
760 770 780 790 800
SPDLEAHEHL LPCDQMFWRQ MGGHLRIIEA NSRGVVWGIG YDHTAWVYTG
810 820 830 840 850
GYGGGCFQGL ASSTSNIYTQ SDVKSVYIYE NQRWNPVTGY TSRGLPTDRY
860 870 880 890 900
MWSDVTGLQE CTKAGTKPPS LQWTWVSDWY VDFSVLGGTD QEGWQYASDF
910 920 930 940 950
PASYHGYKTM KDFVRRRCWA RKCKLVTSGP WLEVAPIALS DVSIIPESAD
960 970 980 990 1000
ANGRGHNIAL WAVSDKGDVL CRLGVSELNP AGSSWLHVGT DQPFASVSIG
1010 1020 1030 1040 1050
ACYQVWAVAR DGSAFYRGSV SPSQPAGDCW YHIPSPPKQK LTQVSVGQTS
1060 1070 1080 1090 1100
VYALDENGNL WYRAGITPSY PQGSSWEHVS NNVRKVSVGP LDQVWVIANK
1110 1120 1130 1140 1150
VQGSHGLSRG TVCRRMGVQP REPKGQGWDY GIGGGWDHIS VRANATRAPR
1160
NMSRDQEAHG PGPVCC
Length:1,166
Mass (Da):130,187
Last modified:September 27, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7CB6872B2F93BBD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC103478 mRNA Translation: AAI03479.1

NCBI Reference Sequences

More...
RefSeqi
NP_001032268.1, NM_001037191.1
XP_017453805.1, XM_017598316.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000001347; ENSRNOP00000001347; ENSRNOG00000001010

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
304285

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:304285

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103478 mRNA Translation: AAI03479.1
RefSeqiNP_001032268.1, NM_001037191.1
XP_017453805.1, XM_017598316.1

3D structure databases

SMRiQ3ZBA0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001347

PTM databases

iPTMnetiQ3ZBA0
PhosphoSitePlusiQ3ZBA0

Proteomic databases

PaxDbiQ3ZBA0
PRIDEiQ3ZBA0

Genome annotation databases

EnsembliENSRNOT00000001347; ENSRNOP00000001347; ENSRNOG00000001010
GeneIDi304285
KEGGirno:304285

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25851
RGDi1306873, Tecpr1

Phylogenomic databases

eggNOGiKOG3669, Eukaryota
GeneTreeiENSGT00510000047886
HOGENOMiCLU_008303_0_0_1
InParanoidiQ3ZBA0
OMAiMAWQWDG
OrthoDBi119234at2759
PhylomeDBiQ3ZBA0
TreeFamiTF323648

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q3ZBA0

Gene expression databases

BgeeiENSRNOG00000001010, Expressed in frontal cortex and 21 other tissues
GenevisibleiQ3ZBA0, RN

Family and domain databases

InterProiView protein in InterPro
IPR006624, Beta-propeller_rpt_TECPR
IPR010482, Peroxin
IPR006614, Peroxin/Ferlin
PfamiView protein in Pfam
PF06398, Pex24p, 2 hits
PF19193, Tectonin, 3 hits
SMARTiView protein in SMART
SM00694, DysFC, 2 hits
SM00693, DysFN, 2 hits
SM00706, TECPR, 11 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCPR1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3ZBA0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 27, 2005
Last modified: June 2, 2021
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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