UniProtKB - Q3V300 (KIF22_MOUSE)

BLAST

>sp|Q3V300|KIF22_MOUSE Kinesin-like protein KIF22 OS=Mus musculus OX=10090 GN=Kif22 PE=2 SV=2
MSLRAKTCPQRREMASATSGPGRCVSKGGLGRRPPLARVRVAVRLRPFMDGETEAKELPC
VRAIDSCSLEVANWKKYQETLKYQFDAFYGEKSTQQEVYVGSVQPILRHLLEGQNASVLA
YGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLAREESAEGRPWDVSVAMSYLEIYQEKVL
DLLDPASGDLVIREDCRGNILIPGLTQKPITSFSDFEQHFLPASRNRAVGATRLNQRSSR
SHAVLLVKVDQRERLTPFRQREGKLYLIDLAGSEDNRRTGNQGIRLKESGAINTSLFVLG
KVVDALNQGLPRIPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYQDTISALNFTARS
KEVINRPFTNESLQPHALAPVKLSQKELLGPSEAKKAKGPEEESTGSPESTAAPASASQK
LSLLQKLSNMDPAMLENLLSMERLLGSQGSQGTPLLNTPKRERMVLMKTVEEKNLEIERL
KMKQKELEAKVLAQEAPDPREKENTPTILQPPASYSGTVAKPLKKAVVMPLQRIQKQRES
SNQIQLLKKGPKRKLEPSPESEAVEKDEDYWEVQISPELLAHGRKKLLDLLNEGSARELR
SLQRIGQKKAQLIVGWRELHGPFSEVEDLEQVEGISGKQVESFLKANLLSLAASQHSGPS

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History
Entry version 114 (07 Nov 2018)
Sequence version 2 (28 Nov 2006)
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Protein

Kinesin-like protein KIF22

Gene

Kif22

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	122 – 129	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ATP binding Source: UniProtKB-KW
DNA binding Source: UniProtKB-KW
microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
microtubule motor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA repair Source: InterPro
metaphase plate congression Source: UniProtKB
microtubule-based movement
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitotic metaphase plate congression Source: UniProtKB
sister chromatid cohesion Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Motor protein
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2132295 MHC class II antigen presentation R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189 Kinesins

Reactomeⁱ

R-MMU-2132295 MHC class II antigen presentation
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kinesin-like protein KIF22
Gene namesⁱ	Name:Kif22
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:109233 Kif22

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000262921	1 – 660	Kinesin-like protein KIF22Add BLAST		660

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	407	PhosphoserineBy similarity	1
Modified residueⁱ	422	PhosphoserineBy similarity	1
Modified residueⁱ	447	PhosphoserineBy similarity	1
Cross-linkⁱ	460	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	540	PhosphoserineBy similarity	1
Modified residueⁱ	576	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q3V300
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3V300
PaxDbⁱ	Q3V300
PeptideAtlas More...PeptideAtlasⁱ	Q3V300
PRIDEⁱ	Q3V300

PTM databases

iPTMnetⁱ	Q3V300
PhosphoSitePlusⁱ	Q3V300

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030677 Expressed in 292 organ(s), highest expression level in thymus
CleanExⁱ	MM_KIF22
ExpressionAtlasⁱ	Q3V300 baseline and differential
Genevisibleⁱ	Q3V300 MM

Interactionⁱ

Subunit structureⁱ

Interacts with FAM83D and SIAH1.By similarity

GO - Molecular functionⁱ

microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	225240, 5 interactors
IntActⁱ	Q3V300, 7 interactors
STRINGⁱ	10090.ENSMUSP00000032915

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3V300
SMRⁱ	Q3V300
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	38 – 363	Kinesin motorPROSITE-ProRule annotationAdd BLAST		326

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	460 – 505	Sequence analysisAdd BLAST		46

Sequence similaritiesⁱ

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0242 Eukaryota COG5059 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150846
HOGENOMⁱ	HOG000007569
HOVERGENⁱ	HBG052252
InParanoidⁱ	Q3V300
KEGG Orthology (KO) More...KOⁱ	K10403
OMAⁱ	AGQRCGP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FFB
PhylomeDBⁱ	Q3V300
TreeFamⁱ	TF105233

Family and domain databases

Gene3Dⁱ	3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif IPR026986 KIF22 IPR027640 Kinesin-like_fam IPR019821 Kinesin_motor_CS IPR001752 Kinesin_motor_dom IPR036961 Kinesin_motor_dom_sf IPR027417 P-loop_NTPase IPR010994 RuvA_2-like
PANTHERⁱ	PTHR24115 PTHR24115, 1 hit PTHR24115:SF462 PTHR24115:SF462, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00225 Kinesin, 1 hit
PRINTSⁱ	PR00380 KINESINHEAVY
SMARTⁱ	View protein in SMART SM00278 HhH1, 2 hits SM00129 KISc, 1 hit
SUPFAMⁱ	SSF47781 SSF47781, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00411 KINESIN_MOTOR_1, 1 hit PS50067 KINESIN_MOTOR_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q3V300-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLRAKTCPQ RREMASATSG PGRCVSKGGL GRRPPLARVR VAVRLRPFMD 
        60         70         80         90        100
GETEAKELPC VRAIDSCSLE VANWKKYQET LKYQFDAFYG EKSTQQEVYV 
       110        120        130        140        150
GSVQPILRHL LEGQNASVLA YGPTGAGKTH TMLGSPEQPG VIPRALMDLL 
       160        170        180        190        200
QLAREESAEG RPWDVSVAMS YLEIYQEKVL DLLDPASGDL VIREDCRGNI 
       210        220        230        240        250
LIPGLTQKPI TSFSDFEQHF LPASRNRAVG ATRLNQRSSR SHAVLLVKVD 
       260        270        280        290        300
QRERLTPFRQ REGKLYLIDL AGSEDNRRTG NQGIRLKESG AINTSLFVLG 
       310        320        330        340        350
KVVDALNQGL PRIPYRDSKL TRLLQDSLGG SAHSILIANI APERRFYQDT 
       360        370        380        390        400
ISALNFTARS KEVINRPFTN ESLQPHALAP VKLSQKELLG PSEAKKAKGP 
       410        420        430        440        450
EEESTGSPES TAAPASASQK LSLLQKLSNM DPAMLENLLS MERLLGSQGS 
       460        470        480        490        500
QGTPLLNTPK RERMVLMKTV EEKNLEIERL KMKQKELEAK VLAQEAPDPR 
       510        520        530        540        550
EKENTPTILQ PPASYSGTVA KPLKKAVVMP LQRIQKQRES SNQIQLLKKG 
       560        570        580        590        600
PKRKLEPSPE SEAVEKDEDY WEVQISPELL AHGRKKLLDL LNEGSARELR 
       610        620        630        640        650
SLQRIGQKKA QLIVGWRELH GPFSEVEDLE QVEGISGKQV ESFLKANLLS 
       660
LAASQHSGPS

Length:660

Mass (Da):73,190

Last modified:November 28, 2006 - v2

Checksum:ⁱAA8B99477BC49B3C

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0U1RPH8	A0A0U1RPH8_MOUSE	Kinesin-like protein KIF22 Kinesin-like protein KIF22	Kif22	161	Annotation score:
A0A0U1RNY7	A0A0U1RNY7_MOUSE	Kinesin-like protein KIF22 Kinesin-like protein KIF22	Kif22	151	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	60	C → R in BAE43356 (PubMed:15489334).Curated	1
Sequence conflictⁱ	267	L → I in BAE43356 (PubMed:15489334).Curated	1
Sequence conflictⁱ	528	V → E in BAE43356 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK075922 mRNA Translation: BAE43356.1 BC003427 mRNA Translation: AAH03427.1 AF013119 mRNA Translation: AAC39968.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21855.1
NCBI Reference Sequences More...RefSeqⁱ	NP_663563.1, NM_145588.1
UniGeneⁱ	Mm.286488

Genome annotation databases

Ensemblⁱ	ENSMUST00000032915; ENSMUSP00000032915; ENSMUSG00000030677
GeneIDⁱ	110033
KEGGⁱ	mmu:110033
UCSC genome browser More...UCSCⁱ	uc009jud.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3V300	Kinesin-like protein KIF22		RAT		657	UniRef90_Q3V300
Kinesin-like protein KIF22 (Fragment)		MOUSE		161
UPI000A317C3D		MUSCR		690
UPI000A3119D1		MUSPA		660
UPI000A319267		MUSCR		671
+2

Protein	Similar proteins		Species	Score	Length	Source
Q3V300	Kinesin-like protein KIF22	)	HUMAN		665	UniRef50_Q14807
Kinesin-like protein KIF22		PONAB		665
Kinesin-like protein KIF22-B		XENLA		650
Kinesin-like protein KIF22		XENTR		639
Kinesin-like protein KIF22		DANRE		634
+297

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK075922 mRNA Translation: BAE43356.1 BC003427 mRNA Translation: AAH03427.1 AF013119 mRNA Translation: AAC39968.1
CCDSⁱ	CCDS21855.1
RefSeqⁱ	NP_663563.1, NM_145588.1
UniGeneⁱ	Mm.286488

3D structure databases

ProteinModelPortalⁱ	Q3V300
SMRⁱ	Q3V300
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	225240, 5 interactors
IntActⁱ	Q3V300, 7 interactors
STRINGⁱ	10090.ENSMUSP00000032915

PTM databases

iPTMnetⁱ	Q3V300
PhosphoSitePlusⁱ	Q3V300

Proteomic databases

EPDⁱ	Q3V300
MaxQBⁱ	Q3V300
PaxDbⁱ	Q3V300
PeptideAtlasⁱ	Q3V300
PRIDEⁱ	Q3V300

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000032915; ENSMUSP00000032915; ENSMUSG00000030677
GeneIDⁱ	110033
KEGGⁱ	mmu:110033
UCSCⁱ	uc009jud.1 mouse

Organism-specific databases

CTDⁱ	3835
MGIⁱ	MGI:109233 Kif22

Phylogenomic databases

eggNOGⁱ	KOG0242 Eukaryota COG5059 LUCA
GeneTreeⁱ	ENSGT00930000150846
HOGENOMⁱ	HOG000007569
HOVERGENⁱ	HBG052252
InParanoidⁱ	Q3V300
KOⁱ	K10403
OMAⁱ	AGQRCGP
OrthoDBⁱ	EOG091G0FFB
PhylomeDBⁱ	Q3V300
TreeFamⁱ	TF105233

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2132295 MHC class II antigen presentation R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189 Kinesins

Reactomeⁱ

R-MMU-2132295 MHC class II antigen presentation
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3V300
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030677 Expressed in 292 organ(s), highest expression level in thymus
CleanExⁱ	MM_KIF22
ExpressionAtlasⁱ	Q3V300 baseline and differential
Genevisibleⁱ	Q3V300 MM

Family and domain databases

Gene3Dⁱ	3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif IPR026986 KIF22 IPR027640 Kinesin-like_fam IPR019821 Kinesin_motor_CS IPR001752 Kinesin_motor_dom IPR036961 Kinesin_motor_dom_sf IPR027417 P-loop_NTPase IPR010994 RuvA_2-like
PANTHERⁱ	PTHR24115 PTHR24115, 1 hit PTHR24115:SF462 PTHR24115:SF462, 1 hit
Pfamⁱ	View protein in Pfam PF00225 Kinesin, 1 hit
PRINTSⁱ	PR00380 KINESINHEAVY
SMARTⁱ	View protein in SMART SM00278 HhH1, 2 hits SM00129 KISc, 1 hit
SUPFAMⁱ	SSF47781 SSF47781, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00411 KINESIN_MOTOR_1, 1 hit PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KIF22_MOUSE
Accessionⁱ	Q3V300Primary (citable) accession number: Q3V300 Secondary accession number(s): O35232, Q99LC7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	November 28, 2006
	Last modified:	November 7, 2018
	This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3V300 (KIF22_MOUSE)

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Kinesin-like protein KIF22

Kif22

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ