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Protein

ATP-dependent protease subunit HslV

Gene

hslV

Organism
Ehrlichia canis (strain Jake)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.UniRule annotation

Catalytic activityi

ATP-dependent cleavage of peptide bonds with broad specificity.UniRule annotation

Activity regulationi

Allosterically activated by HslU binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei12UniRule annotation1
Metal bindingi172Sodium; via carbonyl oxygenUniRule annotation1
Metal bindingi175Sodium; via carbonyl oxygenUniRule annotation1
Metal bindingi178Sodium; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Hydrolase, Protease, Threonine protease
LigandMetal-binding, Sodium

Enzyme and pathway databases

BioCyciECAN269484:ECAJ_RS04135-MONOMER

Protein family/group databases

MEROPSiT01.006

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease subunit HslVUniRule annotation (EC:3.4.25.2UniRule annotation)
Gene namesi
Name:hslVUniRule annotation
Ordered Locus Names:Ecaj_0804
OrganismiEhrlichia canis (strain Jake)
Taxonomic identifieri269484 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000000435 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000126081 – 189ATP-dependent protease subunit HslVAdd BLAST189

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Protein-protein interaction databases

STRINGi269484.Ecaj_0804

Structurei

3D structure databases

ProteinModelPortaliQ3YR20
SMRiQ3YR20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family. HslV subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108R5P Bacteria
COG5405 LUCA
HOGENOMiHOG000064533
KOiK01419
OMAiIMKGNAR
OrthoDBiPOG091H024X

Family and domain databases

CDDicd01913 protease_HslV, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00248 HslV, 1 hit
InterProiView protein in InterPro
IPR022281 ATP-dep_Prtase_HsIV_su
IPR029055 Ntn_hydrolases_N
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR32194 PTHR32194, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PIRSFiPIRSF039093 HslV, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03692 ATP_dep_HslV, 1 hit
PROSITEiView protein in PROSITE
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3YR20-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHKDPSQMY GTTILCIRRG NQVIIAGDGQ VSLGQTVIKN SAKKIKRLAN
60 70 80 90 100
DTVITGFAGA TADAFTLFER LESKLEKHPG QLLRACVELA KDWRMDKYLR
110 120 130 140 150
RLEAMMIVAD KSISLIISGN GDVLEPENGI AAIGSGGNYA LAAAKALCET
160 170 180
NERFSQNMTL EYTITTAMRI ASEICIYTNN NIIIEKIED
Length:189
Mass (Da):20,759
Last modified:September 27, 2005 - v1
Checksum:i7F049B3B9E67A95F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000107 Genomic DNA Translation: AAZ68835.1
RefSeqiWP_011304912.1, NC_007354.1

Genome annotation databases

EnsemblBacteriaiAAZ68835; AAZ68835; Ecaj_0804
KEGGiecn:Ecaj_0804

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000107 Genomic DNA Translation: AAZ68835.1
RefSeqiWP_011304912.1, NC_007354.1

3D structure databases

ProteinModelPortaliQ3YR20
SMRiQ3YR20
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269484.Ecaj_0804

Protein family/group databases

MEROPSiT01.006

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ68835; AAZ68835; Ecaj_0804
KEGGiecn:Ecaj_0804

Phylogenomic databases

eggNOGiENOG4108R5P Bacteria
COG5405 LUCA
HOGENOMiHOG000064533
KOiK01419
OMAiIMKGNAR
OrthoDBiPOG091H024X

Enzyme and pathway databases

BioCyciECAN269484:ECAJ_RS04135-MONOMER

Family and domain databases

CDDicd01913 protease_HslV, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00248 HslV, 1 hit
InterProiView protein in InterPro
IPR022281 ATP-dep_Prtase_HsIV_su
IPR029055 Ntn_hydrolases_N
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR32194 PTHR32194, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PIRSFiPIRSF039093 HslV, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03692 ATP_dep_HslV, 1 hit
PROSITEiView protein in PROSITE
PS51476 PROTEASOME_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSLV_EHRCJ
AccessioniPrimary (citable) accession number: Q3YR20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 27, 2005
Last modified: October 10, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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