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UniProtKB - Q3V080 (ZN583_MOUSE)
Protein
Zinc finger protein 583
Gene
Znf583
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 211 – 233 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 239 – 261 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 267 – 289 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 295 – 317 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 323 – 345 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 351 – 373 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 379 – 401 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 407 – 429 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 435 – 457 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 463 – 485 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 491 – 513 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 519 – 541 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 583 |
Gene namesi | Name:Znf583 Synonyms:Zfp583 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2682297, Zfp583 |
VEuPathDBi | HostDB:ENSMUSG00000030443 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047675 | 1 – 568 | Zinc finger protein 583Add BLAST | 568 |
Proteomic databases
PaxDbi | Q3V080 |
PRIDEi | Q3V080 |
PTM databases
iPTMneti | Q3V080 |
PhosphoSitePlusi | Q3V080 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030443, Expressed in forelimb bud and 140 other tissues |
Genevisiblei | Q3V080, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000053935 |
Miscellaneous databases
RNActi | Q3V080, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 77 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 211 – 233 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 239 – 261 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 267 – 289 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 295 – 317 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 323 – 345 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 351 – 373 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 379 – 401 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 407 – 429 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 435 – 457 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 463 – 485 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 491 – 513 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 519 – 541 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161925 |
HOGENOMi | CLU_002678_44_3_1 |
InParanoidi | Q3V080 |
OMAi | QKRSYQK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q3V080 |
TreeFami | TF341817 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q3V080-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKNLLTFED VSVNFTQEEW QWLSDTQRDL YRKVTLENYK SLVSLGIPVY
60 70 80 90 100
KPAVISLLEQ GKDPWMVQKK GARDTCPDWQ YVFKGTEFIS KQDIYKESAK
110 120 130 140 150
VLTMGRSHFS SSLDCPDLKE DHENEDWFKN RLGRQEVHSH QLFITHKEVP
160 170 180 190 200
ESEIRGCNPS CQAVHQNAIL DVPQCSSTKE RIDQSEPQKR SYRKKSVEMK
210 220 230 240 250
HKKVQVEKRI LKCSECEKVF NQTSSLTLHQ RIHTGEKPYA CVECGKAFSQ
260 270 280 290 300
SANLAQHKRI HTGEKPYECK ECRKAFSQNA HLAQHQRVHT GEKPYQCKEC
310 320 330 340 350
KKAFSQIAHL TQHQRIHTGE RPFECIECGK AFSNGSFLAQ HQRIHTGEKP
360 370 380 390 400
YVCHVCGKAF SHRGYLIVHQ RIHTGERPYE CKECRKSFSQ YAHLSQHQRV
410 420 430 440 450
HTGEKPYECK VCRKAFSQVA YLDQHQRVHT GEKPYECAEC RKAFSNSSSL
460 470 480 490 500
AQHQRSHTGE KPYICKECRK TFSQNAGLAQ HQRIHTGEKP YECNICGKAF
510 520 530 540 550
SYSGSLTLHQ RIHTGERPYE CKDCRKSFRQ RAHLAHHEKV HTMESFLSLS
560
SPSPSMSSQL PRTLGLIS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3YXW6 | D3YXW6_MOUSE | Zinc finger protein 583 | Zfp583 | 76 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK038614 mRNA Translation: BAE20539.1 AK133380 mRNA Translation: BAE21624.1 |
CCDSi | CCDS39751.1 |
RefSeqi | NP_001028421.1, NM_001033249.3 XP_011248777.1, XM_011250475.2 |
Genome annotation databases
Ensembli | ENSMUST00000062765; ENSMUSP00000053935; ENSMUSG00000030443 ENSMUST00000108560; ENSMUSP00000104200; ENSMUSG00000030443 ENSMUST00000165705; ENSMUSP00000129551; ENSMUSG00000030443 |
GeneIDi | 213011 |
KEGGi | mmu:213011 |
UCSCi | uc009fbc.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK038614 mRNA Translation: BAE20539.1 AK133380 mRNA Translation: BAE21624.1 |
CCDSi | CCDS39751.1 |
RefSeqi | NP_001028421.1, NM_001033249.3 XP_011248777.1, XM_011250475.2 |
3D structure databases
SMRi | Q3V080 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000053935 |
PTM databases
iPTMneti | Q3V080 |
PhosphoSitePlusi | Q3V080 |
Proteomic databases
PaxDbi | Q3V080 |
PRIDEi | Q3V080 |
Protocols and materials databases
Antibodypediai | 33209, 111 antibodies from 18 providers |
Genome annotation databases
Ensembli | ENSMUST00000062765; ENSMUSP00000053935; ENSMUSG00000030443 ENSMUST00000108560; ENSMUSP00000104200; ENSMUSG00000030443 ENSMUST00000165705; ENSMUSP00000129551; ENSMUSG00000030443 |
GeneIDi | 213011 |
KEGGi | mmu:213011 |
UCSCi | uc009fbc.2, mouse |
Organism-specific databases
CTDi | 213011 |
MGIi | MGI:2682297, Zfp583 |
VEuPathDBi | HostDB:ENSMUSG00000030443 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161925 |
HOGENOMi | CLU_002678_44_3_1 |
InParanoidi | Q3V080 |
OMAi | QKRSYQK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q3V080 |
TreeFami | TF341817 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 213011, 0 hits in 64 CRISPR screens |
PROi | PR:Q3V080 |
RNActi | Q3V080, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030443, Expressed in forelimb bud and 140 other tissues |
Genevisiblei | Q3V080, MM |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN583_MOUSE | |
Accessioni | Q3V080Primary (citable) accession number: Q3V080 Secondary accession number(s): Q3V3L4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families