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UniProtKB - Q3ZB46 (Q3ZB46_MOUSE)
Protein
Gastrin/cholecystokinin type B receptor
Gene
Cckbr
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
ARBA annotationGO - Molecular functioni
- cholecystokinin receptor activity Source: Ensembl
- gastrin receptor activity Source: Ensembl
- peptide hormone binding Source: Ensembl
- type B gastrin/cholecystokinin receptor binding Source: Ensembl
GO - Biological processi
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Gastrin/cholecystokinin type B receptorARBA annotationAlternative name(s): Cholecystokinin-2 receptorARBA annotation |
Gene namesi | Name:CckbrImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:99479, Cckbr |
VEuPathDBi | HostDB:ENSMUSG00000030898 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 58 – 79 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 91 – 112 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 132 – 150 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 171 – 191 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 217 – 241 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 337 – 356 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 376 – 398 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, Lipoprotein, PalmitateARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000030898, Expressed in cingulate cortex and 107 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 71 – 396 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 326 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 257 – 276 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_6_3_1 |
OMAi | NTTAHKC |
OrthoDBi | 1042780at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR009126, Cholcskin_rcpt IPR000314, Gastrin_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01822, CCYSTOKININR PR00527, GASTRINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3ZB46-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLLKLNRSL QGPGPGSGSS LCRPGVSLLN SSSAGNLSCE TPRIRGTGTR
60 70 80 90 100
ELELTIRITL YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD
110 120 130 140 150
LLLAVACMPF TLLPNLMGTF IFGTVICKAV SYLMGVSVSV STLNLAAIAL
160 170 180 190 200
ERYSAICRPL QARVWQTRSH AARVILATWL LSGLLMVPYP VYTVVQPVGP
210 220 230 240 250
RILQCMHLWP SERVQQMWSV LLLILLFFIP GVVMAVAYGL ISRELYLGLR
260 270 280 290 300
FDGDNDSETQ SRVRNQGGLP GGAAAPGPVH QNGGCRHVTS LTGEDSDGCY
310 320 330 340 350
VQLPRSRLEM TTLTTPTTGP GPGPRPNQAK LLAKKRVVRM LLVIVLLFFV
360 370 380 390 400
CWLPVYSANT WRAFDGPGAR RALAGAPISF IHLLSYTSAC ANPLVYCFMH
410 420 430 440 450
RRFRQACLDT CARCCPRPPR ARPRPLPDED PPTPSIASLS RLSYTTISTL
GPG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC103531 mRNA Translation: AAI03532.1 BC103538 mRNA Translation: AAI03539.1 |
RefSeqi | NP_031653.1, NM_007627.5 |
Genome annotation databases
GeneIDi | 12426 |
KEGGi | mmu:12426 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC103531 mRNA Translation: AAI03532.1 BC103538 mRNA Translation: AAI03539.1 |
RefSeqi | NP_031653.1, NM_007627.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 11193, 363 antibodies from 37 providers |
DNASUi | 12426 |
Genome annotation databases
GeneIDi | 12426 |
KEGGi | mmu:12426 |
Organism-specific databases
CTDi | 887 |
MGIi | MGI:99479, Cckbr |
VEuPathDBi | HostDB:ENSMUSG00000030898 |
Phylogenomic databases
HOGENOMi | CLU_009579_6_3_1 |
OMAi | NTTAHKC |
OrthoDBi | 1042780at2759 |
Miscellaneous databases
BioGRID-ORCSi | 12426, 1 hit in 72 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030898, Expressed in cingulate cortex and 107 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR009126, Cholcskin_rcpt IPR000314, Gastrin_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01822, CCYSTOKININR PR00527, GASTRINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3ZB46_MOUSE | |
Accessioni | Q3ZB46Primary (citable) accession number: Q3ZB46 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 27, 2005 |
Last sequence update: | September 27, 2005 | |
Last modified: | May 25, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |