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Entry version 107 (12 Aug 2020)
Sequence version 1 (11 Oct 2005)
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Protein

Multidrug and toxin extrusion protein 2

Gene

Slc47a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Solute transporter for tetraethylammonium (TEA), cimetidine, choline, procainamide, cimetidine, quinidine, guanidine, N-methylnicotinamide (NMN). Responsible for the secretion of cationic drugs across the brush border membranes.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.710 mM for TEA1 Publication
  1. Vmax=0.004 nmol/min/mg enzyme toward TEA1 Publication

pH dependencei

Optimum pH is 8.5. Active from pH 6 to 8.5.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.66.1.16, the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 2
Short name:
MATE-2
Short name:
mMATE-2
Alternative name(s):
H(+)/organic cation antiporter kidney-specific
Solute carrier family 47 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc47a2
Synonyms:Mate2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3588190, Slc47a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 46CytoplasmicSequence analysisAdd BLAST46
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 81ExtracellularSequence analysisAdd BLAST14
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 122CytoplasmicSequence analysisAdd BLAST20
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 161ExtracellularSequence analysisAdd BLAST18
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 196CytoplasmicSequence analysisAdd BLAST14
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 225ExtracellularSequence analysis8
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 266CytoplasmicSequence analysisAdd BLAST20
Transmembranei267 – 286HelicalSequence analysisAdd BLAST20
Topological domaini287 – 304ExtracellularSequence analysisAdd BLAST18
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 345CytoplasmicSequence analysisAdd BLAST20
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 379ExtracellularSequence analysisAdd BLAST13
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 415CytoplasmicSequence analysisAdd BLAST15
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 443ExtracellularSequence analysis7
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 545CytoplasmicSequence analysisAdd BLAST81
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 573ExtracellularSequence analysis7

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

DrugCentral

More...
DrugCentrali
Q3V050

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1217

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003128521 – 573Multidrug and toxin extrusion protein 2Add BLAST573

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3V050

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3V050

PRoteomics IDEntifications database

More...
PRIDEi
Q3V050

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis; especially in testicular Leydig cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000069855, Expressed in spermatocyte and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3V050, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000090710

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3V050, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3V050

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1347, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163327

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3V050

KEGG Orthology (KO)

More...
KOi
K03327

Database of Orthologous Groups

More...
OrthoDBi
743037at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3V050

TreeFam database of animal gene trees

More...
TreeFami
TF324441

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002528, MATE_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01554, MatE, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00797, matE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3V050-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPAEDSLGA TIQPPELVRV PRGRSLRILL GLRGALSPDV RREAAALVAL
60 70 80 90 100
AGPVFLAQLM IFLISIVSSI FCGHLGKVEL DAVTLAVSVV NVTGISVGTG
110 120 130 140 150
LASACDTLMS QSFGGKNLKR VGVILQRGIL ILLLCCFPCW AIFLNTERLL
160 170 180 190 200
LLLRQDPDVA RLAQVYVMIC IPALPAAFLF QLQTRYLQSQ GIIMPQVIVG
210 220 230 240 250
IAANVVNVGM NAFLLYALDL GVVGSAWANT TSQFFLSALL FLYVWWKRIH
260 270 280 290 300
IHTWGGWTRE CFQEWSSYTR LAIPSMFMVC IEWWTFEIGT FLAGLVNVTE
310 320 330 340 350
LGAQAVIYEL ASVAYMVPFG FGVAASVRVG NALGAGNADQ ARCSCTTVLL
360 370 380 390 400
CAGVCALLVG ILLAALKDVV AYIFTNDKDI ISLVSQVMPI FAPFHLFDAL
410 420 430 440 450
AGTCGGVLRG TGKQKIGAVL NTIGYYGFGF PIGVSLMFAA KLGIIGLWAG
460 470 480 490 500
LIVCVSFQAF SYLIYILRTN WSRVAEQAQV RAGLKSTKEL IPTPADLPIL
510 520 530 540 550
EREVMDGVIL PDIIRPESQT GQLVVEENSQ CAVPTVGEVL TGRQLVFYRG
560 570
MALTVSVAVL IAGIVVRVFN DRG
Length:573
Mass (Da):61,789
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB18968B12E84F805
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YMV2Z4YMV2_MOUSE
Multidrug and toxin extrusion prote...
Slc47a2
477Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI25733 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK133432 mRNA Translation: BAE21655.1
AL669884 Genomic DNA Translation: CAI25733.1 Sequence problems.
BC147619 mRNA Translation: AAI47620.1
BC157913 mRNA Translation: AAI57914.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24810.1

NCBI Reference Sequences

More...
RefSeqi
NP_001028714.1, NM_001033542.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093029; ENSMUSP00000090710; ENSMUSG00000069855

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
380701

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:380701

UCSC genome browser

More...
UCSCi
uc007jhg.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133432 mRNA Translation: BAE21655.1
AL669884 Genomic DNA Translation: CAI25733.1 Sequence problems.
BC147619 mRNA Translation: AAI47620.1
BC157913 mRNA Translation: AAI57914.1
CCDSiCCDS24810.1
RefSeqiNP_001028714.1, NM_001033542.2

3D structure databases

SMRiQ3V050
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090710

Chemistry databases

DrugCentraliQ3V050
GuidetoPHARMACOLOGYi1217

Protein family/group databases

TCDBi2.A.66.1.16, the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

Proteomic databases

jPOSTiQ3V050
PaxDbiQ3V050
PRIDEiQ3V050

Genome annotation databases

EnsembliENSMUST00000093029; ENSMUSP00000090710; ENSMUSG00000069855
GeneIDi380701
KEGGimmu:380701
UCSCiuc007jhg.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
146802
MGIiMGI:3588190, Slc47a2

Phylogenomic databases

eggNOGiKOG1347, Eukaryota
GeneTreeiENSGT00940000163327
InParanoidiQ3V050
KOiK03327
OrthoDBi743037at2759
PhylomeDBiQ3V050
TreeFamiTF324441

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
380701, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Slc47a2, mouse

Protein Ontology

More...
PROi
PR:Q3V050
RNActiQ3V050, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000069855, Expressed in spermatocyte and 37 other tissues
ExpressionAtlasiQ3V050, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002528, MATE_fam
PfamiView protein in Pfam
PF01554, MatE, 2 hits
TIGRFAMsiTIGR00797, matE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS47A2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3V050
Secondary accession number(s): B2RXN1, Q5SS46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 11, 2005
Last modified: August 12, 2020
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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