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Protein

Ubiquitin-associated and SH3 domain-containing protein A

Gene

Ubash3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation.By similarity1 Publication

Miscellaneous

Has very nearly lost all enzyme activity. Has very low, but measurable tyrosine phosphatase activity at pH 5.0.

GO - Molecular functioni

  • phosphatase activity Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-associated and SH3 domain-containing protein A
Alternative name(s):
Suppressor of T-cell receptor signaling 2
Short name:
STS-2
T-cell ubiquitin ligand 1
Short name:
TULA-1
Gene namesi
Name:Ubash3a
ORF Names:Sts2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1926074 Ubash3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004153721 – 624Ubiquitin-associated and SH3 domain-containing protein AAdd BLAST624

Proteomic databases

EPDiQ3V3E1
MaxQBiQ3V3E1
PaxDbiQ3V3E1
PRIDEiQ3V3E1

PTM databases

PhosphoSitePlusiQ3V3E1

Expressioni

Gene expression databases

BgeeiENSMUSG00000042345 Expressed in 35 organ(s), highest expression level in thymus
ExpressionAtlasiQ3V3E1 baseline and differential
GenevisibleiQ3V3E1 MM

Interactioni

Subunit structurei

Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins. Interacts with dynamin (By similarity).By similarity

Protein-protein interaction databases

IntActiQ3V3E1, 6 interactors
STRINGi10090.ENSMUSP00000045890

Structurei

Secondary structure

1624
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ3V3E1
SMRiQ3V3E1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3V3E1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 60UBAPROSITE-ProRule annotationAdd BLAST42
Domaini238 – 303SH3PROSITE-ProRule annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni358 – 624Phosphatase-likeAdd BLAST267

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG3734 Eukaryota
ENOG410YGUZ LUCA
GeneTreeiENSGT00390000018249
HOGENOMiHOG000012936
HOVERGENiHBG018025
InParanoidiQ3V3E1
KOiK18993
OMAiHRTYTFS
OrthoDBiEOG091G0DJ2
PhylomeDBiQ3V3E1
TreeFamiTF313334

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
cd11937 SH3_UBASH3A, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR015940 UBA
IPR009060 UBA-like_sf
IPR035634 UBASH3A_SH3
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
PF14604 SH3_9, 1 hit
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF50044 SSF50044, 1 hit
SSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
PS50030 UBA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q3V3E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGETQLYA KVSNKLKGRS TPSLLDPLLA MGFPTHTALK ALAATGRKTA
60 70 80 90 100
EAAADWLHGH CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESRRQCA
110 120 130 140 150
KNRAHEVFPH VTLCDFFTCE DQKVECLYEA LRRAGDRILG SFPTLVPLVL
160 170 180 190 200
HSSISYLGFF INDSPADAIR EFAMAFATEA AVLADCTIKP CTKQLHLTLA
210 220 230 240 250
HKFYPHHQRT LEQLAKAIQP SHSCQWTAAL YSRDMRFVHY QTLKALFQYK
260 270 280 290 300
PQNADELMLS AGDYIFVDPT QQEEASEGWA IGISHRTGCR GFLPENYTER
310 320 330 340 350
ANEADTWVKH RTYTFNLAMD LNSRKDFEAS CRGNGEPHTP SMSKSVSSIQ
360 370 380 390 400
ALQATISRRG ILVVRHGERV DQVFGKSWLQ QCTTADGKYY RPDLNFPRSL
410 420 430 440 450
PRRSNGIKDF ENDPPLSSCG IFQARLAGEA LLDSGVRVTA VFASPALRCV
460 470 480 490 500
QTAKHILEEL KLEKKLKIRV EPGIFEWMKW EASKATLTFL TLEELKEANF
510 520 530 540 550
NVDLDYRPAL PRCSLMPAES YDQYVERCAV SMGQIINTCP QDMGITLIVS
560 570 580 590 600
HSSALDSCTR PLLGLPPREC GDFAQLVRKI PSLGMCFCEE NREDGKWDLV
610 620
NPPVKTLTHG ANSVFNWRNW ISSN
Length:624
Mass (Da):70,145
Last modified:October 11, 2005 - v1
Checksum:iE40AFB541AC84538
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCF9D6RCF9_MOUSE
Ubiquitin-associated and SH3 domain...
Ubash3a
129Annotation score:
G3UZM7G3UZM7_MOUSE
Ubiquitin-associated and SH3 domain...
Ubash3a
116Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75A → V in BAE41311 (PubMed:16141072).Curated1
Sequence conflicti331C → S in BAE41311 (PubMed:16141072).Curated1
Sequence conflicti337P → S in BAE41311 (PubMed:16141072).Curated1
Sequence conflicti444S → F in BAE41311 (PubMed:16141072).Curated1
Sequence conflicti463E → D in BAE41311 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041690 mRNA Translation: BAE20600.1
AK169696 mRNA Translation: BAE41311.1
CU024900, AC154652, AC167247 Genomic DNA Translation: CAX15943.1
CCDSiCCDS50054.1
RefSeqiNP_808491.2, NM_177823.4
UniGeneiMm.387930

Genome annotation databases

EnsembliENSMUST00000048656; ENSMUSP00000045890; ENSMUSG00000042345
GeneIDi328795
KEGGimmu:328795
UCSCiuc008bus.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041690 mRNA Translation: BAE20600.1
AK169696 mRNA Translation: BAE41311.1
CU024900, AC154652, AC167247 Genomic DNA Translation: CAX15943.1
CCDSiCCDS50054.1
RefSeqiNP_808491.2, NM_177823.4
UniGeneiMm.387930

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D4IX-ray1.95A/B/C/D354-622[»]
3D6AX-ray2.25A/B/C/D354-622[»]
3DB1X-ray2.77A/B/C/D354-622[»]
ProteinModelPortaliQ3V3E1
SMRiQ3V3E1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3V3E1, 6 interactors
STRINGi10090.ENSMUSP00000045890

PTM databases

PhosphoSitePlusiQ3V3E1

Proteomic databases

EPDiQ3V3E1
MaxQBiQ3V3E1
PaxDbiQ3V3E1
PRIDEiQ3V3E1

Protocols and materials databases

DNASUi328795
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048656; ENSMUSP00000045890; ENSMUSG00000042345
GeneIDi328795
KEGGimmu:328795
UCSCiuc008bus.2 mouse

Organism-specific databases

CTDi53347
MGIiMGI:1926074 Ubash3a

Phylogenomic databases

eggNOGiKOG3734 Eukaryota
ENOG410YGUZ LUCA
GeneTreeiENSGT00390000018249
HOGENOMiHOG000012936
HOVERGENiHBG018025
InParanoidiQ3V3E1
KOiK18993
OMAiHRTYTFS
OrthoDBiEOG091G0DJ2
PhylomeDBiQ3V3E1
TreeFamiTF313334

Miscellaneous databases

EvolutionaryTraceiQ3V3E1
PROiPR:Q3V3E1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042345 Expressed in 35 organ(s), highest expression level in thymus
ExpressionAtlasiQ3V3E1 baseline and differential
GenevisibleiQ3V3E1 MM

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
cd11937 SH3_UBASH3A, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR015940 UBA
IPR009060 UBA-like_sf
IPR035634 UBASH3A_SH3
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
PF14604 SH3_9, 1 hit
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF50044 SSF50044, 1 hit
SSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
PS50030 UBA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBS3A_MOUSE
AccessioniPrimary (citable) accession number: Q3V3E1
Secondary accession number(s): Q3TED7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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