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UniProtKB - Q3ZB20 (Q3ZB20_MOUSE)
Protein
Voltage-dependent calcium channel gamma-2 subunit
Gene
Cacng2
Organism
Mus musculus (Mouse)
Status
Functioni
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
UniRule annotationGO - Molecular functioni
- ionotropic glutamate receptor binding Source: Ensembl
- voltage-gated calcium channel activity Source: InterPro
GO - Biological processi
- eye blink reflex Source: Ensembl
- positive regulation of AMPA receptor activity Source: Ensembl
- positive regulation of protein localization to basolateral plasma membrane Source: Ensembl
- protein targeting to membrane Source: Ensembl
- response to calcium ion Source: Ensembl
Keywordsi
Molecular function | Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent calcium channel gamma-2 subunitUniRule annotation |
Gene namesi | Name:Cacng2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1316660, Cacng2 |
VEuPathDBi | HostDB:ENSMUSG00000019146 |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Cytosol
- cytosol Source: Ensembl
Plasma Membrane
- AMPA glutamate receptor complex Source: Ensembl
- postsynaptic density membrane Source: Ensembl
- voltage-gated calcium channel complex Source: InterPro
Other locations
- cell surface Source: Ensembl
- cerebellar mossy fiber Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 35 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 106 – 128 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 135 – 158 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 178 – 202 | HelicalUniRule annotationAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000019146, Expressed in lumbar subsegment of spinal cord and 171 other tissues |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 233 – 261 | DisorderedSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
HOGENOMi | CLU_053704_0_1_1 |
OMAi | CIQKESK |
OrthoDBi | 1117127at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR005422, VDCC_g2su IPR008368, VDCC_gsu |
PANTHERi | PTHR12107:SF1, PTHR12107:SF1, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01792, VDCCGAMMA PR01602, VDCCGAMMA2 |
i Sequence
Sequence statusi: Complete.
Q3ZB20-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLFDRGVQM LLTTVGAFAA FSLMTIAVGT DYWLYSRGVC KTKSVSENET
60 70 80 90 100
SKKNEEVMTH SGLWRTCCLE GNFKGLCKQI DHFPEDADYE ADTAEYFLRA
110 120 130 140 150
VRASSIFPIL SVILLFMGGL CIAASEFYKT RHNIILSAGI FFVSAGLSNI
160 170 180 190 200
IGIIVYISAN AGDPSKSDSK KNSYSYGWSF YFGALSFIIA EMVGVLAVHM
210 220 230 240 250
FIDRHKQLRA TARATDYLQA SAITRIPSYR YRYQRRSRSS SRSTEPSHSR
260 270 280 290 300
DASPVGVKGF NTLPSTEISM YTLSRDPLKA ATTPTATYNS DRDNSFLQVH
310 320
NCIQKDSKDS LHANTANRRT TPV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC103563 mRNA Translation: AAI03564.1 BC103564 mRNA Translation: AAI03565.1 BC103664 mRNA Translation: AAI03665.1 |
RefSeqi | NP_031609.1, NM_007583.2 |
Genome annotation databases
GeneIDi | 12300 |
KEGGi | mmu:12300 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC103563 mRNA Translation: AAI03564.1 BC103564 mRNA Translation: AAI03565.1 BC103664 mRNA Translation: AAI03665.1 |
RefSeqi | NP_031609.1, NM_007583.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 25748, 229 antibodies from 36 providers |
DNASUi | 12300 |
Genome annotation databases
GeneIDi | 12300 |
KEGGi | mmu:12300 |
Organism-specific databases
CTDi | 10369 |
MGIi | MGI:1316660, Cacng2 |
VEuPathDBi | HostDB:ENSMUSG00000019146 |
Phylogenomic databases
HOGENOMi | CLU_053704_0_1_1 |
OMAi | CIQKESK |
OrthoDBi | 1117127at2759 |
Miscellaneous databases
BioGRID-ORCSi | 12300, 1 hit in 63 CRISPR screens |
ChiTaRSi | Cacng2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019146, Expressed in lumbar subsegment of spinal cord and 171 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR005422, VDCC_g2su IPR008368, VDCC_gsu |
PANTHERi | PTHR12107:SF1, PTHR12107:SF1, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01792, VDCCGAMMA PR01602, VDCCGAMMA2 |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3ZB20_MOUSE | |
Accessioni | Q3ZB20Primary (citable) accession number: Q3ZB20 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 27, 2005 |
Last sequence update: | September 27, 2005 | |
Last modified: | January 19, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |