UniProtKB - Q3ZB23 (Q3ZB23_MOUSE)
Protein
Protein Wnt
Gene
Wnt4
Organism
Mus musculus (Mouse)
Status
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors.UniRule annotation
GO - Molecular functioni
- receptor ligand activity Source: Ensembl
GO - Biological processi
- adrenal gland development Source: Ensembl
- canonical Wnt signaling pathway Source: Ensembl
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- epithelial to mesenchymal transition Source: Ensembl
- female sex determination Source: Ensembl
- kidney development Source: Ensembl
- liver development Source: Ensembl
- male gonad development Source: Ensembl
- mammary gland epithelium development Source: Ensembl
- negative regulation of androgen biosynthetic process Source: Ensembl
- negative regulation of male gonad development Source: Ensembl
- negative regulation of testicular blood vessel morphogenesis Source: Ensembl
- negative regulation of testosterone biosynthetic process Source: Ensembl
- negative regulation of transcription, DNA-templated Source: Ensembl
- non-canonical Wnt signaling pathway via MAPK cascade Source: Ensembl
- paramesonephric duct development Source: Ensembl
- positive regulation of aldosterone biosynthetic process Source: Ensembl
- positive regulation of bone mineralization Source: Ensembl
- positive regulation of collagen biosynthetic process Source: Ensembl
- positive regulation of cortisol biosynthetic process Source: Ensembl
- positive regulation of dermatome development Source: Ensembl
- positive regulation of osteoblast differentiation Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
Keywordsi
Molecular function | Developmental proteinUniRule annotationARBA annotation |
Biological process | Wnt signaling pathwayUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein WntUniRule annotation |
Gene namesi | Name:Wnt4Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:98957, Wnt4 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular space Source: Ensembl
Other locations
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
Extracellular matrixARBA annotation, SecretedPTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, LipoproteinARBA annotationProteomic databases
MaxQBi | Q3ZB23 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000036856, Expressed in cornea and 355 other tissues |
ExpressionAtlasi | Q3ZB23, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalARBA annotationPhylogenomic databases
HOGENOMi | CLU_033039_1_0_1 |
OMAi | CWRAMPP |
OrthoDBi | 745245at2759 |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR009142, Wnt4 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01844, WNT4PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3ZB23-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPRSCLRSL RLLVFAVFSA AASNWLYLAK LSSVGSISEE ETCEKLKGLI
60 70 80 90 100
QRQVQMCKRN LEVMDSVRRG AQLAIEECQY QFRNRRWNCS TLDSLPVFGK
110 120 130 140 150
VVTQGTREAA FVYAISSAGV AFAVTRACSS GELEKCGCDR TVHGVSPQGF
160 170 180 190 200
QWSGCSDNIA YGVAFSQSFV DVRERSKGAS SSRALMNLHN NEAGRKAILT
210 220 230 240 250
HMRVECKCHG VSGSCEVKTC WRAVPPFRQV GHALKEKFDG ATEVEPRRVG
260 270 280 290 300
SSRALVPRNA QFKPHTDEDL VYLEPSPDFC EQDIRSGVLG TRGRTCNKTS
310 320 330 340 350
KAIDGCELLC CGRGFHTAQV ELAERCGCRF HWCCFVKCRQ CQRLVEMHTC
R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC101962 mRNA Translation: AAI01963.1 BC103560 mRNA Translation: AAI03561.1 BC103561 mRNA Translation: AAI03562.1 BC103562 mRNA Translation: AAI03563.1 |
RefSeqi | NP_033549.1, NM_009523.2 |
Genome annotation databases
GeneIDi | 22417 |
KEGGi | mmu:22417 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC101962 mRNA Translation: AAI01963.1 BC103560 mRNA Translation: AAI03561.1 BC103561 mRNA Translation: AAI03562.1 BC103562 mRNA Translation: AAI03563.1 |
RefSeqi | NP_033549.1, NM_009523.2 |
3D structure databases
SMRi | Q3ZB23 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q3ZB23 |
Protocols and materials databases
Antibodypediai | 2555, 468 antibodies |
Genome annotation databases
GeneIDi | 22417 |
KEGGi | mmu:22417 |
Organism-specific databases
CTDi | 54361 |
MGIi | MGI:98957, Wnt4 |
Phylogenomic databases
HOGENOMi | CLU_033039_1_0_1 |
OMAi | CWRAMPP |
OrthoDBi | 745245at2759 |
Miscellaneous databases
BioGRID-ORCSi | 22417, 2 hits in 18 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036856, Expressed in cornea and 355 other tissues |
ExpressionAtlasi | Q3ZB23, baseline and differential |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR009142, Wnt4 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01844, WNT4PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3ZB23_MOUSE | |
Accessioni | Q3ZB23Primary (citable) accession number: Q3ZB23 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 27, 2005 |
Last sequence update: | September 27, 2005 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |