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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD-1), Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79Anthranilate 1; via carbonyl oxygenUniRule annotation1
Binding sitei79Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei87PhosphoribosylpyrophosphateUniRule annotation1
Metal bindingi91Magnesium 1UniRule annotation1
Binding sitei110Anthranilate 1UniRule annotation1
Binding sitei119Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei165Anthranilate 2UniRule annotation1
Metal bindingi224Magnesium 2UniRule annotation1
Metal bindingi225Magnesium 1UniRule annotation1
Metal bindingi225Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:DET1483
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
Proteomesi
  • UP000008289 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002271531 – 341Anthranilate phosphoribosyltransferaseAdd BLAST341

Proteomic databases

PRIDEiQ3Z6G6

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243164.DET1483

Structurei

3D structure databases

ProteinModelPortaliQ3Z6G6
SMRiQ3Z6G6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 83Phosphoribosylpyrophosphate bindingUniRule annotation2
Regioni89 – 92Phosphoribosylpyrophosphate bindingUniRule annotation4
Regioni107 – 115Phosphoribosylpyrophosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYG Bacteria
COG0547 LUCA
HOGENOMiHOG000230451
KOiK00766
OMAiLCALKIK
OrthoDBiPOG091H01QX

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
HAMAPiMF_00211 TrpD, 1 hit
InterProiView protein in InterPro
IPR005940 Anthranilate_Pribosyl_Tfrase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
TIGRFAMsiTIGR01245 trpD, 1 hit

Sequencei

Sequence statusi: Complete.

Q3Z6G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKEAIGSLV LGKSLTLEQS ASVMDEIMEG KTTPAQIGAF LTALRVKGET
60 70 80 90 100
AEEIAGLANV MRAKSTRIST STPVLDIVGI GGDGINTFNI STTAAFVISG
110 120 130 140 150
AGIKVAKHGN RAASSMCGSA DVLEALGIKI DLNAEQVKIC IEQIGIGFMF
160 170 180 190 200
APVFHPAMKF VAPSRREIGI RTVFNILGPL TNPASAQYQL IGVPEIGLGD
210 220 230 240 250
KIISALCHMD IKHALVVHGL DGMDEMSISG DSVIWELKDK EIIKFRHTVS
260 270 280 290 300
PREMGLEQVS LQAVKGGAAE ENALTLRAIL SGAKGPKRDV VLLNAAAALM
310 320 330 340
VADKIDTIAE GISLAAEIID NGLALNKLES LIKLSQSLAS G
Length:341
Mass (Da):35,748
Last modified:September 27, 2005 - v1
Checksum:i8445ACAFB3A7017C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA Translation: AAW39329.1
RefSeqiWP_010937160.1, NC_002936.3

Genome annotation databases

EnsemblBacteriaiAAW39329; AAW39329; DET1483
GeneIDi3229287
KEGGidet:DET1483

Similar proteinsi

Entry informationi

Entry nameiTRPD_DEHM1
AccessioniPrimary (citable) accession number: Q3Z6G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 27, 2005
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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