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Protein

Cytoskeleton-associated protein 2

Gene

Ckap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53-dependent manner.2 Publications

GO - Biological processi

Keywordsi

Biological processApoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoskeleton-associated protein 2
Gene namesi
Name:Ckap2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1931797 Ckap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002457751 – 664Cytoskeleton-associated protein 2Add BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineBy similarity1
Modified residuei561PhosphothreonineCombined sources1
Modified residuei577PhosphoserineBy similarity1
Modified residuei579PhosphothreonineBy similarity1
Modified residuei584PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3V1H1
MaxQBiQ3V1H1
PaxDbiQ3V1H1
PeptideAtlasiQ3V1H1
PRIDEiQ3V1H1

PTM databases

iPTMnetiQ3V1H1
PhosphoSitePlusiQ3V1H1

Expressioni

Inductioni

By constitutively activated RET proteins. By p53/TP53.2 Publications

Gene expression databases

BgeeiENSMUSG00000037725 Expressed in 185 organ(s), highest expression level in secondary oocyte
CleanExiMM_CKAP2
GenevisibleiQ3V1H1 MM

Interactioni

Subunit structurei

Associates with alpha- and beta-tubulins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039518

Structurei

3D structure databases

ProteinModelPortaliQ3V1H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni160 – 319Association with alpha- and beta-tubulin1 PublicationAdd BLAST160

Sequence similaritiesi

Belongs to the CKAP2 family.Curated

Phylogenomic databases

eggNOGiENOG410IF2W Eukaryota
ENOG4111T8P LUCA
GeneTreeiENSGT00530000063691
HOGENOMiHOG000290636
HOVERGENiHBG107703
InParanoidiQ3V1H1
KOiK16769
OMAiRRHTIAK
OrthoDBiEOG091G05HU
PhylomeDBiQ3V1H1
TreeFamiTF333003

Family and domain databases

InterProiView protein in InterPro
IPR029197 CKAP2_C
IPR026165 CKAP2_fam
PANTHERiPTHR16076 PTHR16076, 1 hit
PfamiView protein in Pfam
PF15297 CKAP2_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q3V1H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESRKRFLG RAARNPLPVT RDLQLPPTRR DQPAFREQRK QKLKEYLLIR
60 70 80 90 100
KTVFPYKQEN QISRDQKMIT SEDRVQEGKK VVKLKTEVAD KENIESTVEK
110 120 130 140 150
NCIPLKAGEV TSSEIHNSKD NVQAVQLLST RDDLPGQTVT LDPACHHKDN
160 170 180 190 200
KKMQMTAEKP KQDSNVSKKR VLGYYHGQIV QSKINSFRKL PSVKGESLTT
210 220 230 240 250
TKKLPTTVSK AMKAQSEPAN TVSVKASTTA AATKFADAKP VSTASKDTLV
260 270 280 290 300
RPPIRSLHSS SHGAAKQGLS RPLANVTVRK GMLDKESHRS EPVVSVVKAG
310 320 330 340 350
SSQAPSRSIA SKDAARTDSS NTRLMVKPKD TDQRRYTIAG ASVHRSAQLK
360 370 380 390 400
DTTAERKAQM TEWRTGKGKG LKRPPHSVVT QAEPKGQSEN PVGSFWTTMA
410 420 430 440 450
EEDEQRLFTE KVNKTISECL NLINEGCPKE EILATLNDLI HNIPDAKKLV
460 470 480 490 500
KYWICLVRIE PITSPIENII SIYEKAILAG AQPIEEMRHI IIDILTTKSQ
510 520 530 540 550
EKVNLGENIE EAHATKEPIQ EVNADANVGS GKPGEENEHH GKVEVYEDDQ
560 570 580 590 600
DNKIKDPDLT TPDSKTEAGC IIRYNVSSTP RLQSMKKMQH DKNSTLKELK
610 620 630 640 650
FLTPVRRSRR IQDKTSRLPA MLKDHDPSVS SLEQLSELGG DAFVCRPNAA
660
LCPLFFETDV AEEE
Length:664
Mass (Da):74,029
Last modified:October 11, 2005 - v1
Checksum:i198278F62F5AE75E
GO

Sequence cautioni

The sequence BAC28747 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124A → S in BAC28747 (PubMed:16141072).Curated1
Sequence conflicti379V → A in AAU06608 (PubMed:15504249).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY692438 mRNA Translation: AAU06608.1
AK034534 mRNA Translation: BAC28747.1 Different initiation.
AK132463 mRNA Translation: BAE21180.1
BC145666 mRNA Translation: AAI45667.1
BC146023 mRNA Translation: AAI46024.1
CCDSiCCDS22170.1
RefSeqiNP_001004140.2, NM_001004140.2
UniGeneiMm.22448

Genome annotation databases

EnsembliENSMUST00000046916; ENSMUSP00000039518; ENSMUSG00000037725
GeneIDi80986
KEGGimmu:80986
UCSCiuc009lcs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY692438 mRNA Translation: AAU06608.1
AK034534 mRNA Translation: BAC28747.1 Different initiation.
AK132463 mRNA Translation: BAE21180.1
BC145666 mRNA Translation: AAI45667.1
BC146023 mRNA Translation: AAI46024.1
CCDSiCCDS22170.1
RefSeqiNP_001004140.2, NM_001004140.2
UniGeneiMm.22448

3D structure databases

ProteinModelPortaliQ3V1H1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039518

PTM databases

iPTMnetiQ3V1H1
PhosphoSitePlusiQ3V1H1

Proteomic databases

EPDiQ3V1H1
MaxQBiQ3V1H1
PaxDbiQ3V1H1
PeptideAtlasiQ3V1H1
PRIDEiQ3V1H1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046916; ENSMUSP00000039518; ENSMUSG00000037725
GeneIDi80986
KEGGimmu:80986
UCSCiuc009lcs.2 mouse

Organism-specific databases

CTDi26586
MGIiMGI:1931797 Ckap2

Phylogenomic databases

eggNOGiENOG410IF2W Eukaryota
ENOG4111T8P LUCA
GeneTreeiENSGT00530000063691
HOGENOMiHOG000290636
HOVERGENiHBG107703
InParanoidiQ3V1H1
KOiK16769
OMAiRRHTIAK
OrthoDBiEOG091G05HU
PhylomeDBiQ3V1H1
TreeFamiTF333003

Miscellaneous databases

ChiTaRSiCkap2 mouse
PROiPR:Q3V1H1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037725 Expressed in 185 organ(s), highest expression level in secondary oocyte
CleanExiMM_CKAP2
GenevisibleiQ3V1H1 MM

Family and domain databases

InterProiView protein in InterPro
IPR029197 CKAP2_C
IPR026165 CKAP2_fam
PANTHERiPTHR16076 PTHR16076, 1 hit
PfamiView protein in Pfam
PF15297 CKAP2_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCKAP2_MOUSE
AccessioniPrimary (citable) accession number: Q3V1H1
Secondary accession number(s): A6H5W7, Q66LN2, Q8BSF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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