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Protein

Thiamine thiazole synthase

Gene

thi4

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46NADUniRule annotation1
Binding sitei73NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi171Iron; shared with adjacent protomerUniRule annotation1
Binding sitei171NAD; shared with adjacent protomerUniRule annotation1
Metal bindingi186IronUniRule annotation1
Binding sitei258NAD; via amide nitrogenUniRule annotation1
Binding sitei268GlycineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 66NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processThiamine biosynthesis
LigandIron, Metal-binding, NAD

Enzyme and pathway databases

UniPathwayi
UPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine thiazole synthaseUniRule annotation (EC:4.-.-.-UniRule annotation)
Gene namesi
Name:thi4UniRule annotation
Ordered Locus Names:rrnAC1782
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaHalobacterialesHaloarculaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002593781 – 310Thiamine thiazole synthaseAdd BLAST310

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi272569.rrnAC1782

Structurei

3D structure databases

ProteinModelPortaliQ3V7Z9
SMRiQ3V7Z9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THI4 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00574 Archaea
COG1635 LUCA
HOGENOMiHOG000106048
KOiK22699
OrthoDBiPOG093Z09PU

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit

Sequencei

Sequence statusi: Complete.

Q3V7Z9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSDSFEQF SDVGEAEVTR AIGQEWTEEF MDFSDSDVII VGGGPSGLMA
60 70 80 90 100
AKELAERGVQ VMVVEKNNYL GGGFWLGGFL MNKVTVRDPA QQVLDELEVD
110 120 130 140 150
HKRSKDSEGL YVANGPEACS GLIKAACDAG AKMQNMTEFT DIVIREDHRV
160 170 180 190 200
GGIVMNWTPV HALPREITCV DPIAVEADLV IDATGHDAMA VKKLDERGVL
210 220 230 240 250
NAPGLEDEAS GMDQTDDDTY GAPGHDSPGH DSMWVGESED AVVEHTGLAH
260 270 280 290 300
DGLVVTGMAT ATTYGLPRMG PTFGAMLVSG KRAAQVALDE LEVDAEPVDV
310
TSRDATPADD
Length:310
Mass (Da):33,015
Last modified:October 31, 2006 - v2
Checksum:iFA929059A1C2A7E4
GO

Sequence cautioni

The sequence AAV46676 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA Translation: AAV46676.1 Different initiation.
RefSeqiWP_004957848.1, NC_006396.1

Genome annotation databases

EnsemblBacteriaiAAV46676; AAV46676; rrnAC1782
GeneIDi3129209
KEGGihma:rrnAC1782
PATRICifig|272569.17.peg.2456

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA Translation: AAV46676.1 Different initiation.
RefSeqiWP_004957848.1, NC_006396.1

3D structure databases

ProteinModelPortaliQ3V7Z9
SMRiQ3V7Z9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272569.rrnAC1782

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV46676; AAV46676; rrnAC1782
GeneIDi3129209
KEGGihma:rrnAC1782
PATRICifig|272569.17.peg.2456

Phylogenomic databases

eggNOGiarCOG00574 Archaea
COG1635 LUCA
HOGENOMiHOG000106048
KOiK22699
OrthoDBiPOG093Z09PU

Enzyme and pathway databases

UniPathwayi
UPA00060

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHI4_HALMA
AccessioniPrimary (citable) accession number: Q3V7Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 10, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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