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Protein

Integrin alpha-1

Gene

Itga1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi497 – 505Sequence analysis9
Calcium bindingi579 – 587Sequence analysis9
Calcium bindingi641 – 649Sequence analysis9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083 Integrin cell surface interactions
R-MMU-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-1
Alternative name(s):
CD49 antigen-like family member A
Laminin and collagen receptor
VLA-1
CD_antigen: CD49a
Gene namesi
Name:Itga1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:96599 Itga1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 1141ExtracellularSequence analysisAdd BLAST1113
Transmembranei1142 – 1164HelicalSequence analysisAdd BLAST23
Topological domaini1165 – 1179CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
ChainiPRO_000027372229 – 1179Integrin alpha-1By similarityAdd BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 92By similarity
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi687 ↔ 696By similarity
Glycosylationi698N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi702 ↔ 755By similarity
Glycosylationi747N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi779N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi807 ↔ 813By similarity
Glycosylationi839N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi877 ↔ 885By similarity
Glycosylationi882N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi907N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi938N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi965N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi973N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1007N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1029 ↔ 1062By similarity
Disulfide bondi1065 ↔ 1072By similarity
Glycosylationi1083N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1113N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3V3R4
PaxDbiQ3V3R4
PeptideAtlasiQ3V3R4
PRIDEiQ3V3R4

PTM databases

iPTMnetiQ3V3R4
PhosphoSitePlusiQ3V3R4
SwissPalmiQ3V3R4

Expressioni

Gene expression databases

BgeeiENSMUSG00000042284 Expressed in 181 organ(s), highest expression level in urinary bladder
CleanExiMM_ITGA1
GenevisibleiQ3V3R4 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1 (By similarity). Interacts with RAB21 (By similarity). Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-3114 Integrin alpha1-beta1 complex
STRINGi10090.ENSMUSP00000077132

Structurei

3D structure databases

ProteinModelPortaliQ3V3R4
SMRiQ3V3R4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 91FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati101 – 160FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
Domaini175 – 364VWFAPROSITE-ProRule annotationAdd BLAST190
Repeati365 – 417FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati422 – 474FG-GAP 4PROSITE-ProRule annotationAdd BLAST53
Repeati475 – 537FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati556 – 614FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati618 – 678FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1167 – 1171GFFKR motif5

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPB7 Eukaryota
ENOG410YEM8 LUCA
GeneTreeiENSGT00930000150854
HOGENOMiHOG000059610
HOVERGENiHBG006185
InParanoidiQ3V3R4
KOiK06480
OMAiIRKSGHF
OrthoDBiEOG091G00TK
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3V3R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPRRPASLE VTVACIWLLT VILGVCISFN VDVKNSMSFS GPVEDMFGYT
60 70 80 90 100
VQQYENEEGK WVLIGSPLVG QPKARTGDVY KCPVGRERSM PCVKLDLPVN
110 120 130 140 150
TSIPNVTEIK ENMTFGSTLV TNPKGGFLAC GPLYAYRCGH LHYTTGICSD
160 170 180 190 200
VSPTFQVVNS FAPVQECSTQ LDIVIVLDGS NSIYPWESVT AFLNDLLKRM
210 220 230 240 250
DIGPKQTQVG IVQYGANVTH EFNLNKYSST EEVLVAANKI GRRGGLQTMT
260 270 280 290 300
ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNYRL KQVIQDCEDE
310 320 330 340 350
NIQRFSIAIL GHYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT
360 370 380 390 400
IVKALGERIF ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD
410 420 430 440 450
WNGTVVMQKA NQIVIPHNTT FQTEPTKMNE PLASYLGYTV NSATIPGDVL
460 470 480 490 500
YIAGQPRYNH TGQVVIYKME DGDVNILQTL SGEQIGSYFG SVLTTIDIDK
510 520 530 540 550
DSYTDLLLVG APMYMGTEKE EQGKVYVYAV NQTRFEYQMS LEPIKQTCCS
560 570 580 590 600
SLKDNSCTKE NKNEPCGARF GTAVAAVKDL NVDGFNDVVI GAPLEDDHAG
610 620 630 640 650
AVYIYHGSGK TIRKEYAQRI PSGGDGKTLK FFGQSIHGEM DLNGDGLTDV
660 670 680 690 700
TIGGLGGAAL FWARDVAVVK VTMNFEPNKV NIQKKNCRVE GKETVCINAT
710 720 730 740 750
MCFHVKLKSK EDSVYEADLQ YRVTLDSLRQ ISRSFFSGTQ ERRIQRNLTV
760 770 780 790 800
RESECIRHSF YMLDKHDFQD SVRVTLDFNL TDPENGPVLD DALPNSVHGH
810 820 830 840 850
IPFAKDCGNK ERCVSDLTLD VSTTEKNLLI VRSQNDKFNV SLTVKNKGDS
860 870 880 890 900
AYNTRTVVQY SPNLIFSGIE EIQKDSCESN QNITCRVGYP FLRTGDVVNF
910 920 930 940 950
KIIFQFNTSH LSENAIIHLS ATSDSEEPLE SLYDNEVNIS IPVKYEVGLQ
960 970 980 990 1000
FYSSASEHHI SVAANETVPE LINSTKDIGD EINVFYTIRK RGHFPMPELR
1010 1020 1030 1040 1050
LAISFPNLTS DGYPVLYPTG WSSSDNVNCR PRSLEDPLGI NSGKKMTISK
1060 1070 1080 1090 1100
SEVLKRGTIQ DCSTCKIATI TCHLLPSDVS QVNVSLILWK PTFIKAHFSS
1110 1120 1130 1140 1150
LNLTIRGELQ SENSSLTLSS SNRKRELAIQ ISKDGLPGRV PLWVILLSAF
1160 1170
AGLLLLMLLI LALWKIGFFK RPLKKKMEK
Length:1,179
Mass (Da):130,810
Last modified:October 3, 2012 - v2
Checksum:iD158F297AFA8119F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti782D → N in BAE20498 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035870 mRNA Translation: BAE20498.1
AC175538 Genomic DNA No translation available.
CT025598 Genomic DNA No translation available.
CCDSiCCDS36788.1
RefSeqiNP_001028400.2, NM_001033228.3
UniGeneiMm.317280

Genome annotation databases

EnsembliENSMUST00000061673; ENSMUSP00000077132; ENSMUSG00000042284
GeneIDi109700
KEGGimmu:109700
UCSCiuc007rxx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035870 mRNA Translation: BAE20498.1
AC175538 Genomic DNA No translation available.
CT025598 Genomic DNA No translation available.
CCDSiCCDS36788.1
RefSeqiNP_001028400.2, NM_001033228.3
UniGeneiMm.317280

3D structure databases

ProteinModelPortaliQ3V3R4
SMRiQ3V3R4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3114 Integrin alpha1-beta1 complex
STRINGi10090.ENSMUSP00000077132

PTM databases

iPTMnetiQ3V3R4
PhosphoSitePlusiQ3V3R4
SwissPalmiQ3V3R4

Proteomic databases

MaxQBiQ3V3R4
PaxDbiQ3V3R4
PeptideAtlasiQ3V3R4
PRIDEiQ3V3R4

Protocols and materials databases

DNASUi109700
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061673; ENSMUSP00000077132; ENSMUSG00000042284
GeneIDi109700
KEGGimmu:109700
UCSCiuc007rxx.1 mouse

Organism-specific databases

CTDi3672
MGIiMGI:96599 Itga1

Phylogenomic databases

eggNOGiENOG410IPB7 Eukaryota
ENOG410YEM8 LUCA
GeneTreeiENSGT00930000150854
HOGENOMiHOG000059610
HOVERGENiHBG006185
InParanoidiQ3V3R4
KOiK06480
OMAiIRKSGHF
OrthoDBiEOG091G00TK
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-MMU-216083 Integrin cell surface interactions
R-MMU-445355 Smooth Muscle Contraction

Miscellaneous databases

ChiTaRSiItga1 mouse
PROiPR:Q3V3R4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042284 Expressed in 181 organ(s), highest expression level in urinary bladder
CleanExiMM_ITGA1
GenevisibleiQ3V3R4 MM

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITA1_MOUSE
AccessioniPrimary (citable) accession number: Q3V3R4
Secondary accession number(s): F8VQN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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