Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 103 (08 May 2019)
Sequence version 1 (11 Oct 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

ESF1 homolog

Gene

Esf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ESF1 homolog
Alternative name(s):
ABT1-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Esf1
Synonyms:Abtap
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913830 Esf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002331662 – 845ESF1 homologAdd BLAST844

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1
Modified residuei82PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei156PhosphoserineCombined sources1
Modified residuei200PhosphoserineBy similarity1
Modified residuei290PhosphoserineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei305PhosphothreonineCombined sources1
Modified residuei306PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei608PhosphoserineBy similarity1
Modified residuei651PhosphoserineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei686PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei729PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3V1V3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3V1V3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3V1V3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3V1V3

PRoteomics IDEntifications database

More...
PRIDEi
Q3V1V3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3V1V3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3V1V3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045624 Expressed in 287 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3V1V3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3V1V3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ABT1.

Forms a complex with ABT1 and suppresses the ABT1-induced activation of polymerase II-directed transcription in mammalian cells (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000036523

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3V1V3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili775 – 803Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 212Lys-richAdd BLAST126
Compositional biasi231 – 329Glu-richAdd BLAST99
Compositional biasi561 – 740Lys-richAdd BLAST180

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ESF1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2318 Eukaryota
COG5638 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004881

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000182523

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3V1V3

Identification of Orthologs from Complete Genome Data

More...
OMAi
LTWDETA

Database of Orthologous Groups

More...
OrthoDBi
1300279at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3V1V3

TreeFam database of animal gene trees

More...
TreeFami
TF105822

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039754 Esf1
IPR012580 NUC153

The PANTHER Classification System

More...
PANTHERi
PTHR12202 PTHR12202, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08159 NUC153, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q3V1V3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKQEIMDD QRFRRVSKDP RFWEMPEKER KVKIDKRFRA MFHDKKFKLN
60 70 80 90 100
YAVDKRGRPI SHSTTEDLKR FYDLSDSDSD LSDEESKILS QKKAKQKKKQ
110 120 130 140 150
TKKEAKSIEK PIEEKKKETK KTDQKDSINK HDLNNSERVQ KMKNSQKPQK
160 170 180 190 200
IDSEISPKKD NEEFLQNKKK KRGTTDLSVE ALPKGKLRTK DSSTSEMVKS
210 220 230 240 250
STMSSSKAKR EKQSVVPVIM AKDNDGKMPD EDALEEDSDS ASELGSDEES
260 270 280 290 300
EDEIISDGKT SADEDESEEE DEEEEEDSEE EEEEEEEDES DSGPDLARGK
310 320 330 340 350
GNVETSSEDE DDLADLFPEE PGFEHAWREL DKDAPRADEI TRRLAVCNMD
360 370 380 390 400
WDRLKAKDLL ALFNSFKPKG GVVFSVKIYP SEFGKERMKE EQVQGPVELL
410 420 430 440 450
SIPEDAPEKD WASREKLRDY QFKRLKYYYA VAECDSPETA SKIYEDCDGL
460 470 480 490 500
EFESSCSFID LRFIPDDITF DDEPKDVALE VDLTAYKPKY FTSAAMGTST
510 520 530 540 550
VEITWDETDH ERITTLNRKF KKDELLDMDF QAYLASSSED EEEVEEAPEG
560 570 580 590 600
EEGVNIGEDG KTKKSQKDDE EQIAKYRQLL QVIQEKEKKG KENDMEMEIK
610 620 630 640 650
WVPGLKESAE EMVKNKLEGK DKLTPWEQFL EKKKEKKRLK KKQKALAEED
660 670 680 690 700
SEDELPSDVD FNDPYFAEEV KKIGIKKKSM KSAKDSASSE EETDLEKQKA
710 720 730 740 750
EMALLVMDEE EDSKKHFNYD KIVEHQNLSK KKKKQLMKKK ELVEDDFEVN
760 770 780 790 800
VSDARFQAMY TSHLFNLDPS DPNFKKTKAM EKILEEKARH RERKEELLIQ
810 820 830 840
AVERAQQDTG KPTQKQPMDP ALSMLIKSVK NKTEQFQARK KQRVK
Length:845
Mass (Da):98,048
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EB7F2C2CFB997F5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK132230 mRNA Translation: BAE21046.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38250.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074559.1, NM_001081090.1
XP_006500074.1, XM_006500011.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000046030; ENSMUSP00000036523; ENSMUSG00000045624

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66580

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:66580

UCSC genome browser

More...
UCSCi
uc008mpn.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132230 mRNA Translation: BAE21046.1
CCDSiCCDS38250.1
RefSeqiNP_001074559.1, NM_001081090.1
XP_006500074.1, XM_006500011.3

3D structure databases

SMRiQ3V1V3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036523

PTM databases

iPTMnetiQ3V1V3
PhosphoSitePlusiQ3V1V3

Proteomic databases

EPDiQ3V1V3
jPOSTiQ3V1V3
MaxQBiQ3V1V3
PaxDbiQ3V1V3
PRIDEiQ3V1V3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046030; ENSMUSP00000036523; ENSMUSG00000045624
GeneIDi66580
KEGGimmu:66580
UCSCiuc008mpn.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51575
MGIiMGI:1913830 Esf1

Phylogenomic databases

eggNOGiKOG2318 Eukaryota
COG5638 LUCA
GeneTreeiENSGT00390000004881
HOGENOMiHOG000182523
InParanoidiQ3V1V3
OMAiLTWDETA
OrthoDBi1300279at2759
PhylomeDBiQ3V1V3
TreeFamiTF105822

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Esf1 mouse

Protein Ontology

More...
PROi
PR:Q3V1V3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045624 Expressed in 287 organ(s), highest expression level in embryo
ExpressionAtlasiQ3V1V3 baseline and differential
GenevisibleiQ3V1V3 MM

Family and domain databases

InterProiView protein in InterPro
IPR039754 Esf1
IPR012580 NUC153
PANTHERiPTHR12202 PTHR12202, 2 hits
PfamiView protein in Pfam
PF08159 NUC153, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESF1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3V1V3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 11, 2005
Last modified: May 8, 2019
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again