UniProtKB - Q3V129 (ULK4_MOUSE)
Protein
Serine/threonine-protein kinase ULK4
Gene
Ulk4
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 121 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: UniProtKB-KW
GO - Biological processi
- adult behavior Source: MGI
- axoneme assembly Source: MGI
- brain development Source: MGI
- central nervous system myelination Source: MGI
- cerebrospinal fluid circulation Source: MGI
- ciliary basal body organization Source: MGI
- corpus callosum development Source: MGI
- epithelial cilium movement involved in extracellular fluid movement Source: MGI
- GABAergic neuron differentiation Source: MGI
- gene expression Source: MGI
- microtubule cytoskeleton organization Source: MGI
- motile cilium assembly Source: MGI
- neurogenesis Source: MGI
- neuroinflammatory response Source: MGI
- neuronal stem cell division Source: MGI
- regulation of JNK cascade Source: MGI
- regulation of MAPK cascade Source: MGI
- regulation of neuron migration Source: MGI
- regulation of neuron projection development Source: MGI
- regulation of p38MAPK cascade Source: MGI
- regulation of protein kinase C signaling Source: MGI
- social behavior Source: MGI
- ventricular system development Source: MGI
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase ULK4 (EC:2.7.11.1)Alternative name(s): Unc-51-like kinase 4 |
Gene namesi | Name:Ulk4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921622, Ulk4 |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: GOC
Pathology & Biotechi
Disruption phenotypei
Knockout mice are smaller than sex-matched littermates, and all exhibit domed heads typical of hydrocephalus. The majority die before reaching 4 months of age. Brain lateral and third ventricles are severaly dilated with frequent hemorrhage, sometimes accompanied by fibrosis and neovascularization of the meninges and choroid. Nasal passages and maxillary sinuses are partially filled with varying combinations of proteinaceous fluid or suppurative exudates. Suppurative otitis media is frequently observed. On the respiratory epithelium and ependymal cells lining the dilated ventricles, cilia are shorter than those in wild-type littermate control mice (PubMed:21746835). Partial agenesis of the corpus callosum has also been reported (PubMed:24284070).2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000250154 | 1 – 1303 | Serine/threonine-protein kinase ULK4Add BLAST | 1303 |
Proteomic databases
PaxDbi | Q3V129 |
PRIDEi | Q3V129 |
PTM databases
PhosphoSitePlusi | Q3V129 |
Expressioni
Tissue specificityi
Expressed in embryonic and adult brain. In the brain, widely expressed, with highest levels in layers II/III and V of the cortex, piriform cortex, CA1-3 of hippocampus, dentate gyrus, ependymal cells lining the ventricles and choroid plexus, and in the thalamic reticular nucleus (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000040936, Expressed in spermatid and 123 other tissues |
ExpressionAtlasi | Q3V129, baseline and differential |
Genevisiblei | Q3V129, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000131342 |
Miscellaneous databases
RNActi | Q3V129, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 280 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 277 | |
Repeati | 504 – 543 | HEAT 1Add BLAST | 40 | |
Repeati | 727 – 765 | HEAT 2Add BLAST | 39 | |
Repeati | 796 – 834 | HEAT 3Add BLAST | 39 | |
Repeati | 926 – 964 | HEAT 4Add BLAST | 39 | |
Repeati | 1025 – 1063 | HEAT 5Add BLAST | 39 | |
Repeati | 1105 – 1143 | HEAT 6Add BLAST | 39 | |
Repeati | 1151 – 1189 | HEAT 7Add BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1147 – 1150 | Poly-Leu | 4 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.PROSITE-ProRule annotation
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0597, Eukaryota |
GeneTreei | ENSGT00940000156541 |
HOGENOMi | CLU_002110_0_0_1 |
InParanoidi | Q3V129 |
OrthoDBi | 219167at2759 |
PhylomeDBi | Q3V129 |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q3V129-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MENFVLYEEI GRGSRTVVYK GRRKGTINFV AILCTEKCKR PEITNWVRLT
60 70 80 90 100
HEIKHKNIVT FHEWYETSNH LWLVVELCTG GSLETVIAQD ENLPEDVVRE
110 120 130 140 150
FGVDLVTGLH HLHRLGILFC DLSPGKILLE GPGTLKFSNF CLAKVAGESL
160 170 180 190 200
EEFFALVAAE EGGGDSGENA LKKSMKTRVR GSLIYAAPEI VKGTEFSVTS
210 220 230 240 250
DLWSLGCLLY EMFSGKPPFF SETVSELVEK ILYEDPLPPI PKDSSFPKAS
260 270 280 290 300
SDFLNLLDGL LQKDPQKRFS WEGVLQHPFW KDALRGEDSG WASEDSPFSR
310 320 330 340 350
NVMECSGPHD SRELLQSPKN GQAKGQKAAH RLSQSFRLEN PTELRPKSIM
360 370 380 390 400
GGQLNESIFL LSSRPTPRTS AMVELNPGEG EDPSSPQKTS PLSKMTSGHL
410 420 430 440 450
SQGALESQMR ELIYTDSDLV ITPIIDNPKI MKQPAIKFDP KILHLPAYSV
460 470 480 490 500
EKLLVLKDQD WNDFLQQVCS QIDSSEKSTG ALRAKLNLLC YLCVVATHKE
510 520 530 540 550
VATRLLHSPL FQLLIQHLRI APNWDIRSKV ARVVGMLALH TTELQENVPV
560 570 580 590 600
IEAITLLTEL IRENFRSGKL KQCLLPTLGQ LLYLVATQEE KNQHSRDCWA
610 620 630 640 650
VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQA QGFTTGEIGP
660 670 680 690 700
VLWHLFRHST VDALRITAIS ALCRITRQSP TAFQNVIEKV GLNAVISSLA
710 720 730 740 750
SAICKVQQYM LTLFTAMLSC GIHLQRLIQE KDFVSTVIRL LDSPSTPIRA
760 770 780 790 800
KAFLVLLYIL IHNRDMLLLS CQARLVMYIE RDSRKTSPGK EQQSGNEYLA
810 820 830 840 850
RCLDLLIQHM VQEPPRILGD ILNALANVSG RKHPSTVQGK QLKMCLPMMP
860 870 880 890 900
VVLHLVMSQV FRPQVVTEEF LFSYGTILSH IKSIDLGETN IDGAIGIVAS
910 920 930 940 950
EEFIKVTLSA FEAVIQYPVL LADYRSTVMD YILPPLVSLV QSQNVEWRLF
960 970 980 990 1000
SLRLLSETTT LLVSQEPEDG DEEASCDSDS SLLALIRDEL LPQYEHILME
1010 1020 1030 1040 1050
PDPVPAYALK LLVAMTEHNP AFTRLVEESK LVPLIFEVIL EHQESILGNT
1060 1070 1080 1090 1100
MQSVIALLNN LVAYKDSNMQ LLYEQGLVGH VCNMFTETAT LCLDRDNKTN
1110 1120 1130 1140 1150
TEPASTLLAS LLDILLGMLT YTSRIVRQAL QVQKSGSRGD TQAAEDLLLL
1160 1170 1180 1190 1200
SKPLTDLISL LIPLLPSEDP EISEVSSKCL SILVQLYGGE NPESLSPENM
1210 1220 1230 1240 1250
VTFANLLMTK EDPKDQKLLL RILKRMVTSN ERLLESLKNT GSLLQALERL
1260 1270 1280 1290 1300
APAHRLRGPW AGISCALFQQ RAAAQGIPEL PPYGIPCCGP SHKRVTGVKL
YPC
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q2P5 | E9Q2P5_MOUSE | Serine/threonine-protein kinase ULK... | Ulk4 | 1,275 | Annotation score: | ||
E9QKJ7 | E9QKJ7_MOUSE | Serine/threonine-protein kinase ULK... | Ulk4 | 1,188 | Annotation score: | ||
E9Q220 | E9Q220_MOUSE | Serine/threonine-protein kinase ULK... | Ulk4 | 139 | Annotation score: | ||
H7BX20 | H7BX20_MOUSE | Serine/threonine-protein kinase ULK... | Ulk4 | 54 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020605 | 1 – 1050 | Missing in isoform 5. 1 PublicationAdd BLAST | 1050 | |
Alternative sequenceiVSP_020606 | 1 – 430 | Missing in isoform 4. 1 PublicationAdd BLAST | 430 | |
Alternative sequenceiVSP_020607 | 527 – 530 | RSKV → LLYV in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_020608 | 531 – 1303 | Missing in isoform 2. 1 PublicationAdd BLAST | 773 | |
Alternative sequenceiVSP_020609 | 775 – 835 | LVMYI…RKHPS → RHSQRPGKRVRPEAPIHGPG EAAEDVSPHDACGASSGDVA GISTSSCDRRVSLQLRNYSC E in isoform 4. 1 PublicationAdd BLAST | 61 | |
Alternative sequenceiVSP_020610 | 836 – 1303 | Missing in isoform 4. 1 PublicationAdd BLAST | 468 | |
Alternative sequenceiVSP_020611 | 879 – 910 | SHIKS…VTLSA → VSSRSHVWPAPLPWLQHGCE KGGIERLSGICL in isoform 3. 2 PublicationsAdd BLAST | 32 | |
Alternative sequenceiVSP_020612 | 911 – 1303 | Missing in isoform 3. 2 PublicationsAdd BLAST | 393 | |
Alternative sequenceiVSP_020613 | 1165 – 1185 | LPSED…SILVQ → VRAHLCASAEVQRLKQFYLN F in isoform 6. 1 PublicationAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK016524 mRNA Translation: BAB30285.1 AK043477 mRNA Translation: BAC31554.1 AK043628 mRNA Translation: BAC31600.1 AK132731 mRNA Translation: BAE21324.1 BC109364 mRNA Translation: AAI09365.1 BC109365 mRNA Translation: AAI09366.1 |
RefSeqi | NP_808257.2, NM_177589.3 |
Genome annotation databases
Ensembli | ENSMUST00000171061; ENSMUSP00000129214; ENSMUSG00000040936 [Q3V129-3] |
GeneIDi | 209012 |
KEGGi | mmu:209012 |
UCSCi | uc009scz.2, mouse [Q3V129-3] uc012hcp.1, mouse [Q3V129-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK016524 mRNA Translation: BAB30285.1 AK043477 mRNA Translation: BAC31554.1 AK043628 mRNA Translation: BAC31600.1 AK132731 mRNA Translation: BAE21324.1 BC109364 mRNA Translation: AAI09365.1 BC109365 mRNA Translation: AAI09366.1 |
RefSeqi | NP_808257.2, NM_177589.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000131342 |
PTM databases
PhosphoSitePlusi | Q3V129 |
Proteomic databases
PaxDbi | Q3V129 |
PRIDEi | Q3V129 |
Protocols and materials databases
Antibodypediai | 6576, 99 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000171061; ENSMUSP00000129214; ENSMUSG00000040936 [Q3V129-3] |
GeneIDi | 209012 |
KEGGi | mmu:209012 |
UCSCi | uc009scz.2, mouse [Q3V129-3] uc012hcp.1, mouse [Q3V129-4] |
Organism-specific databases
CTDi | 54986 |
MGIi | MGI:1921622, Ulk4 |
Phylogenomic databases
eggNOGi | KOG0597, Eukaryota |
GeneTreei | ENSGT00940000156541 |
HOGENOMi | CLU_002110_0_0_1 |
InParanoidi | Q3V129 |
OrthoDBi | 219167at2759 |
PhylomeDBi | Q3V129 |
Miscellaneous databases
BioGRID-ORCSi | 209012, 1 hit in 17 CRISPR screens |
ChiTaRSi | Ulk4, mouse |
PROi | PR:Q3V129 |
RNActi | Q3V129, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040936, Expressed in spermatid and 123 other tissues |
ExpressionAtlasi | Q3V129, baseline and differential |
Genevisiblei | Q3V129, MM |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ULK4_MOUSE | |
Accessioni | Q3V129Primary (citable) accession number: Q3V129 Secondary accession number(s): Q2VP87 Q9D4H6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2006 |
Last sequence update: | September 19, 2006 | |
Last modified: | December 2, 2020 | |
This is version 113 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index