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Protein

ESF1 homolog

Gene

Esf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity).By similarity

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ESF1 homolog
Alternative name(s):
ABT1-associated protein
Gene namesi
Name:Esf1
Synonyms:Abtap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913830 Esf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002331662 – 845ESF1 homologAdd BLAST844

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1
Modified residuei82PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei156PhosphoserineCombined sources1
Modified residuei200PhosphoserineBy similarity1
Modified residuei290PhosphoserineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei305PhosphothreonineCombined sources1
Modified residuei306PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei608PhosphoserineBy similarity1
Modified residuei651PhosphoserineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei686PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei729PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3V1V3
MaxQBiQ3V1V3
PaxDbiQ3V1V3
PRIDEiQ3V1V3

PTM databases

iPTMnetiQ3V1V3
PhosphoSitePlusiQ3V1V3

Expressioni

Gene expression databases

BgeeiENSMUSG00000045624 Expressed in 287 organ(s), highest expression level in embryo
ExpressionAtlasiQ3V1V3 baseline and differential
GenevisibleiQ3V1V3 MM

Interactioni

Subunit structurei

Interacts with ABT1. Forms a complex with ABT1 and suppresses the ABT1-induced activation of polymerase II-directed transcription in mammalian cells (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036523

Structurei

3D structure databases

ProteinModelPortaliQ3V1V3
SMRiQ3V1V3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili775 – 803Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 212Lys-richAdd BLAST126
Compositional biasi231 – 329Glu-richAdd BLAST99
Compositional biasi561 – 740Lys-richAdd BLAST180

Sequence similaritiesi

Belongs to the ESF1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2318 Eukaryota
COG5638 LUCA
GeneTreeiENSGT00390000004881
HOGENOMiHOG000182523
HOVERGENiHBG051149
InParanoidiQ3V1V3
OMAiLTWDETA
OrthoDBiEOG091G0A19
PhylomeDBiQ3V1V3
TreeFamiTF105822

Family and domain databases

InterProiView protein in InterPro
IPR039754 Esf1
IPR012580 NUC153
PANTHERiPTHR12202 PTHR12202, 2 hits
PfamiView protein in Pfam
PF08159 NUC153, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3V1V3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKQEIMDD QRFRRVSKDP RFWEMPEKER KVKIDKRFRA MFHDKKFKLN
60 70 80 90 100
YAVDKRGRPI SHSTTEDLKR FYDLSDSDSD LSDEESKILS QKKAKQKKKQ
110 120 130 140 150
TKKEAKSIEK PIEEKKKETK KTDQKDSINK HDLNNSERVQ KMKNSQKPQK
160 170 180 190 200
IDSEISPKKD NEEFLQNKKK KRGTTDLSVE ALPKGKLRTK DSSTSEMVKS
210 220 230 240 250
STMSSSKAKR EKQSVVPVIM AKDNDGKMPD EDALEEDSDS ASELGSDEES
260 270 280 290 300
EDEIISDGKT SADEDESEEE DEEEEEDSEE EEEEEEEDES DSGPDLARGK
310 320 330 340 350
GNVETSSEDE DDLADLFPEE PGFEHAWREL DKDAPRADEI TRRLAVCNMD
360 370 380 390 400
WDRLKAKDLL ALFNSFKPKG GVVFSVKIYP SEFGKERMKE EQVQGPVELL
410 420 430 440 450
SIPEDAPEKD WASREKLRDY QFKRLKYYYA VAECDSPETA SKIYEDCDGL
460 470 480 490 500
EFESSCSFID LRFIPDDITF DDEPKDVALE VDLTAYKPKY FTSAAMGTST
510 520 530 540 550
VEITWDETDH ERITTLNRKF KKDELLDMDF QAYLASSSED EEEVEEAPEG
560 570 580 590 600
EEGVNIGEDG KTKKSQKDDE EQIAKYRQLL QVIQEKEKKG KENDMEMEIK
610 620 630 640 650
WVPGLKESAE EMVKNKLEGK DKLTPWEQFL EKKKEKKRLK KKQKALAEED
660 670 680 690 700
SEDELPSDVD FNDPYFAEEV KKIGIKKKSM KSAKDSASSE EETDLEKQKA
710 720 730 740 750
EMALLVMDEE EDSKKHFNYD KIVEHQNLSK KKKKQLMKKK ELVEDDFEVN
760 770 780 790 800
VSDARFQAMY TSHLFNLDPS DPNFKKTKAM EKILEEKARH RERKEELLIQ
810 820 830 840
AVERAQQDTG KPTQKQPMDP ALSMLIKSVK NKTEQFQARK KQRVK
Length:845
Mass (Da):98,048
Last modified:October 11, 2005 - v1
Checksum:i8EB7F2C2CFB997F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132230 mRNA Translation: BAE21046.1
CCDSiCCDS38250.1
RefSeqiNP_001074559.1, NM_001081090.1
XP_006500074.1, XM_006500011.3
UniGeneiMm.21228

Genome annotation databases

EnsembliENSMUST00000046030; ENSMUSP00000036523; ENSMUSG00000045624
GeneIDi66580
KEGGimmu:66580
UCSCiuc008mpn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132230 mRNA Translation: BAE21046.1
CCDSiCCDS38250.1
RefSeqiNP_001074559.1, NM_001081090.1
XP_006500074.1, XM_006500011.3
UniGeneiMm.21228

3D structure databases

ProteinModelPortaliQ3V1V3
SMRiQ3V1V3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036523

PTM databases

iPTMnetiQ3V1V3
PhosphoSitePlusiQ3V1V3

Proteomic databases

EPDiQ3V1V3
MaxQBiQ3V1V3
PaxDbiQ3V1V3
PRIDEiQ3V1V3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046030; ENSMUSP00000036523; ENSMUSG00000045624
GeneIDi66580
KEGGimmu:66580
UCSCiuc008mpn.1 mouse

Organism-specific databases

CTDi51575
MGIiMGI:1913830 Esf1

Phylogenomic databases

eggNOGiKOG2318 Eukaryota
COG5638 LUCA
GeneTreeiENSGT00390000004881
HOGENOMiHOG000182523
HOVERGENiHBG051149
InParanoidiQ3V1V3
OMAiLTWDETA
OrthoDBiEOG091G0A19
PhylomeDBiQ3V1V3
TreeFamiTF105822

Miscellaneous databases

ChiTaRSiEsf1 mouse
PROiPR:Q3V1V3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045624 Expressed in 287 organ(s), highest expression level in embryo
ExpressionAtlasiQ3V1V3 baseline and differential
GenevisibleiQ3V1V3 MM

Family and domain databases

InterProiView protein in InterPro
IPR039754 Esf1
IPR012580 NUC153
PANTHERiPTHR12202 PTHR12202, 2 hits
PfamiView protein in Pfam
PF08159 NUC153, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiESF1_MOUSE
AccessioniPrimary (citable) accession number: Q3V1V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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