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Entry version 85 (02 Jun 2021)
Sequence version 1 (11 Oct 2005)
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Protein

Coiled-coil domain-containing protein 27

Gene

Ccdc27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 27
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccdc27
Synonyms:Gm1035
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685881, Ccdc27

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002340211 – 639Coiled-coil domain-containing protein 27Add BLAST639

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3V036

PRoteomics IDEntifications database

More...
PRIDEi
Q3V036

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
281304

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3V036

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3V036

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039492, Expressed in testis and 57 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3V036, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
237998, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q3V036

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039642

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3V036, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3V036

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni154 – 176DisorderedSequence analysisAdd BLAST23
Regioni291 – 385DisorderedSequence analysisAdd BLAST95

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili203 – 242Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi160 – 176Polar residuesSequence analysisAdd BLAST17
Compositional biasi291 – 313Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi335 – 354Acidic residuesSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RXSM, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154171

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025625_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3V036

Identification of Orthologs from Complete Genome Data

More...
OMAi
MRPGCPQ

Database of Orthologous Groups

More...
OrthoDBi
814498at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3V036

TreeFam database of animal gene trees

More...
TreeFami
TF335685

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3V036-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQENLTQEC CSTSPKISKG LMVLQSIASR GCDTQDSEKK PQSTQQSLKK
60 70 80 90 100
SSQAAAGYFY DKEDQIRKLS KHNGFLSEME DMRKAFLMRP GCPQFSTRTT
110 120 130 140 150
SMSHVGSAIM VDLPRTCSGV WKLTEDHPLG RLGSASSVDG RVFPFSKSAC
160 170 180 190 200
ELNYPRKRSE PSDPSPTGSP TVVKKSQRTR TPWYISVIHE KDHSLLLMGE
210 220 230 240 250
ELQRFSEMES QMQKKDQEIL TLQKEKEALK KQLKNLLRGK GTETSSASIK
260 270 280 290 300
MDRSFETPLK LGRMSVLKTI YKEEDELQHW MQMQEEYSMA ESSKELHVEP
310 320 330 340 350
GSAIEEKSSE GPPEEAAAAK LSRPSQSKTE TLLEVGPEEE EEEEEEEVEG
360 370 380 390 400
DEAKGTEEGE ILVNEEEASW ELREDEECHP KRSYSMTESF EEELMAQLEE
410 420 430 440 450
YERMLMDFQR ELEFTRSRYS LATGTITSLQ RQTDFQESQL RKVTTENELL
460 470 480 490 500
EKELRERKQQ IQDMTDKFSN LREEKKHQEI MGLIEKENLV LRQQVADLKM
510 520 530 540 550
DLISSERTIK ELNTQTKELE DQVNTDKDHL RRWKDLHDDL QTRNEIIQQT
560 570 580 590 600
EQQTRVVLEA TQARYEKLRN KIIQAVFSVS GNKNLSMELS DSYILESLQR
610 620 630
IISERSDFYS QLKQKGVKVP PLQQSDVSLP SKIKKMASK
Length:639
Mass (Da):73,651
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3F525B3C5936206
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK133459 mRNA Translation: BAE21669.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19008.1

NCBI Reference Sequences

More...
RefSeqi
NP_001028627.1, NM_001033455.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000047207; ENSMUSP00000039642; ENSMUSG00000039492

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
381580

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:381580

UCSC genome browser

More...
UCSCi
uc008wbf.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133459 mRNA Translation: BAE21669.1
CCDSiCCDS19008.1
RefSeqiNP_001028627.1, NM_001033455.2

3D structure databases

SMRiQ3V036
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi237998, 1 interactor
CORUMiQ3V036
STRINGi10090.ENSMUSP00000039642

PTM databases

iPTMnetiQ3V036
PhosphoSitePlusiQ3V036

Proteomic databases

PaxDbiQ3V036
PRIDEiQ3V036
ProteomicsDBi281304

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
52630, 37 antibodies

Genome annotation databases

EnsembliENSMUST00000047207; ENSMUSP00000039642; ENSMUSG00000039492
GeneIDi381580
KEGGimmu:381580
UCSCiuc008wbf.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
148870
MGIiMGI:2685881, Ccdc27

Phylogenomic databases

eggNOGiENOG502RXSM, Eukaryota
GeneTreeiENSGT00940000154171
HOGENOMiCLU_025625_0_0_1
InParanoidiQ3V036
OMAiMRPGCPQ
OrthoDBi814498at2759
PhylomeDBiQ3V036
TreeFamiTF335685

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
381580, 0 hits in 52 CRISPR screens

Protein Ontology

More...
PROi
PR:Q3V036
RNActiQ3V036, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039492, Expressed in testis and 57 other tissues
ExpressionAtlasiQ3V036, baseline and differential

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD27_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3V036
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 11, 2005
Last modified: June 2, 2021
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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