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Protein

Hephaestin-like protein 1

Gene

Hephl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a ferroxidase and may be involved in copper transport and homeostasis.By similarity

Cofactori

Cu cationBy similarityNote: Binds 6 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi126Copper 1; type 2By similarity1
Metal bindingi128Copper 2; type 3By similarity1
Metal bindingi186Copper 2; type 3By similarity1
Metal bindingi188Copper 3; type 3By similarity1
Metal bindingi303Copper 4; type 1By similarity1
Metal bindingi346Copper 4; type 1By similarity1
Metal bindingi351Copper 4; type 1By similarity1
Metal bindingi656Copper 5; type 1By similarity1
Metal bindingi699Copper 5; type 1By similarity1
Metal bindingi704Copper 5; type 1By similarity1
Metal bindingi709Copper 5; type 1By similarity1
Metal bindingi1002Copper 6; type 1By similarity1
Metal bindingi1005Copper 1; type 2By similarity1
Metal bindingi1007Copper 3; type 3By similarity1
Metal bindingi1047Copper 3; type 3By similarity1
Metal bindingi1048Copper 6; type 1By similarity1
Metal bindingi1049Copper 2; type 3By similarity1
Metal bindingi1053Copper 6; type 1By similarity1
Metal bindingi1058Copper 6; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCopper transport, Ion transport, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hephaestin-like protein 1 (EC:1.-.-.-)
Gene namesi
Name:Hephl1
Synonyms:Gm509
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2685355 Hephl1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 1114ExtracellularSequence analysisAdd BLAST1091
Transmembranei1115 – 1135HelicalSequence analysisAdd BLAST21
Topological domaini1136 – 1159CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000034677224 – 1159Hephaestin-like protein 1Add BLAST1136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi180 ↔ 206Sequence analysis
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi284 ↔ 365Sequence analysis
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi534 ↔ 560Sequence analysis
Glycosylationi588N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi637 ↔ 718Sequence analysis
Glycosylationi771N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi880 ↔ 906Sequence analysis
Glycosylationi934N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ3V1H3
MaxQBiQ3V1H3
PaxDbiQ3V1H3
PRIDEiQ3V1H3

PTM databases

PhosphoSitePlusiQ3V1H3

Expressioni

Gene expression databases

BgeeiENSMUSG00000031936 Expressed in 39 organ(s), highest expression level in skin of back
GenevisibleiQ3V1H3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124518

Structurei

3D structure databases

ProteinModelPortaliQ3V1H3
SMRiQ3V1H3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 206Plastocyanin-like 1Add BLAST183
Domaini217 – 365Plastocyanin-like 2Add BLAST149
Domaini378 – 560Plastocyanin-like 3Add BLAST183
Domaini570 – 718Plastocyanin-like 4Add BLAST149
Domaini730 – 906Plastocyanin-like 5Add BLAST177
Domaini914 – 1092Plastocyanin-like 6Add BLAST179

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1122 – 1127Poly-Leu6

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
GeneTreeiENSGT00910000143988
HOGENOMiHOG000231499
HOVERGENiHBG003674
InParanoidiQ3V1H3
OMAiMHAVNGY
OrthoDBiEOG091G00QL
TreeFamiTF329807

Family and domain databases

Gene3Di2.60.40.420, 5 hits
InterProiView protein in InterPro
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
PfamiView protein in Pfam
PF07731 Cu-oxidase_2, 2 hits
PF07732 Cu-oxidase_3, 3 hits
SUPFAMiSSF49503 SSF49503, 6 hits
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 3 hits
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3V1H3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLKQPGGCI LLQFLGLLGL VGAVTRTYYI GIVEEYWNYV PQGKDVITGK
60 70 80 90 100
SFSEDKLATL FLERGPNRIG GIYKKAVYRH FTDGSYSTEI PKPPWLGFLG
110 120 130 140 150
PILRAEVGDV IVIHLMNFAS RPFSLHPHGV FYDKDSEGAL YPDGTSGRNK
160 170 180 190 200
EDDMVPPGKN YTYVWPVREE YAPAPADANC LTWVYHSHID APKDICSGLI
210 220 230 240 250
GPLLVCKEGV LNRYSGMRTD VDREFVIMFT LVDENQSWYL DDNIKQFCTN
260 270 280 290 300
PNSVDKSDAV FQRSNKMHAL NGFLFGNMPE PEMCVGESVS WHLFGMGNEI
310 320 330 340 350
DIHSIYFYGN TFITRGHRAD VVNLFPATFL TTEMIVENPG KWMITCQVSD
360 370 380 390 400
HLQAGMLGQY SVGNCRGNAP HPKVQGQQRR YFIAAEKVLW DYGPQGYDKF
410 420 430 440 450
TGFPLNTSGS DSAVYFTQAD NRIGGKYWKA RYTEYVDATF SRRKMPSDSE
460 470 480 490 500
AHLGILGPVI KAEVGDILLV TFANKADKVY SILPHGVFYD KASDAAPNVD
510 520 530 540 550
GFLKPGAHVK PGETFTYRWT VPESVSPTDE DPPCLTYLYF SAVQPIKDTS
560 570 580 590 600
AGLVGPLLVC KKGTLNADGT QKGIDKEFYL LFTVFDENFS SYLDENIKKF
610 620 630 640 650
TWHPFSVDKE DKEFVKSNRM HAVNGYMYGS QPGLSMCKKD RVSWHLIGMG
660 670 680 690 700
TDTDMHGVYF QGNTIHLRGT HRDSLALFPH MATTAYMQPD HSGIFKVFCS
710 720 730 740 750
TLPHFTRGMG QIYEISSCGN RDPSEPPYGM LRTFFIAAEE VEWDYAPNKN
760 770 780 790 800
WEFEKQHLDA GGERHGDIFM NHTENWIGSQ YRKVVYREYT NGEFVEIKAR
810 820 830 840 850
PPQEEHLQLL GPMIHAEVGD SILIIFKNKA SRPYSIAAQG VEDSNNGKLL
860 870 880 890 900
NVPVTKPGEI KTYRWNVPKR SGPGPSDPNC IPWVYFSTAN FVKDTYSGLM
910 920 930 940 950
GPLITCREGV LNEKGRRSDV DYEFALLFLV FNENESWYLD DNIKKYLNKD
960 970 980 990 1000
PRDFKHTDDF EESNKMHAIN GKIFGNLPGL IMTEDSMTNW YLLGIGSEVD
1010 1020 1030 1040 1050
IHTIHYHAES FLFKIDKSYR EDVYDLFPGT FQTIELFADH PGTWLLHCHV
1060 1070 1080 1090 1100
SDHIHAGMET TYTVLRNIDN RIPYSTKTPS GAGSHAVTVP SQEQPGKEEL
1110 1120 1130 1140 1150
YFFGKNLRPR GAKAALVILF ILGLLLLVAT VVLALRLRSS RRQMAYREVQ

SCALPTDAL
Length:1,159
Mass (Da):130,888
Last modified:September 2, 2008 - v2
Checksum:i3EC317CFF861E96C
GO

Sequence cautioni

The sequence BAE21178 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132457 mRNA Translation: BAE21178.1 Different initiation.
AC154295 Genomic DNA No translation available.
AC156500 Genomic DNA No translation available.
CCDSiCCDS52725.1
RefSeqiNP_001158269.1, NM_001164797.1
UniGeneiMm.325134

Genome annotation databases

EnsembliENSMUST00000159985; ENSMUSP00000124518; ENSMUSG00000031936
GeneIDi244698
KEGGimmu:244698
UCSCiuc009ofj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHPHL1_MOUSE
AccessioniPrimary (citable) accession number: Q3V1H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: September 12, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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