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Protein

Transmembrane protease serine 12

Gene

Tmprss12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei110Charge relay systemBy similarity1
Active sitei159Charge relay systemBy similarity1
Active sitei256Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.958

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 12 (EC:3.4.21.-)
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1922252 Tmprss12

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 312ExtracellularSequence analysisAdd BLAST294
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 336CytoplasmicSequence analysis3

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000029043919 – 336Transmembrane protease serine 12Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi95 ↔ 111PROSITE-ProRule annotation
Disulfide bondi194 ↔ 262PROSITE-ProRule annotation
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi225 ↔ 241PROSITE-ProRule annotation
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 282PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3V0Q7
PRIDEiQ3V0Q7

PTM databases

PhosphoSitePlusiQ3V0Q7

Expressioni

Gene expression databases

BgeeiENSMUSG00000045631 Expressed in 6 organ(s), highest expression level in testis
CleanExiMM_TMPRSS12

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093914

Structurei

3D structure databases

ProteinModelPortaliQ3V0Q7
SMRiQ3V0Q7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 306Peptidase S1PROSITE-ProRule annotationAdd BLAST241

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00920000148977
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ3V0Q7
OMAiMCYLPEY
OrthoDBiEOG091G0DF7
PhylomeDBiQ3V0Q7
TreeFamiTF335943

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3V0Q7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASWALSAAL LCLGGAFAYS ELHSLSLREG SALGQATVPG PPEEEQPVTK
60 70 80 90 100
DCGIAPLRGA VEGSRIIGGS QADTGAWPWQ VSLQVQDGDI LMHVCGGALV
110 120 130 140 150
RDRWVLTAAH CTKEARDPLK WRAVMGTNDL TRSPYHSRNI RITDIIIPPD
160 170 180 190 200
FIMETFVNDI ALFRLKRAVR YNDYIQPICL PFGVFQKLDQ NTACFISGWG
210 220 230 240 250
RTREEGNGTT ILQEAKVHFI SREVCSSDQG YSGMIPNTSF CAGHENGTFD
260 270 280 290 300
SCRGDSGGPL MCYLPEHSRY FVMGITSYGH GCGRRHFPGV YSNPSFFQEW
310 320 330
MTHYLSQGNI NRLFNMDIVL GQVLTALGSV ILLGVT
Length:336
Mass (Da):36,916
Last modified:October 11, 2005 - v1
Checksum:i9398CB6A6D8EEC1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132967 mRNA Translation: BAE21447.1
CCDSiCCDS49732.1
RefSeqiNP_898932.2, NM_183109.3
UniGeneiMm.261400

Genome annotation databases

EnsembliENSMUST00000096200; ENSMUSP00000093914; ENSMUSG00000045631
GeneIDi75002
KEGGimmu:75002
UCSCiuc007xqt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132967 mRNA Translation: BAE21447.1
CCDSiCCDS49732.1
RefSeqiNP_898932.2, NM_183109.3
UniGeneiMm.261400

3D structure databases

ProteinModelPortaliQ3V0Q7
SMRiQ3V0Q7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093914

Protein family/group databases

MEROPSiS01.958

PTM databases

PhosphoSitePlusiQ3V0Q7

Proteomic databases

PaxDbiQ3V0Q7
PRIDEiQ3V0Q7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096200; ENSMUSP00000093914; ENSMUSG00000045631
GeneIDi75002
KEGGimmu:75002
UCSCiuc007xqt.1 mouse

Organism-specific databases

CTDi283471
MGIiMGI:1922252 Tmprss12

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00920000148977
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ3V0Q7
OMAiMCYLPEY
OrthoDBiEOG091G0DF7
PhylomeDBiQ3V0Q7
TreeFamiTF335943

Miscellaneous databases

PROiPR:Q3V0Q7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045631 Expressed in 6 organ(s), highest expression level in testis
CleanExiMM_TMPRSS12

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMPSC_MOUSE
AccessioniPrimary (citable) accession number: Q3V0Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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