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Protein

Leucine-rich repeat-containing protein 43

Gene

Lrrc43

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 43
Gene namesi
Name:Lrrc43
Synonyms:Gm1061
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2685907 Lrrc43

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119101 – 667Leucine-rich repeat-containing protein 43Add BLAST667

Proteomic databases

PaxDbiQ3V0L5
PRIDEiQ3V0L5

PTM databases

iPTMnetiQ3V0L5
PhosphoSitePlusiQ3V0L5

Expressioni

Gene expression databases

BgeeiENSMUSG00000063409 Expressed in 11 organ(s), highest expression level in testis
CleanExiMM_LRRC43
ExpressionAtlasiQ3V0L5 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091885

Structurei

3D structure databases

ProteinModelPortaliQ3V0L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati148 – 169LRR 1Add BLAST22
Repeati170 – 191LRR 2Add BLAST22
Repeati194 – 213LRR 3Add BLAST20
Repeati221 – 242LRR 4Add BLAST22
Domaini256 – 294LRRCTAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi557 – 560Poly-Lys4

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
ENOG410Z1ZB LUCA
GeneTreeiENSGT00390000008994
HOGENOMiHOG000113371
HOVERGENiHBG108098
InParanoidiQ3V0L5
OMAiFITYNYY
OrthoDBiEOG091G0640
PhylomeDBiQ3V0L5
TreeFamiTF330806

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3V0L5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METSESSTSD YRQTEGEGEG VPGTLSTAVC EHLRKLCLRE FPCGIGSWNK
60 70 80 90 100
SRFLPQKCRV WRELVPKEEE TLVPEEETVE ALLGLVRSNH SPWAMLKDAS
110 120 130 140 150
AEDRFLRELA IQNPLMIKDT FFYSYFRSLR VVNKGVSLVD KDLLKFLKLE
160 170 180 190 200
ELVLSANKIE EIDANNLPPT LKVLELYGNL IASMECLCSA PPPRLQHLGL
210 220 230 240 250
GHNKLLGPLE SLYVTSHNWP QLVSLDLGFN NLTDLQNMIL GLSTLRHLRL
260 270 280 290 300
LVLQGNPLSL VPYYRGFTID SLAHLCVLDD ITVSPNEKHQ FRGLNIHGDL
310 320 330 340 350
LAREAQFVVT IGNVRGVLDS SILDPEPGPD GPFISYSYYV TYDFVEDEDM
360 370 380 390 400
ERNVSGLVEA THHDSVLDEI DKHFSGTDEE DQQEDPLDGR HRHRGRQRFH
410 420 430 440 450
PGSTEEMSKE LSEFIAKEMS QMAEGSVESG ITEVDWSETS ISIHSAPLPQ
460 470 480 490 500
SIDSSEELAK LRPKIDIQLC PSPGTVLFNT VHKPWSDVIP CTYEMKHTLK
510 520 530 540 550
ELIRVKAFLL AGTTVSIVEE KILSWPVVPT PVESPLPAKK GKDNNKKKEP
560 570 580 590 600
AKDKVHKKKK EPPRELRQDP PVLTVLGSGL VYLEPLLAGE AVVSTVCNFG
610 620 630 640 650
VVRTLETDRL THARDSKKVK KSLKKDRSKT VPPTMESGYQ PEPLSVEVQI
660
QLHQYRSVEE AFLSLID
Length:667
Mass (Da):74,942
Last modified:October 11, 2005 - v1
Checksum:i12D64594105C6FD4
GO
Isoform 2 (identifier: Q3V0L5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-521: Missing.

Show »
Length:660
Mass (Da):74,157
Checksum:i6E97B1E860075D51
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGK7A0A0G2JGK7_MOUSE
Leucine-rich repeat-containing prot...
Lrrc43
657Annotation score:

Sequence cautioni

The sequence BAE39420 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029638515 – 521Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133051 mRNA Translation: BAE21489.1
AK167318 mRNA Translation: BAE39420.1 Different initiation.
AK167729 mRNA Translation: BAE39770.1
CCDSiCCDS19664.1 [Q3V0L5-1]
CCDS71662.1 [Q3V0L5-2]
RefSeqiNP_001028633.1, NM_001033461.3 [Q3V0L5-1]
NP_001276750.1, NM_001289821.1 [Q3V0L5-2]
NP_001276751.1, NM_001289822.1
UniGeneiMm.297826

Genome annotation databases

EnsembliENSMUST00000094327; ENSMUSP00000091885; ENSMUSG00000063409 [Q3V0L5-1]
ENSMUST00000121444; ENSMUSP00000113933; ENSMUSG00000063409 [Q3V0L5-2]
GeneIDi381741
KEGGimmu:381741
UCSCiuc008znu.2 mouse [Q3V0L5-1]
uc008znv.2 mouse [Q3V0L5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133051 mRNA Translation: BAE21489.1
AK167318 mRNA Translation: BAE39420.1 Different initiation.
AK167729 mRNA Translation: BAE39770.1
CCDSiCCDS19664.1 [Q3V0L5-1]
CCDS71662.1 [Q3V0L5-2]
RefSeqiNP_001028633.1, NM_001033461.3 [Q3V0L5-1]
NP_001276750.1, NM_001289821.1 [Q3V0L5-2]
NP_001276751.1, NM_001289822.1
UniGeneiMm.297826

3D structure databases

ProteinModelPortaliQ3V0L5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091885

PTM databases

iPTMnetiQ3V0L5
PhosphoSitePlusiQ3V0L5

Proteomic databases

PaxDbiQ3V0L5
PRIDEiQ3V0L5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094327; ENSMUSP00000091885; ENSMUSG00000063409 [Q3V0L5-1]
ENSMUST00000121444; ENSMUSP00000113933; ENSMUSG00000063409 [Q3V0L5-2]
GeneIDi381741
KEGGimmu:381741
UCSCiuc008znu.2 mouse [Q3V0L5-1]
uc008znv.2 mouse [Q3V0L5-2]

Organism-specific databases

CTDi254050
MGIiMGI:2685907 Lrrc43

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
ENOG410Z1ZB LUCA
GeneTreeiENSGT00390000008994
HOGENOMiHOG000113371
HOVERGENiHBG108098
InParanoidiQ3V0L5
OMAiFITYNYY
OrthoDBiEOG091G0640
PhylomeDBiQ3V0L5
TreeFamiTF330806

Miscellaneous databases

ChiTaRSiLrrc43 mouse
PROiPR:Q3V0L5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063409 Expressed in 11 organ(s), highest expression level in testis
CleanExiMM_LRRC43
ExpressionAtlasiQ3V0L5 baseline and differential

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
ProtoNetiSearch...

Entry informationi

Entry nameiLRC43_MOUSE
AccessioniPrimary (citable) accession number: Q3V0L5
Secondary accession number(s): Q3TIS6, Q3TJS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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