UniProtKB - Q3V1Q3 (Q3V1Q3_MOUSE)
Protein
Adenylate cyclase type 2
Gene
Adcy2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.UniRule annotation
Catalytic activityi
- EC:4.6.1.1UniRule annotationARBA annotation
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 299 | Magnesium 1; catalyticUniRule annotation | 1 | |
Metal bindingi | 299 | Magnesium 2; catalyticUniRule annotation | 1 | |
Metal bindingi | 300 | Magnesium 2; via carbonyl oxygen; catalyticUniRule annotation | 1 | |
Metal bindingi | 343 | Magnesium 1; catalyticUniRule annotation | 1 | |
Metal bindingi | 343 | Magnesium 2; catalyticUniRule annotation | 1 | |
Binding sitei | 387 | ATPUniRule annotation | 1 | |
Binding sitei | 943 | ATPUniRule annotation | 1 | |
Binding sitei | 1070 | ATPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 299 – 304 | ATPUniRule annotation | 6 | |
Nucleotide bindingi | 341 – 343 | ATPUniRule annotation | 3 | |
Nucleotide bindingi | 1023 – 1025 | ATPUniRule annotation | 3 | |
Nucleotide bindingi | 1030 – 1034 | ATPUniRule annotation | 5 |
GO - Molecular functioni
- adenylate cyclase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cAMP biosynthetic process Source: UniProtKB-KW
- intracellular signal transduction Source: InterPro
Keywordsi
Molecular function | LyaseUniRule annotationARBA annotation |
Biological process | cAMP biosynthesisUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, MagnesiumUniRule annotationARBA annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Adcy2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99676, Adcy2 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- cytoplasm Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 50 – 74 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 80 – 102 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 109 – 129 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 135 – 155 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 162 – 180 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 192 – 211 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 604 – 625 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 631 – 656 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 684 – 705 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 743 – 761 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 768 – 786 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 806 – 824 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000021536, Expressed in prefrontal cortex and 293 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 294 – 421 | Guanylate cyclaseInterPro annotationAdd BLAST | 128 | |
Domaini | 891 – 1036 | Guanylate cyclaseInterPro annotationAdd BLAST | 146 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 842 – 862 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156424 |
HOGENOMi | CLU_001072_2_5_1 |
OMAi | MFFLEDN |
OrthoDBi | 363718at2759 |
TreeFami | TF313845 |
Family and domain databases
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR032628, AC_N IPR030672, Adcy IPR009398, Adcy_conserved_dom IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit PF06327, DUF1053, 1 hit PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF039050, Ade_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 2 hits |
SUPFAMi | SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 2 hits PS50125, GUANYLATE_CYCLASE_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q3V1Q3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWQEAMRRRR YLRDRAEAAA AAAAGGGEGL QRSRDWLYES YYCMSQQHPL
60 70 80 90 100
IVFLLLIVMG ACLALLAVFF ALGLEVEDHV AFLITVPTAL AIFFAIFILV
110 120 130 140 150
CIESVFKKLL RVFSLVIWIC LVAMGYLFMC FGGTVSAWDQ VSFFLFIIFV
160 170 180 190 200
VYTMLPFNMR DAIIASVLTS SSHTIVLSVY LSATPGAKEH LFWQILANVI
210 220 230 240 250
IFICGNLAGA YHKHLMELAL QQTYRDTCNC IKSRIKLEFE KRQQERLLLS
260 270 280 290 300
LLPAHIAMEM KAEIIQRLQG PKAGQMENTN NFHNLYVKRH TNVSILYADI
310 320 330 340 350
VGFTRLASDC SPGELVHMLN ELFGKFDQIA KENECMRIKI LGDCYYCVSG
360 370 380 390 400
LPISLPNHAK NCVKMGLDMC EAIKKVRDAT GVDINMRVGV HSGNVLCGVI
410 420 430 440 450
GLQKWQYDVW SHDVTLANHM EAGGVPGRVH ISSVTLEHLN GAYKVEEGDG
460 470 480 490 500
EIRDPYLKQH LVKTYFVINP KGERRSPQHL FRPRHTLDGA KMRASVRMTR
510 520 530 540 550
YLESWGAAKP FAHLHHRDSM TTENGKISTT DVPMGQHNFQ NRTLRTKSQK
560 570 580 590 600
KRFEEELNER MIQAIDGINA QKQWLKSEDI QRISLFFYNK NIEKEYRATA
610 620 630 640 650
LPAFKYYVTC ACLIFLCIFI VQILVLPKTS ILGFSFGAAF LSLIFILFVC
660 670 680 690 700
FAGQLLQCSK KASASLLWLL KSSGIIANRP WPRISLTIVT TAIILTMAVF
710 720 730 740 750
NMFFLSNSEE TTLPTANASN ANVSVPDNQT AILHARNLFF LPYFIYSCIL
760 770 780 790 800
GLISCSVFLR VNYELKMLIM MVALVGYNII LLHTHAHVLD AYSQVLFQRP
810 820 830 840 850
GIWKDLKTMG SVSLSIFFIT LLVLGRQSEY YCRLDFLWKN KFKKEREEIE
860 870 880 890 900
TMENLNRVLL ENVLPAHVAE HFLARSLKNE ELYHQSYDCV CVMFASIPDF
910 920 930 940 950
KEFYTESDVN KEGLECLRLL NEIIADFDDL LSKPKFSGVE KIKTIGSTYM
960 970 980 990 1000
AATGLSAVPS QEHAQEPERQ YMHIGTMVEF AYALVGKLDA INKHSFNDFK
1010 1020 1030 1040 1050
LRVGINHGPV IAGVIGAQKP QYDIWGNTVN VASRMDSTGV LDKIQVTEET
1060 1070 1080 1090
SLILQTLGYT CTCRGIINVK GKGDLKTYFV NTEMSRSLSQ SNLAS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ80TL1 | ADCY2_MOUSE | Adenylate cyclase type 2 | Adcy2 Kiaa1060 | 1,090 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC154389 Genomic DNA No translation available. AC154482 Genomic DNA No translation available. AC239879 Genomic DNA No translation available. CT033781 Genomic DNA No translation available. AK132312 mRNA Translation: BAE21097.1 |
RefSeqi | NP_705762.2, NM_153534.2 |
Genome annotation databases
Ensembli | ENSMUST00000022013; ENSMUSP00000022013; ENSMUSG00000021536 |
GeneIDi | 210044 |
KEGGi | mmu:210044 |
UCSCi | uc007rcf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC154389 Genomic DNA No translation available. AC154482 Genomic DNA No translation available. AC239879 Genomic DNA No translation available. CT033781 Genomic DNA No translation available. AK132312 mRNA Translation: BAE21097.1 |
RefSeqi | NP_705762.2, NM_153534.2 |
3D structure databases
SMRi | Q3V1Q3 |
ModBasei | Search... |
PTM databases
SwissPalmi | Q3V1Q3 |
Proteomic databases
PRIDEi | Q3V1Q3 |
Protocols and materials databases
Antibodypediai | 22409, 170 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022013; ENSMUSP00000022013; ENSMUSG00000021536 |
GeneIDi | 210044 |
KEGGi | mmu:210044 |
UCSCi | uc007rcf.1, mouse |
Organism-specific databases
CTDi | 108 |
MGIi | MGI:99676, Adcy2 |
Phylogenomic databases
GeneTreei | ENSGT00940000156424 |
HOGENOMi | CLU_001072_2_5_1 |
OMAi | MFFLEDN |
OrthoDBi | 363718at2759 |
TreeFami | TF313845 |
Miscellaneous databases
BioGRID-ORCSi | 210044, 0 hits in 17 CRISPR screens |
ChiTaRSi | Adcy2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021536, Expressed in prefrontal cortex and 293 other tissues |
Family and domain databases
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR032628, AC_N IPR030672, Adcy IPR009398, Adcy_conserved_dom IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit PF06327, DUF1053, 1 hit PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF039050, Ade_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 2 hits |
SUPFAMi | SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 2 hits PS50125, GUANYLATE_CYCLASE_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3V1Q3_MOUSE | |
Accessioni | Q3V1Q3Primary (citable) accession number: Q3V1Q3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |