UniProtKB - Q3V100 (Q3V100_MOUSE)
Protein
Mannose-6-phosphate isomerase
Gene
Mpi
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:5.3.1.8UniRule annotationARBA annotation
Cofactori
Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
: GDP-alpha-D-mannose biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.UniRule annotationARBA annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Mannose-6-phosphate isomerase (Mpi), Mannose-6-phosphate isomerase (Mpi), Mannose-6-phosphate isomerase (Mpi), Mannose-6-phosphate isomerase (Mpi)
- Phosphomannomutase 1 (Pmm1), Phosphomannomutase (Pmm2), Phosphomannomutase (Pmm1), Phosphomannomutase (Pmm2), Phosphomannomutase (Pmm1), Phosphomannomutase (Pmm2), Phosphomannomutase (Pmm1), Phosphomannomutase (Pmm1), Phosphomannomutase (Pmm2), Phosphomannomutase 2 (Pmm2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 110 | ZincUniRule annotation | 1 | |
Metal bindingi | 112 | ZincUniRule annotation | 1 | |
Metal bindingi | 137 | ZincUniRule annotation | 1 | |
Metal bindingi | 276 | ZincUniRule annotation | 1 | |
Active sitei | 295 | UniRule annotation | 1 |
GO - Molecular functioni
- mannose-6-phosphate isomerase activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | IsomeraseUniRule annotationARBA annotation |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00126;UER00423 |
Names & Taxonomyi
Protein namesi | Recommended name: Mannose-6-phosphate isomeraseUniRule annotationARBA annotation (EC:5.3.1.8UniRule annotationARBA annotation) |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97075, Mpi |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032306, Expressed in spermatocyte and 274 other tissues |
ExpressionAtlasi | Q3V100, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_026967_2_0_1 |
OMAi | CADQPLS |
OrthoDBi | 1043197at2759 |
Family and domain databases
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR001250, Man6P_Isoase-1 IPR016305, Mannose-6-P_Isomerase IPR018050, Pmannose_isomerase-type1_CS IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR10309, PTHR10309, 1 hit |
Pfami | View protein in Pfam PF01238, PMI_typeI, 1 hit |
PIRSFi | PIRSF001480, Mannose-6-phosphate_isomerase, 1 hit |
PRINTSi | PR00714, MAN6PISMRASE |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR00218, manA, 1 hit |
PROSITEi | View protein in PROSITE PS00965, PMI_I_1, 1 hit PS00966, PMI_I_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3V100-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASPRVFPLS CVVQQYAWGK VGSKSEVACL LASSDPLAQI SEDKPYAELW
60 70 80 90 100
MGTHPRGDAK ILDNRISQKT LGQWIAENPD CLGSKVKNTF NGKLPFLFKV
110 120 130 140 150
LSVDTALSIQ AHPNKELAEK LHLQAPEHYP DANHKPEMAI ALTSFQGLCG
160 170 180 190 200
FRPVEEIVTF MKKVPEFQLL IGDDATAQLK ESVGGDTEAM ASALRNCFSH
210 220 230 240 250
LMKSEKKVVV EQLNLLVKRI SQQVFDGNNM EDIYGKLLLQ LHQQHPGDIG
260 270 280 290 300
CFAIYFLNLL TLKPGEAMFL DANVPHAYLK GDCVECMACS DNTVRAGLTP
310 320 330 340 350
KFIDVPTLCE MLNYTPSPSN NRLFAPAQSQ DDPYLSIYDP PVPDFTVMKM
360 370 380 390 400
EVPSSVTEYK VSTLDSASIL LMVQGTVTAI IPSAHAEIPL YRGGVLFIAA
410 420
NESVLLKITV PKDLLIFRAC CLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK132777 mRNA Translation: BAE21353.1 |
RefSeqi | NP_080113.1, NM_025837.2 |
Genome annotation databases
GeneIDi | 110119 |
KEGGi | mmu:110119 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK132777 mRNA Translation: BAE21353.1 |
RefSeqi | NP_080113.1, NM_025837.2 |
3D structure databases
SMRi | Q3V100 |
ModBasei | Search... |
Proteomic databases
EPDi | Q3V100 |
PeptideAtlasi | Q3V100 |
PRIDEi | Q3V100 |
Protocols and materials databases
Antibodypediai | 2008, 377 antibodies |
Genome annotation databases
GeneIDi | 110119 |
KEGGi | mmu:110119 |
Organism-specific databases
CTDi | 4351 |
MGIi | MGI:97075, Mpi |
Phylogenomic databases
HOGENOMi | CLU_026967_2_0_1 |
OMAi | CADQPLS |
OrthoDBi | 1043197at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00126;UER00423 |
Miscellaneous databases
BioGRID-ORCSi | 110119, 2 hits in 17 CRISPR screens |
ChiTaRSi | Mpi, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032306, Expressed in spermatocyte and 274 other tissues |
ExpressionAtlasi | Q3V100, baseline and differential |
Family and domain databases
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR001250, Man6P_Isoase-1 IPR016305, Mannose-6-P_Isomerase IPR018050, Pmannose_isomerase-type1_CS IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR10309, PTHR10309, 1 hit |
Pfami | View protein in Pfam PF01238, PMI_typeI, 1 hit |
PIRSFi | PIRSF001480, Mannose-6-phosphate_isomerase, 1 hit |
PRINTSi | PR00714, MAN6PISMRASE |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR00218, manA, 1 hit |
PROSITEi | View protein in PROSITE PS00965, PMI_I_1, 1 hit PS00966, PMI_I_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3V100_MOUSE | |
Accessioni | Q3V100Primary (citable) accession number: Q3V100 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |