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Protein

Cyclin-dependent kinase 15

Gene

Cdk15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81ATPPROSITE-ProRule annotationBy similarity1
Active sitei173Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi58 – 66ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 15 (EC:2.7.11.22By similarity)
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein homolog
Cell division protein kinase 15
Serine/threonine-protein kinase ALS2CR7
Serine/threonine-protein kinase PFTAIRE-2
Gene namesi
Name:Cdk15
Synonyms:Als2cr7, Pftk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3583944 Cdk15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002838221 – 433Cyclin-dependent kinase 15Add BLAST433

Proteomic databases

PaxDbiQ3V3A1
PRIDEiQ3V3A1

PTM databases

iPTMnetiQ3V3A1
PhosphoSitePlusiQ3V3A1

Expressioni

Gene expression databases

BgeeiENSMUSG00000026023 Expressed in 19 organ(s), highest expression level in testis
CleanExiMM_PFTK2
ExpressionAtlasiQ3V3A1 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109886

Structurei

3D structure databases

ProteinModelPortaliQ3V3A1
SMRiQ3V3A1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 336Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00900000140869
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ3V3A1
KOiK15594
OMAiEWFPLPK
PhylomeDBiQ3V3A1

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q3V3A1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQELCAKRL QPGCSCYHRS EGGEAHSCQR SQPGSTEPAV FELTEASSST
60 70 80 90 100
ASFHPRGLEA ASAQKLKSKR PRSNSDSFQE ENLRQGLPWK KSLPFGAASS
110 120 130 140 150
YLNLEKLGEG SYAKVYKGIS RINGQLVALK VISMNAEEGV PFTAIREASL
160 170 180 190 200
LKGLKHANIV LLHDIVHTKE TLTFVFEYMH TDLAQYMSQH PGGLHPHNVR
210 220 230 240 250
LFMFQLLRGL AYIHHQRVLH RDLKPQNLLL SHLGELKLAD FGLARAKSIP
260 270 280 290 300
SQTYSSEVVT LWYRPPDALL GATEYSSELD IWGAGCIFIE MFQGQPLFPG
310 320 330 340 350
VSNILEQLEK IWEVLGVPTE DTWPGVSKLP NYNPEWFPPP KPQSLQIVWD
360 370 380 390 400
RLGGVPEAED LASQMLKGFP RDRVSAQEAL VHDYFSVLPS QLYQLPDEES
410 420 430
LFAVSGVKLK PEMCDLSASY RKRHHLVGVN KCW
Length:433
Mass (Da):48,457
Last modified:April 17, 2007 - v2
Checksum:i9584802B36C2224F
GO
Isoform 21 Publication (identifier: Q3V3A1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-290: Missing.
     336-398: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:80
Mass (Da):9,070
Checksum:i2BB27714BA6271ED
GO
Isoform 3 (identifier: Q3V3A1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-90: Missing.

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):48,329
Checksum:i097287D60D4915F6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E3W997E3W997_MOUSE
Cyclin-dependent kinase 15
Cdk15
435Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0523501 – 290Missing in isoform 2. 1 PublicationAdd BLAST290
Alternative sequenceiVSP_03876690Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_052351336 – 398Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042881 mRNA Translation: BAE20636.1
AC116995 Genomic DNA No translation available.
BC147314 mRNA Translation: AAI47315.1
BC147315 mRNA Translation: AAI47316.1
BC147758 mRNA Translation: AAI47759.1
BC147763 mRNA Translation: AAI47764.1
BC172036 mRNA Translation: AAI72036.1
CCDSiCCDS48273.1 [Q3V3A1-1]
RefSeqiNP_001028545.2, NM_001033373.2 [Q3V3A1-1]
XP_006496113.1, XM_006496050.3
UniGeneiMm.297713

Genome annotation databases

EnsembliENSMUST00000114248; ENSMUSP00000109886; ENSMUSG00000026023 [Q3V3A1-1]
GeneIDi271697
KEGGimmu:271697
UCSCiuc007bdq.2 mouse [Q3V3A1-3]
uc007bdr.2 mouse [Q3V3A1-1]
uc007bds.2 mouse [Q3V3A1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042881 mRNA Translation: BAE20636.1
AC116995 Genomic DNA No translation available.
BC147314 mRNA Translation: AAI47315.1
BC147315 mRNA Translation: AAI47316.1
BC147758 mRNA Translation: AAI47759.1
BC147763 mRNA Translation: AAI47764.1
BC172036 mRNA Translation: AAI72036.1
CCDSiCCDS48273.1 [Q3V3A1-1]
RefSeqiNP_001028545.2, NM_001033373.2 [Q3V3A1-1]
XP_006496113.1, XM_006496050.3
UniGeneiMm.297713

3D structure databases

ProteinModelPortaliQ3V3A1
SMRiQ3V3A1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109886

PTM databases

iPTMnetiQ3V3A1
PhosphoSitePlusiQ3V3A1

Proteomic databases

PaxDbiQ3V3A1
PRIDEiQ3V3A1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114248; ENSMUSP00000109886; ENSMUSG00000026023 [Q3V3A1-1]
GeneIDi271697
KEGGimmu:271697
UCSCiuc007bdq.2 mouse [Q3V3A1-3]
uc007bdr.2 mouse [Q3V3A1-1]
uc007bds.2 mouse [Q3V3A1-2]

Organism-specific databases

CTDi65061
MGIiMGI:3583944 Cdk15

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00900000140869
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ3V3A1
KOiK15594
OMAiEWFPLPK
PhylomeDBiQ3V3A1

Miscellaneous databases

PROiPR:Q3V3A1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026023 Expressed in 19 organ(s), highest expression level in testis
CleanExiMM_PFTK2
ExpressionAtlasiQ3V3A1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDK15_MOUSE
AccessioniPrimary (citable) accession number: Q3V3A1
Secondary accession number(s): B2RVR3, B7ZWG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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