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Protein

Vacuolar ATPase assembly integral membrane protein VMA21

Gene

VMA21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.UniRule annotation1 Publication

Caution

Protein characterization data are from PubMed:19379691. Due to a number of errors in the figure panels, the article has been retracted but the authors stand by the validity of the main results and conclusions (PubMed:20873370).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • regulation of ATPase activity Source: ParkinsonsUK-UCL
  • vacuolar proton-transporting V-type ATPase complex assembly Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar ATPase assembly integral membrane protein VMA21UniRule annotation
Alternative name(s):
Myopathy with excessive autophagy protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VMA21UniRule annotation
Synonyms:MEAX, XMEA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160131.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22082 VMA21

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300913 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3ZAQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 25CytoplasmicUniRule annotationAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 46HelicalUniRule annotationAdd BLAST21
Topological domaini47 – 65LumenalUniRule annotationAdd BLAST19
Transmembranei66 – 86HelicalUniRule annotationAdd BLAST21
Topological domaini87 – 101CytoplasmicUniRule annotationAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopathy, X-linked, with excessive autophagy (MEAX)4 Publications
The disease is caused by mutations affecting the gene represented in this entry. VMA21 deficiency results in an increase of lysosomal pH from 4.7 to 5.2, which reduces lysosomal degradative ability and blocks autophagy. This reduces cellular free amino acids, which upregulates the mTOR pathway and mTOR-dependent macroautophagy, resulting in proliferation of large and ineffective autolysosomes that engulf sections of cytoplasm, merge together, and vacuolate the cell.1 Publication
Disease descriptionA muscle disorder characterized by childhood early onset of a slowly progressive proximal limb muscle weakness (especially in legs) and elevation of serum creatine kinase, without evidence of cardiac, respiratory or central nervous system involvement. Histopathological analysis reveals diseased muscle fibers that are not necrotic, but show abnormal autophagic vacuolation as a manifestation of excessive autophagic activity in skeletal muscle cells.
See also OMIM:310440

Organism-specific databases

DisGeNET

More...
DisGeNETi
203547

MalaCards human disease database

More...
MalaCardsi
VMA21
MIMi310440 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000160131

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
25980 X-linked myopathy with excessive autophagy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164727498

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VMA21

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121943063

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003314991 – 101Vacuolar ATPase assembly integral membrane protein VMA21Add BLAST101

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3ZAQ7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3ZAQ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3ZAQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3ZAQ7

PeptideAtlas

More...
PeptideAtlasi
Q3ZAQ7

PRoteomics IDEntifications database

More...
PRIDEi
Q3ZAQ7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61901
61902 [Q3ZAQ7-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q3ZAQ7-1 [Q3ZAQ7-1]
Q3ZAQ7-2 [Q3ZAQ7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3ZAQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3ZAQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160131 Expressed in 205 organ(s), highest expression level in female gonad

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3ZAQ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA010972

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the V0 complex of the vacuolar ATPase (V-ATPase).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128477, 35 interactors

Protein interaction database and analysis system

More...
IntActi
Q3ZAQ7, 35 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000333255

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q3ZAQ7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VMA21 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4783 Eukaryota
ENOG411241C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017980

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154822

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3ZAQ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRAYFGG

Database of Orthologous Groups

More...
OrthoDBi
1156337at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3ZAQ7

TreeFam database of animal gene trees

More...
TreeFami
TF314021

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03058 VMA21, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019013 Vma21

The PANTHER Classification System

More...
PANTHERi
PTHR31792 PTHR31792, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09446 VMA21, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3ZAQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERPDKAALN ALQPPEFRNE SSLASTLKTL LFFTALMITV PIGLYFTTKS
60 70 80 90 100
YIFEGALGMS NRDSYFYAAI VAVVAVHVVL ALFVYVAWNE GSRQWREGKQ

D
Length:101
Mass (Da):11,354
Last modified:September 27, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DE436A7FF533443
GO
Isoform 2 (identifier: Q3ZAQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MERPDKAALNALQPPEF → MLGSPCGPQL...LAGRTPRSHR

Note: No experimental confirmation available.
Show »
Length:156
Mass (Da):17,766
Checksum:i8A3F475CD071D5BC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0412571 – 17MERPD…QPPEF → MLGSPCGPQLSDRDADEDQC SREFRGRRSRRPPRRTMLRG KSRLNVEWLGYSPGLLLEHR PLLAGRTPRSHR in isoform 2. CuratedAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK096835 mRNA Translation: BAG53371.1
AF003627 Genomic DNA No translation available.
BC103701 mRNA Translation: AAI03702.1
BC103702 mRNA Translation: AAI03703.1
BC105693 mRNA Translation: AAI05694.1
BC105694 mRNA Translation: AAI05695.1
BC110800 mRNA Translation: AAI10801.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35430.1 [Q3ZAQ7-1]
CCDS87789.1 [Q3ZAQ7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001017980.1, NM_001017980.3 [Q3ZAQ7-1]
XP_011529427.1, XM_011531125.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.58633

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330374; ENSP00000333255; ENSG00000160131 [Q3ZAQ7-1]
ENST00000370361; ENSP00000359386; ENSG00000160131 [Q3ZAQ7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
203547

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:203547

UCSC genome browser

More...
UCSCi
uc004feu.4 human [Q3ZAQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096835 mRNA Translation: BAG53371.1
AF003627 Genomic DNA No translation available.
BC103701 mRNA Translation: AAI03702.1
BC103702 mRNA Translation: AAI03703.1
BC105693 mRNA Translation: AAI05694.1
BC105694 mRNA Translation: AAI05695.1
BC110800 mRNA Translation: AAI10801.1
CCDSiCCDS35430.1 [Q3ZAQ7-1]
CCDS87789.1 [Q3ZAQ7-2]
RefSeqiNP_001017980.1, NM_001017980.3 [Q3ZAQ7-1]
XP_011529427.1, XM_011531125.2
UniGeneiHs.58633

3D structure databases

ProteinModelPortaliQ3ZAQ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128477, 35 interactors
IntActiQ3ZAQ7, 35 interactors
STRINGi9606.ENSP00000333255

PTM databases

iPTMnetiQ3ZAQ7
PhosphoSitePlusiQ3ZAQ7

Polymorphism and mutation databases

BioMutaiVMA21
DMDMi121943063

Proteomic databases

EPDiQ3ZAQ7
jPOSTiQ3ZAQ7
MaxQBiQ3ZAQ7
PaxDbiQ3ZAQ7
PeptideAtlasiQ3ZAQ7
PRIDEiQ3ZAQ7
ProteomicsDBi61901
61902 [Q3ZAQ7-2]
TopDownProteomicsiQ3ZAQ7-1 [Q3ZAQ7-1]
Q3ZAQ7-2 [Q3ZAQ7-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
203547
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330374; ENSP00000333255; ENSG00000160131 [Q3ZAQ7-1]
ENST00000370361; ENSP00000359386; ENSG00000160131 [Q3ZAQ7-2]
GeneIDi203547
KEGGihsa:203547
UCSCiuc004feu.4 human [Q3ZAQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
203547
DisGeNETi203547
EuPathDBiHostDB:ENSG00000160131.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
VMA21
HGNCiHGNC:22082 VMA21
HPAiHPA010972
MalaCardsiVMA21
MIMi300913 gene
310440 phenotype
neXtProtiNX_Q3ZAQ7
OpenTargetsiENSG00000160131
Orphaneti25980 X-linked myopathy with excessive autophagy
PharmGKBiPA164727498

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4783 Eukaryota
ENOG411241C LUCA
GeneTreeiENSGT00390000017980
HOGENOMiHOG000154822
InParanoidiQ3ZAQ7
OMAiYRAYFGG
OrthoDBi1156337at2759
PhylomeDBiQ3ZAQ7
TreeFamiTF314021

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
VMA21 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
203547

Protein Ontology

More...
PROi
PR:Q3ZAQ7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160131 Expressed in 205 organ(s), highest expression level in female gonad
GenevisibleiQ3ZAQ7 HS

Family and domain databases

HAMAPiMF_03058 VMA21, 1 hit
InterProiView protein in InterPro
IPR019013 Vma21
PANTHERiPTHR31792 PTHR31792, 1 hit
PfamiView protein in Pfam
PF09446 VMA21, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVMA21_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3ZAQ7
Secondary accession number(s): A6NKV7, B3KUA9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 27, 2005
Last modified: January 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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