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Protein

Rab-like protein 6

Gene

RABL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 57GTPSequence analysis8
Nucleotide bindingi100 – 104GTPSequence analysis5
Nucleotide bindingi177 – 179GTPSequence analysis3

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: MGI

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-like protein 6
Alternative name(s):
GTP-binding protein Parf
Partner of ARF
Rab-like protein 1
Short name:
RBEL1
Gene namesi
Name:RABL6
Synonyms:C9orf86, PARF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000196642.16
HGNCiHGNC:24703 RABL6
MIMi610615 gene
neXtProtiNX_Q3YEC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55684
OpenTargetsiENSG00000196642
PharmGKBiPA134868176

Polymorphism and mutation databases

BioMutaiRABL6
DMDMi125957950

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002742231 – 729Rab-like protein 6Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei402PhosphoserineCombined sources1
Modified residuei425PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1
Modified residuei470PhosphoserineBy similarity1
Modified residuei471PhosphoserineBy similarity1
Modified residuei492PhosphoserineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei599PhosphothreonineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1

Post-translational modificationi

Isoform 1 is O-glycosylated, while other isoforms are not.1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ3YEC7
MaxQBiQ3YEC7
PaxDbiQ3YEC7
PeptideAtlasiQ3YEC7
PRIDEiQ3YEC7
ProteomicsDBi61895
61896 [Q3YEC7-2]
61897 [Q3YEC7-3]
61898 [Q3YEC7-4]
61899 [Q3YEC7-5]
61900 [Q3YEC7-6]

PTM databases

iPTMnetiQ3YEC7
PhosphoSitePlusiQ3YEC7

Expressioni

Gene expression databases

BgeeiENSG00000196642 Expressed in 127 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ3YEC7 baseline and differential
GenevisibleiQ3YEC7 HS

Organism-specific databases

HPAiHPA044037

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120812, 50 interactors
IntActiQ3YEC7, 23 interactors
STRINGi9606.ENSP00000360727

Structurei

3D structure databases

ProteinModelPortaliQ3YEC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 279Small GTPase-likeAdd BLAST241
Regioni655 – 693Interaction with CDKN2A1 PublicationAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi293 – 384Pro-richAdd BLAST92
Compositional biasi645 – 685Lys-richAdd BLAST41

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084 Eukaryota
ENOG410XQN5 LUCA
GeneTreeiENSGT00390000016002
HOGENOMiHOG000015428
HOVERGENiHBG080325
InParanoidiQ3YEC7
OMAiSKWRQSP
OrthoDBiEOG091G05OK
PhylomeDBiQ3YEC7
TreeFamiTF313974

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3YEC7-1) [UniParc]FASTAAdd to basket
Also known as: RBEL1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG
60 70 80 90 100
DRNTGKTALW HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD
110 120 130 140 150
VVDKGKCKKR GDGLKMENDP QEAESEMALD AEFLDVYKNC NGVVMMFDIT
160 170 180 190 200
KQWTFNYILR ELPKVPTHVP VCVLGNYRDM GEHRVILPDD VRDFIDNLDR
210 220 230 240 250
PPGSSYFRYA ESSMKNSFGL KYLHKFFNIP FLQLQRETLL RQLETNQLDM
260 270 280 290 300
DATLEELSVQ QETEDQNYGI FLEMMEARSR GHASPLAANG QSPSPGSQSP
310 320 330 340 350
VVPAGAVSTG SSSPGTPQPA PQLPLNAAPP SSVPPVPPSE ALPPPACPSA
360 370 380 390 400
PAPRRSIISR LFGTSPATEA APPPPEPVPA AEGPATVQSV EDFVPDDRLD
410 420 430 440 450
RSFLEDTTPA RDEKKVGAKA AQQDSDSDGE ALGGNPMVAG FQDDVDLEDQ
460 470 480 490 500
PRGSPPLPAG PVPSQDITLS SEEEAEVAAP TKGPAPAPQQ CSEPETKWSS
510 520 530 540 550
IPASKPRRGT APTRTAAPPW PGGVSVRTGP EKRSSTRPPA EMEPGKGEQA
560 570 580 590 600
SSSESDPEGP IAAQMLSFVM DDPDFESEGS DTQRRADDFP VRDDPSDVTD
610 620 630 640 650
EDEGPAEPPP PPKLPLPAFR LKNDSDLFGL GLEEAGPKES SEEGKEGKTP
660 670 680 690 700
SKEKKKKKKK GKEEEEKAAK KKSKHKKSKD KEEGKEERRR RQQRPPRSRE
710 720
RTAADELEAF LGGGAPGGRH PGGGDYEEL
Note: Predominant isoform. Overexpressed in about 67% of primary breast tumors.
Length:729
Mass (Da):79,549
Last modified:February 6, 2007 - v2
Checksum:i6C3FDB38C7FD7D59
GO
Isoform 2 (identifier: Q3YEC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     199-199: D → DS

Show »
Length:730
Mass (Da):79,636
Checksum:i76CED43E38D6167F
GO
Isoform 3 (identifier: Q3YEC7-3) [UniParc]FASTAAdd to basket
Also known as: RBEL1B

The sequence of this isoform differs from the canonical sequence as follows:
     361-729: LFGTSPATEA...HPGGGDYEEL → PPPWGWRLRG...AYGSASGREP

Note: No experimental confirmation available.
Show »
Length:520
Mass (Da):57,397
Checksum:iABB2BD2287F358BF
GO
Isoform 4 (identifier: Q3YEC7-4) [UniParc]FASTAAdd to basket
Also known as: RBEL1D

The sequence of this isoform differs from the canonical sequence as follows:
     236-264: RETLLRQLETNQLDMDATLEELSVQQETE → VSTHHVGWSGCWSLTSFQVSPV
     265-729: Missing.

Show »
Length:257
Mass (Da):29,585
Checksum:iB086094A0AA8FCB0
GO
Isoform 5 (identifier: Q3YEC7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     199-199: D → DS
     236-264: RETLLRQLETNQLDMDATLEELSVQQETE → VSTHHVGWSGCWSLTSFQVSPV
     265-729: Missing.

Show »
Length:258
Mass (Da):29,672
Checksum:i99980CF4224BDA2F
GO
Isoform 6 (identifier: Q3YEC7-6) [UniParc]FASTAAdd to basket
Also known as: RBEL1C

The sequence of this isoform differs from the canonical sequence as follows:
     236-302: RETLLRQLET...PSPGSQSPVV → KDVRLAQERG...SSPLLSCSIP
     303-729: Missing.

Show »
Length:314
Mass (Da):35,809
Checksum:i64FCC800FAB9C14E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4Z8H0Y4Z8_HUMAN
Chromosome 9 open reading frame 86,...
RABL6 C9orf86, hCG_2021977
730Annotation score:
G3V154G3V154_HUMAN
Chromosome 9 open reading frame 86,...
RABL6 C9orf86, hCG_2021977
471Annotation score:
F2Z2T0F2Z2T0_HUMAN
Rab-like protein 6
RABL6
484Annotation score:
H0Y7H6H0Y7H6_HUMAN
Rab-like protein 6
RABL6
215Annotation score:

Sequence cautioni

The sequence AAH02945 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH21095 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH35786 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14408 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55213 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137Y → C in BAB14408 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030210382E → Q4 PublicationsCorresponds to variant dbSNP:rs2811741Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022646199D → DS in isoform 2 and isoform 5. 2 Publications1
Alternative sequenceiVSP_042559236 – 302RETLL…QSPVV → KDVRLAQERGCAVVLVSEEV RMPAGWDCCWGRLGWKEGGS QTCPVPALLGRPLLPAEPSP HHWVDYSLESSPLLSCSIP in isoform 6. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_022647236 – 264RETLL…QQETE → VSTHHVGWSGCWSLTSFQVS PV in isoform 4 and isoform 5. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_022648265 – 729Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST465
Alternative sequenceiVSP_042560303 – 729Missing in isoform 6. 1 PublicationAdd BLAST427
Alternative sequenceiVSP_022649361 – 729LFGTS…DYEEL → PPPWGWRLRGALGRRGQWPP WGGGRACHCLGRHLPLYHRL CRCPVAAVCASELEEAGHWW SPGWALQVLGLQAQCEPALQ EGRGQLASARLGGHPGPLGA EPPVFLRDVTEAQEGPVRVC LQRLGRGRLAVGCALPRHLL ALRAHLGPQHAYGSASGREP in isoform 3. 2 PublicationsAdd BLAST369

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ141240 mRNA Translation: AAZ73768.1
EF156752 mRNA Translation: ABO84837.1
EF156753 mRNA Translation: ABO84838.1
GQ169126 mRNA Translation: ACS45171.1
GQ169127 mRNA Translation: ACS45172.1
AL355987 Genomic DNA No translation available.
DQ099383 mRNA Translation: AAZ13759.1
BC002945 mRNA Translation: AAH02945.2 Different initiation.
BC021095 mRNA Translation: AAH21095.2 Different initiation.
BC035786 mRNA Translation: AAH35786.1 Different initiation.
AK023107 mRNA Translation: BAB14408.1 Different initiation.
AK027586 mRNA Translation: BAB55213.1 Different initiation.
AL713707 mRNA Translation: CAD28504.1
CCDSiCCDS48058.1 [Q3YEC7-1]
CCDS55352.1 [Q3YEC7-2]
CCDS55353.1 [Q3YEC7-6]
RefSeqiNP_001167459.1, NM_001173988.1 [Q3YEC7-2]
NP_001167460.1, NM_001173989.2 [Q3YEC7-6]
NP_078994.3, NM_024718.4 [Q3YEC7-1]
UniGeneiHs.370555

Genome annotation databases

EnsembliENST00000311502; ENSP00000311134; ENSG00000196642 [Q3YEC7-1]
ENST00000357466; ENSP00000350056; ENSG00000196642 [Q3YEC7-3]
ENST00000371663; ENSP00000360727; ENSG00000196642 [Q3YEC7-2]
ENST00000371671; ENSP00000360736; ENSG00000196642 [Q3YEC7-6]
GeneIDi55684
KEGGihsa:55684
UCSCiuc004cjh.4 human [Q3YEC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ141240 mRNA Translation: AAZ73768.1
EF156752 mRNA Translation: ABO84837.1
EF156753 mRNA Translation: ABO84838.1
GQ169126 mRNA Translation: ACS45171.1
GQ169127 mRNA Translation: ACS45172.1
AL355987 Genomic DNA No translation available.
DQ099383 mRNA Translation: AAZ13759.1
BC002945 mRNA Translation: AAH02945.2 Different initiation.
BC021095 mRNA Translation: AAH21095.2 Different initiation.
BC035786 mRNA Translation: AAH35786.1 Different initiation.
AK023107 mRNA Translation: BAB14408.1 Different initiation.
AK027586 mRNA Translation: BAB55213.1 Different initiation.
AL713707 mRNA Translation: CAD28504.1
CCDSiCCDS48058.1 [Q3YEC7-1]
CCDS55352.1 [Q3YEC7-2]
CCDS55353.1 [Q3YEC7-6]
RefSeqiNP_001167459.1, NM_001173988.1 [Q3YEC7-2]
NP_001167460.1, NM_001173989.2 [Q3YEC7-6]
NP_078994.3, NM_024718.4 [Q3YEC7-1]
UniGeneiHs.370555

3D structure databases

ProteinModelPortaliQ3YEC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120812, 50 interactors
IntActiQ3YEC7, 23 interactors
STRINGi9606.ENSP00000360727

PTM databases

iPTMnetiQ3YEC7
PhosphoSitePlusiQ3YEC7

Polymorphism and mutation databases

BioMutaiRABL6
DMDMi125957950

Proteomic databases

EPDiQ3YEC7
MaxQBiQ3YEC7
PaxDbiQ3YEC7
PeptideAtlasiQ3YEC7
PRIDEiQ3YEC7
ProteomicsDBi61895
61896 [Q3YEC7-2]
61897 [Q3YEC7-3]
61898 [Q3YEC7-4]
61899 [Q3YEC7-5]
61900 [Q3YEC7-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311502; ENSP00000311134; ENSG00000196642 [Q3YEC7-1]
ENST00000357466; ENSP00000350056; ENSG00000196642 [Q3YEC7-3]
ENST00000371663; ENSP00000360727; ENSG00000196642 [Q3YEC7-2]
ENST00000371671; ENSP00000360736; ENSG00000196642 [Q3YEC7-6]
GeneIDi55684
KEGGihsa:55684
UCSCiuc004cjh.4 human [Q3YEC7-1]

Organism-specific databases

CTDi55684
DisGeNETi55684
EuPathDBiHostDB:ENSG00000196642.16
GeneCardsiRABL6
HGNCiHGNC:24703 RABL6
HPAiHPA044037
MIMi610615 gene
neXtProtiNX_Q3YEC7
OpenTargetsiENSG00000196642
PharmGKBiPA134868176
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0084 Eukaryota
ENOG410XQN5 LUCA
GeneTreeiENSGT00390000016002
HOGENOMiHOG000015428
HOVERGENiHBG080325
InParanoidiQ3YEC7
OMAiSKWRQSP
OrthoDBiEOG091G05OK
PhylomeDBiQ3YEC7
TreeFamiTF313974

Miscellaneous databases

ChiTaRSiRABL6 human
GeneWikiiC9orf86
GenomeRNAii55684
PROiPR:Q3YEC7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196642 Expressed in 127 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ3YEC7 baseline and differential
GenevisibleiQ3YEC7 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRABL6_HUMAN
AccessioniPrimary (citable) accession number: Q3YEC7
Secondary accession number(s): A8QVZ7
, A8QVZ8, C6K8I4, C6K8I5, Q4F968, Q5T5R7, Q8IWK1, Q8TCL4, Q8WU94, Q96SR8, Q9BU21, Q9H935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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