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Entry version 112 (17 Jun 2020)
Sequence version 2 (30 Nov 2010)
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Protein

Transmembrane protein 176B

Gene

TMEM176B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.37.8.1 the cd20 ca(2+) channel (cd20) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 176B
Alternative name(s):
Protein LR8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM176B
Synonyms:LR8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000106565.17

Human Gene Nomenclature Database

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HGNCi
HGNC:29596 TMEM176B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610385 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3YBM2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
28959

Open Targets

More...
OpenTargetsi
ENSG00000106565

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405966

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q3YBM2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM176B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002798751 – 270Transmembrane protein 176BAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei236PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1
Modified residuei254PhosphoserineBy similarity1
Modified residuei258PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3YBM2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q3YBM2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3YBM2

PeptideAtlas

More...
PeptideAtlasi
Q3YBM2

PRoteomics IDEntifications database

More...
PRIDEi
Q3YBM2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19087
61891 [Q3YBM2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3YBM2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3YBM2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung and dermal fibroblasts.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in fibrotic lung. Down-regulated in activated dendritic cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106565 Expressed in right lobe of liver and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3YBM2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3YBM2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000106565 Tissue enhanced (blood, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118786, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q3YBM2, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000410269

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3YBM2 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM176 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXII Eukaryota
ENOG410ZDNZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064074

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_090530_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3YBM2

Identification of Orthologs from Complete Genome Data

More...
OMAi
WEEDRCR

Database of Orthologous Groups

More...
OrthoDBi
1300114at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3YBM2

TreeFam database of animal gene trees

More...
TreeFami
TF335389

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007237 CD20-like
IPR009281 TMEM176A/TMEM176B

The PANTHER Classification System

More...
PANTHERi
PTHR15756 PTHR15756, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04103 CD20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3YBM2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTQNTVIVNG VAMASRPSQP THVNVHIHQE SALTQLLKAG GSLKKFLFHP
60 70 80 90 100
GDTVPSTARI GYEQLALGVT QILLGVVSCV LGVCLSLGPW TVLSASGCAF
110 120 130 140 150
WAGSVVIAAG AGAIVHEKHP GKLAGYISSL LTLAGFATAM AAVVLCVNSF
160 170 180 190 200
IWQTEPFLYI DTVCDRSDPV FPTTGYRWMR RSQENQWQKE ECRAYMQMLR
210 220 230 240 250
KLFTAIRALF LAVCVLKVIV SLVSLGVGLR NLCGQSSQPL NEEGSEKRLL
260 270
GENSVPPSPS REQTSTAIVL
Length:270
Mass (Da):29,056
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D27B2A384709FDD
GO
Isoform 2 (identifier: Q3YBM2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-105: Missing.

Show »
Length:233
Mass (Da):25,379
Checksum:iD6B82DA53CCE8D08
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH91471 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17 – 18PS → HA in AAD23440 (PubMed:9922225).Curated2
Sequence conflicti237S → P in AK129525 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05776640G → E. Corresponds to variant dbSNP:rs10240587Ensembl.1
Natural variantiVAR_03103555P → S1 PublicationCorresponds to variant dbSNP:rs11546671Ensembl.1
Natural variantiVAR_03103670T → A. Corresponds to variant dbSNP:rs28434777Ensembl.1
Natural variantiVAR_03103794S → R3 PublicationsCorresponds to variant dbSNP:rs3173833Ensembl.1
Natural variantiVAR_031038134A → T1 PublicationCorresponds to variant dbSNP:rs2072443Ensembl.1
Natural variantiVAR_031039180R → W. Corresponds to variant dbSNP:rs17256042Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04628369 – 105Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF115384 mRNA Translation: AAD23440.1
DQ144974 mRNA Translation: AAZ75648.1
AK129525 mRNA No translation available.
AK315575 mRNA Translation: BAG37949.1
AC006479 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW54077.1
CH471173 Genomic DNA Translation: EAW54078.1
CH471173 Genomic DNA Translation: EAW54079.1
CH471173 Genomic DNA Translation: EAW54080.1
BC004358 mRNA Translation: AAH04358.1
BC014586 mRNA Translation: AAH14586.1
BC091471 mRNA Translation: AAH91471.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47746.1 [Q3YBM2-2]
CCDS5908.1 [Q3YBM2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001094781.1, NM_001101311.1 [Q3YBM2-1]
NP_001094782.1, NM_001101312.1 [Q3YBM2-1]
NP_001094784.1, NM_001101314.1 [Q3YBM2-2]
NP_054739.3, NM_014020.3 [Q3YBM2-1]
XP_006715996.2, XM_006715933.3 [Q3YBM2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326442; ENSP00000318409; ENSG00000106565 [Q3YBM2-1]
ENST00000429904; ENSP00000397810; ENSG00000106565 [Q3YBM2-1]
ENST00000434545; ENSP00000413531; ENSG00000106565 [Q3YBM2-1]
ENST00000447204; ENSP00000410269; ENSG00000106565 [Q3YBM2-1]
ENST00000450753; ENSP00000404831; ENSG00000106565 [Q3YBM2-2]
ENST00000492607; ENSP00000419258; ENSG00000106565 [Q3YBM2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
28959

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:28959

UCSC genome browser

More...
UCSCi
uc003whu.5 human [Q3YBM2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115384 mRNA Translation: AAD23440.1
DQ144974 mRNA Translation: AAZ75648.1
AK129525 mRNA No translation available.
AK315575 mRNA Translation: BAG37949.1
AC006479 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW54077.1
CH471173 Genomic DNA Translation: EAW54078.1
CH471173 Genomic DNA Translation: EAW54079.1
CH471173 Genomic DNA Translation: EAW54080.1
BC004358 mRNA Translation: AAH04358.1
BC014586 mRNA Translation: AAH14586.1
BC091471 mRNA Translation: AAH91471.1 Sequence problems.
CCDSiCCDS47746.1 [Q3YBM2-2]
CCDS5908.1 [Q3YBM2-1]
RefSeqiNP_001094781.1, NM_001101311.1 [Q3YBM2-1]
NP_001094782.1, NM_001101312.1 [Q3YBM2-1]
NP_001094784.1, NM_001101314.1 [Q3YBM2-2]
NP_054739.3, NM_014020.3 [Q3YBM2-1]
XP_006715996.2, XM_006715933.3 [Q3YBM2-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi118786, 26 interactors
IntActiQ3YBM2, 2 interactors
STRINGi9606.ENSP00000410269

Protein family/group databases

TCDBi1.A.37.8.1 the cd20 ca(2+) channel (cd20) family

PTM databases

iPTMnetiQ3YBM2
PhosphoSitePlusiQ3YBM2

Polymorphism and mutation databases

BioMutaiTMEM176B
DMDMi313104018

Proteomic databases

jPOSTiQ3YBM2
MassIVEiQ3YBM2
PaxDbiQ3YBM2
PeptideAtlasiQ3YBM2
PRIDEiQ3YBM2
ProteomicsDBi19087
61891 [Q3YBM2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32900 90 antibodies

The DNASU plasmid repository

More...
DNASUi
28959

Genome annotation databases

EnsembliENST00000326442; ENSP00000318409; ENSG00000106565 [Q3YBM2-1]
ENST00000429904; ENSP00000397810; ENSG00000106565 [Q3YBM2-1]
ENST00000434545; ENSP00000413531; ENSG00000106565 [Q3YBM2-1]
ENST00000447204; ENSP00000410269; ENSG00000106565 [Q3YBM2-1]
ENST00000450753; ENSP00000404831; ENSG00000106565 [Q3YBM2-2]
ENST00000492607; ENSP00000419258; ENSG00000106565 [Q3YBM2-1]
GeneIDi28959
KEGGihsa:28959
UCSCiuc003whu.5 human [Q3YBM2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
28959
DisGeNETi28959
EuPathDBiHostDB:ENSG00000106565.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM176B
HGNCiHGNC:29596 TMEM176B
HPAiENSG00000106565 Tissue enhanced (blood, liver)
MIMi610385 gene
neXtProtiNX_Q3YBM2
OpenTargetsiENSG00000106565
PharmGKBiPA162405966

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXII Eukaryota
ENOG410ZDNZ LUCA
GeneTreeiENSGT00530000064074
HOGENOMiCLU_090530_0_0_1
InParanoidiQ3YBM2
OMAiWEEDRCR
OrthoDBi1300114at2759
PhylomeDBiQ3YBM2
TreeFamiTF335389

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
28959 2 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEM176B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
28959
PharosiQ3YBM2 Tbio

Protein Ontology

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PROi
PR:Q3YBM2
RNActiQ3YBM2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000106565 Expressed in right lobe of liver and 208 other tissues
ExpressionAtlasiQ3YBM2 baseline and differential
GenevisibleiQ3YBM2 HS

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR009281 TMEM176A/TMEM176B
PANTHERiPTHR15756 PTHR15756, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT176B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3YBM2
Secondary accession number(s): B2RDK2
, D3DWZ7, E9PAV4, Q5BJI2, Q9BT42, Q9Y609
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 30, 2010
Last modified: June 17, 2020
This is version 112 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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