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Protein

Keratinocyte differentiation-associated protein

Gene

Krtdap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity).By similarity

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • epidermis development Source: GO_Central

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Keratinocyte differentiation-associated protein
Gene namesi
Name:KrtdapImported
Synonyms:Kdap1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1928282 Krtdap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031705623 – 102Keratinocyte differentiation-associated proteinSequence analysisAdd BLAST80

Proteomic databases

PaxDbiQ3V2T4
PeptideAtlasiQ3V2T4
PRIDEiQ3V2T4

PTM databases

iPTMnetiQ3V2T4
PhosphoSitePlusiQ3V2T4

Expressioni

Tissue specificityi

Expression restricted to suprabasal keratinocytes of the epidermis.1 Publication

Gene expression databases

BgeeiENSMUSG00000074199 Expressed in 87 organ(s), highest expression level in skin epidermis
CleanExiMM_KRTDAP
ExpressionAtlasiQ3V2T4 baseline and differential
GenevisibleiQ3V2T4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096159

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2MA Eukaryota
ENOG41118KR LUCA
GeneTreeiENSGT00390000009097
HOGENOMiHOG000113266
HOVERGENiHBG108078
InParanoidiQ3V2T4
OMAiEEFLNWH
OrthoDBiEOG091G17JA
PhylomeDBiQ3V2T4
TreeFamiTF341267

Family and domain databases

InterProiView protein in InterPro
IPR028196 KRTDAP
PANTHERiPTHR36463 PTHR36463, 1 hit
PfamiView protein in Pfam
PF15200 KRTDAP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 13 Publications (identifier: Q3V2T4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKIPILPVVA LLSLLALHAV QGAALGHPTI YPEDSSYNNY PTATEGLNNE
60 70 80 90 100
FLNFKRLQSA FQSENFLNWH VITDMFKNAF PFINWDFFPK VKGLRSAAPD

SQ
Length:102
Mass (Da):11,497
Last modified:October 11, 2005 - v1
Checksum:i5EDF30256BA0CD79
GO
Isoform 21 Publication (identifier: Q3V2T4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-102: VKGLRSAAPDSQ → T

Show »
Length:91
Mass (Da):10,388
Checksum:i0D5C2C7F79016E19
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZNU6B7ZNU6_MOUSE
Keratinocyte differentiation-associ...
Krtdap
77Annotation score:
A0A087WRR2A0A087WRR2_MOUSE
Keratinocyte differentiation-associ...
Krtdap mCG_133483
88Annotation score:
A0A087WR64A0A087WR64_MOUSE
Keratinocyte differentiation-associ...
Krtdap
57Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2K → R in BAE20716 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05266091 – 102VKGLR…APDSQ → T in isoform 2. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131603 mRNA Translation: BAE20713.1
AK131606 mRNA Translation: BAE20716.1
BC132510 mRNA Translation: AAI32511.1
BC132512 mRNA Translation: AAI32513.1
BC145438 mRNA Translation: AAI45439.1
CCDSiCCDS21110.1 [Q3V2T4-1]
RefSeqiNP_001028303.1, NM_001033131.3 [Q3V2T4-1]
UniGeneiMm.268157

Genome annotation databases

EnsembliENSMUST00000098559; ENSMUSP00000096159; ENSMUSG00000074199 [Q3V2T4-1]
ENSMUST00000190990; ENSMUSP00000139461; ENSMUSG00000074199 [Q3V2T4-2]
GeneIDi64661
KEGGimmu:64661
UCSCiuc009ggl.1 mouse [Q3V2T4-2]
uc009ggm.1 mouse [Q3V2T4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131603 mRNA Translation: BAE20713.1
AK131606 mRNA Translation: BAE20716.1
BC132510 mRNA Translation: AAI32511.1
BC132512 mRNA Translation: AAI32513.1
BC145438 mRNA Translation: AAI45439.1
CCDSiCCDS21110.1 [Q3V2T4-1]
RefSeqiNP_001028303.1, NM_001033131.3 [Q3V2T4-1]
UniGeneiMm.268157

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096159

PTM databases

iPTMnetiQ3V2T4
PhosphoSitePlusiQ3V2T4

Proteomic databases

PaxDbiQ3V2T4
PeptideAtlasiQ3V2T4
PRIDEiQ3V2T4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098559; ENSMUSP00000096159; ENSMUSG00000074199 [Q3V2T4-1]
ENSMUST00000190990; ENSMUSP00000139461; ENSMUSG00000074199 [Q3V2T4-2]
GeneIDi64661
KEGGimmu:64661
UCSCiuc009ggl.1 mouse [Q3V2T4-2]
uc009ggm.1 mouse [Q3V2T4-1]

Organism-specific databases

CTDi388533
MGIiMGI:1928282 Krtdap

Phylogenomic databases

eggNOGiENOG410J2MA Eukaryota
ENOG41118KR LUCA
GeneTreeiENSGT00390000009097
HOGENOMiHOG000113266
HOVERGENiHBG108078
InParanoidiQ3V2T4
OMAiEEFLNWH
OrthoDBiEOG091G17JA
PhylomeDBiQ3V2T4
TreeFamiTF341267

Miscellaneous databases

ChiTaRSiKrtdap mouse
PROiPR:Q3V2T4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074199 Expressed in 87 organ(s), highest expression level in skin epidermis
CleanExiMM_KRTDAP
ExpressionAtlasiQ3V2T4 baseline and differential
GenevisibleiQ3V2T4 MM

Family and domain databases

InterProiView protein in InterPro
IPR028196 KRTDAP
PANTHERiPTHR36463 PTHR36463, 1 hit
PfamiView protein in Pfam
PF15200 KRTDAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKTDAP_MOUSE
AccessioniPrimary (citable) accession number: Q3V2T4
Secondary accession number(s): B7ZNU7, Q3V2T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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