Znf583

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	211 – 233	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	239 – 261	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	267 – 289	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	295 – 317	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	323 – 345	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	351 – 373	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	379 – 401	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	407 – 429	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	435 – 457	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	463 – 485	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	491 – 513	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	519 – 541	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 583
Gene namesⁱ	Name:Znf583 Synonyms:Zfp583
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:2682297 Zfp583

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047675	1 – 568	Zinc finger protein 583Add BLAST		568

Proteomic databases

PaxDbⁱ	Q3V080
PRIDEⁱ	Q3V080

PTM databases

iPTMnetⁱ	Q3V080
PhosphoSitePlusⁱ	Q3V080

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030443 Expressed in 93 organ(s), highest expression level in oocyte
CleanExⁱ	MM_ZFP583
ExpressionAtlasⁱ	Q3V080 baseline and differential
Genevisibleⁱ	Q3V080 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000053935

STRINGⁱ

10090.ENSMUSP00000053935

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3V080
SMRⁱ	Q3V080
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 77	KRABPROSITE-ProRule annotationAdd BLAST		72

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	211 – 233	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	239 – 261	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	267 – 289	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	295 – 317	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	323 – 345	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	351 – 373	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	379 – 401	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	407 – 429	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	435 – 457	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	463 – 485	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	491 – 513	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	519 – 541	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129704
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q3V080
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	RGYLIVH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q3V080
TreeFamⁱ	TF341817

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 12 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 12 hits PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q3V080-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKNLLTFED VSVNFTQEEW QWLSDTQRDL YRKVTLENYK SLVSLGIPVY 
        60         70         80         90        100
KPAVISLLEQ GKDPWMVQKK GARDTCPDWQ YVFKGTEFIS KQDIYKESAK 
       110        120        130        140        150
VLTMGRSHFS SSLDCPDLKE DHENEDWFKN RLGRQEVHSH QLFITHKEVP 
       160        170        180        190        200
ESEIRGCNPS CQAVHQNAIL DVPQCSSTKE RIDQSEPQKR SYRKKSVEMK 
       210        220        230        240        250
HKKVQVEKRI LKCSECEKVF NQTSSLTLHQ RIHTGEKPYA CVECGKAFSQ 
       260        270        280        290        300
SANLAQHKRI HTGEKPYECK ECRKAFSQNA HLAQHQRVHT GEKPYQCKEC 
       310        320        330        340        350
KKAFSQIAHL TQHQRIHTGE RPFECIECGK AFSNGSFLAQ HQRIHTGEKP 
       360        370        380        390        400
YVCHVCGKAF SHRGYLIVHQ RIHTGERPYE CKECRKSFSQ YAHLSQHQRV 
       410        420        430        440        450
HTGEKPYECK VCRKAFSQVA YLDQHQRVHT GEKPYECAEC RKAFSNSSSL 
       460        470        480        490        500
AQHQRSHTGE KPYICKECRK TFSQNAGLAQ HQRIHTGEKP YECNICGKAF 
       510        520        530        540        550
SYSGSLTLHQ RIHTGERPYE CKDCRKSFRQ RAHLAHHEKV HTMESFLSLS 
       560 
SPSPSMSSQL PRTLGLIS

Length:568

Mass (Da):65,709

Last modified:October 11, 2005 - v1

Checksum:ⁱ32640CB4CBEDA2E5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3YXW6	D3YXW6_MOUSE		Zinc finger protein 583 Zinc finger protein 583	Zfp583	76	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK038614 mRNA Translation: BAE20539.1 AK133380 mRNA Translation: BAE21624.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39751.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001028421.1, NM_001033249.3 XP_011248777.1, XM_011250475.2
UniGeneⁱ	Mm.333558

Genome annotation databases

Ensemblⁱ	ENSMUST00000062765; ENSMUSP00000053935; ENSMUSG00000030443 ENSMUST00000108560; ENSMUSP00000104200; ENSMUSG00000030443 ENSMUST00000165705; ENSMUSP00000129551; ENSMUSG00000030443
GeneIDⁱ	213011
KEGGⁱ	mmu:213011
UCSC genome browser More...UCSCⁱ	uc009fbc.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3V080	Zinc finger protein 583 (Fragment)		MOUSE		76	UniRef100_Q3V080

Protein	Similar proteins		Species	Score	Length	Source
Q3V080	Zinc finger protein 583 (Fragment)		MOUSE		76	UniRef90_Q3V080
Zinc finger protein 583		RAT		568
UPI000A308C09		MUSPA		568
UPI000A3175EF		MUSCR		568
Zfp583 protein (Fragment)		MOUSE		570
+6

Protein	Similar proteins		Species	Score	Length	Source
Q3V080	Zinc finger protein 583		HUMAN		569	UniRef50_Q96ND8
ZNF583 isoform 6 (Fragment)		PANTR		137
Uncharacterized protein		FELCA		572
zinc finger protein 583 isoform X1		LIPVE		570
zinc finger protein 583 isoform X1		Yangtze finless porpoise		570
+387

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK038614 mRNA Translation: BAE20539.1 AK133380 mRNA Translation: BAE21624.1
CCDSⁱ	CCDS39751.1
RefSeqⁱ	NP_001028421.1, NM_001033249.3 XP_011248777.1, XM_011250475.2
UniGeneⁱ	Mm.333558

3D structure databases

ProteinModelPortalⁱ	Q3V080
SMRⁱ	Q3V080
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000053935

STRINGⁱ

10090.ENSMUSP00000053935

PTM databases

iPTMnetⁱ	Q3V080
PhosphoSitePlusⁱ	Q3V080

Proteomic databases

PaxDbⁱ	Q3V080
PRIDEⁱ	Q3V080

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000062765; ENSMUSP00000053935; ENSMUSG00000030443 ENSMUST00000108560; ENSMUSP00000104200; ENSMUSG00000030443 ENSMUST00000165705; ENSMUSP00000129551; ENSMUSG00000030443
GeneIDⁱ	213011
KEGGⁱ	mmu:213011
UCSCⁱ	uc009fbc.2 mouse

Organism-specific databases

CTDⁱ	213011
MGIⁱ	MGI:2682297 Zfp583

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00840000129704
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q3V080
KOⁱ	K09228
OMAⁱ	RGYLIVH
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q3V080
TreeFamⁱ	TF341817

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3V080
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030443 Expressed in 93 organ(s), highest expression level in oocyte
CleanExⁱ	MM_ZFP583
ExpressionAtlasⁱ	Q3V080 baseline and differential
Genevisibleⁱ	Q3V080 MM

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 12 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 12 hits PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN583_MOUSE
Accessionⁱ	Q3V080Primary (citable) accession number: Q3V080 Secondary accession number(s): Q3V3L4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	October 11, 2005
	Last modified:	October 10, 2018
	This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3V080 (ZN583_MOUSE)

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Zinc finger protein 583

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ