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Protein

Cytoskeleton-associated protein 2

Gene

Ckap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53-dependent manner.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Cell cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoskeleton-associated protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ckap2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1931797 Ckap2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002457751 – 664Cytoskeleton-associated protein 2Add BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei186PhosphoserineBy similarity1
Modified residuei561PhosphothreonineCombined sources1
Modified residuei577PhosphoserineBy similarity1
Modified residuei579PhosphothreonineBy similarity1
Modified residuei584PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3V1H1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3V1H1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3V1H1

PeptideAtlas

More...
PeptideAtlasi
Q3V1H1

PRoteomics IDEntifications database

More...
PRIDEi
Q3V1H1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3V1H1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3V1H1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By constitutively activated RET proteins. By p53/TP53.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037725 Expressed in 185 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
MM_CKAP2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3V1H1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with alpha- and beta-tubulins.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039518

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q3V1H1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni160 – 319Association with alpha- and beta-tubulin1 PublicationAdd BLAST160

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CKAP2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF2W Eukaryota
ENOG4111T8P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063691

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290636

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107703

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3V1H1

KEGG Orthology (KO)

More...
KOi
K16769

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRHTIAK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G05HU

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3V1H1

TreeFam database of animal gene trees

More...
TreeFami
TF333003

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029197 CKAP2_C
IPR026165 CKAP2_fam

The PANTHER Classification System

More...
PANTHERi
PTHR16076 PTHR16076, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15297 CKAP2_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3V1H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESRKRFLG RAARNPLPVT RDLQLPPTRR DQPAFREQRK QKLKEYLLIR
60 70 80 90 100
KTVFPYKQEN QISRDQKMIT SEDRVQEGKK VVKLKTEVAD KENIESTVEK
110 120 130 140 150
NCIPLKAGEV TSSEIHNSKD NVQAVQLLST RDDLPGQTVT LDPACHHKDN
160 170 180 190 200
KKMQMTAEKP KQDSNVSKKR VLGYYHGQIV QSKINSFRKL PSVKGESLTT
210 220 230 240 250
TKKLPTTVSK AMKAQSEPAN TVSVKASTTA AATKFADAKP VSTASKDTLV
260 270 280 290 300
RPPIRSLHSS SHGAAKQGLS RPLANVTVRK GMLDKESHRS EPVVSVVKAG
310 320 330 340 350
SSQAPSRSIA SKDAARTDSS NTRLMVKPKD TDQRRYTIAG ASVHRSAQLK
360 370 380 390 400
DTTAERKAQM TEWRTGKGKG LKRPPHSVVT QAEPKGQSEN PVGSFWTTMA
410 420 430 440 450
EEDEQRLFTE KVNKTISECL NLINEGCPKE EILATLNDLI HNIPDAKKLV
460 470 480 490 500
KYWICLVRIE PITSPIENII SIYEKAILAG AQPIEEMRHI IIDILTTKSQ
510 520 530 540 550
EKVNLGENIE EAHATKEPIQ EVNADANVGS GKPGEENEHH GKVEVYEDDQ
560 570 580 590 600
DNKIKDPDLT TPDSKTEAGC IIRYNVSSTP RLQSMKKMQH DKNSTLKELK
610 620 630 640 650
FLTPVRRSRR IQDKTSRLPA MLKDHDPSVS SLEQLSELGG DAFVCRPNAA
660
LCPLFFETDV AEEE
Length:664
Mass (Da):74,029
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i198278F62F5AE75E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC28747 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti124A → S in BAC28747 (PubMed:16141072).Curated1
Sequence conflicti379V → A in AAU06608 (PubMed:15504249).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY692438 mRNA Translation: AAU06608.1
AK034534 mRNA Translation: BAC28747.1 Different initiation.
AK132463 mRNA Translation: BAE21180.1
BC145666 mRNA Translation: AAI45667.1
BC146023 mRNA Translation: AAI46024.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22170.1

NCBI Reference Sequences

More...
RefSeqi
NP_001004140.2, NM_001004140.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.22448

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000046916; ENSMUSP00000039518; ENSMUSG00000037725

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80986

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:80986

UCSC genome browser

More...
UCSCi
uc009lcs.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY692438 mRNA Translation: AAU06608.1
AK034534 mRNA Translation: BAC28747.1 Different initiation.
AK132463 mRNA Translation: BAE21180.1
BC145666 mRNA Translation: AAI45667.1
BC146023 mRNA Translation: AAI46024.1
CCDSiCCDS22170.1
RefSeqiNP_001004140.2, NM_001004140.2
UniGeneiMm.22448

3D structure databases

ProteinModelPortaliQ3V1H1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039518

PTM databases

iPTMnetiQ3V1H1
PhosphoSitePlusiQ3V1H1

Proteomic databases

EPDiQ3V1H1
MaxQBiQ3V1H1
PaxDbiQ3V1H1
PeptideAtlasiQ3V1H1
PRIDEiQ3V1H1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046916; ENSMUSP00000039518; ENSMUSG00000037725
GeneIDi80986
KEGGimmu:80986
UCSCiuc009lcs.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26586
MGIiMGI:1931797 Ckap2

Phylogenomic databases

eggNOGiENOG410IF2W Eukaryota
ENOG4111T8P LUCA
GeneTreeiENSGT00530000063691
HOGENOMiHOG000290636
HOVERGENiHBG107703
InParanoidiQ3V1H1
KOiK16769
OMAiRRHTIAK
OrthoDBiEOG091G05HU
PhylomeDBiQ3V1H1
TreeFamiTF333003

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ckap2 mouse

Protein Ontology

More...
PROi
PR:Q3V1H1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037725 Expressed in 185 organ(s), highest expression level in secondary oocyte
CleanExiMM_CKAP2
GenevisibleiQ3V1H1 MM

Family and domain databases

InterProiView protein in InterPro
IPR029197 CKAP2_C
IPR026165 CKAP2_fam
PANTHERiPTHR16076 PTHR16076, 1 hit
PfamiView protein in Pfam
PF15297 CKAP2_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCKAP2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3V1H1
Secondary accession number(s): A6H5W7, Q66LN2, Q8BSF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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