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Protein

Transmembrane emp24 domain-containing protein 1

Gene

Tmed1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.By similarity

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • Golgi organization Source: GO_Central
  • intracellular protein transport Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 1
Alternative name(s):
Interleukin-1 receptor-like 1 ligand
Putative T1/ST2 receptor-binding protein
p24 family protein gamma-1
Short name:
p24gamma1
Gene namesi
Name:Tmed1
Synonyms:Il1rl1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:106201 Tmed1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 194ExtracellularSequence analysisAdd BLAST170
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 227CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000024802025 – 227Transmembrane emp24 domain-containing protein 1Add BLAST203

Proteomic databases

PaxDbiQ3V009
PeptideAtlasiQ3V009
PRIDEiQ3V009

PTM databases

PhosphoSitePlusiQ3V009
SwissPalmiQ3V009

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000032180 Expressed in 237 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_TMED1
ExpressionAtlasiQ3V009 baseline and differential
GenevisibleiQ3V009 MM

Interactioni

Subunit structurei

Homodimer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. May interact with IL1RL1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ3V009, 1 interactor
STRINGi10090.ENSMUSP00000034698

Structurei

3D structure databases

SMRiQ3V009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 125GOLDPROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili145 – 170Sequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi218 – 227COPI vesicle coat-bindingSequence analysis10
Motifi218 – 219COPII vesicle coat-bindingSequence analysis2

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3287 Eukaryota
ENOG410Z18S LUCA
GeneTreeiENSGT00670000097656
HOGENOMiHOG000039809
HOVERGENiHBG000271
InParanoidiQ3V009
KOiK20348
OMAiRSRQMQT
OrthoDBiEOG091G0RNG
PhylomeDBiQ3V009
TreeFamiTF313000

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3V009-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAAGAAVAL ALWLLLPAVG VGEAGPPPIQ DGEFTFLLPA GRKQCFYQSA
60 70 80 90 100
PANASLETEY QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA
110 120 130 140 150
GDYRLCFDNS FSTISEKLVF FELIFDSFQD EEEVEGWAEA VEPEEMLDVK
160 170 180 190 200
MEDIKESIET MRTRLERSIQ MLTLLRAFEA RDRNLQEDNL ERVNFWSAAN
210 220
VAVLLLVAVL QVCTLKRFFH DKRPVPT
Length:227
Mass (Da):25,263
Last modified:October 11, 2005 - v1
Checksum:iF37FC38E54AB4495
GO
Isoform 2 (identifier: Q3V009-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     86-94: SRKADGVHT → MLVLRPSTR

Show »
Length:142
Mass (Da):16,635
Checksum:i859CA05B4CBEDC4E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1STZ6A0A1L1STZ6_MOUSE
Transmembrane emp24 domain-containi...
Tmed1
129Annotation score:
A0A1L1ST36A0A1L1ST36_MOUSE
Transmembrane emp24 domain-containi...
Tmed1
86Annotation score:
A0A1L1SU69A0A1L1SU69_MOUSE
Transmembrane emp24 domain-containi...
Tmed1
65Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0201351 – 85Missing in isoform 2. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_02013686 – 94SRKADGVHT → MLVLRPSTR in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133513 mRNA Translation: BAE21696.1
AK160525 mRNA Translation: BAE35843.1
U41805 mRNA Translation: AAC52472.1
CCDSiCCDS22904.1 [Q3V009-1]
RefSeqiNP_001311439.1, NM_001324510.1
NP_034874.2, NM_010744.4 [Q3V009-1]
UniGeneiMm.196618

Genome annotation databases

EnsembliENSMUST00000034698; ENSMUSP00000034698; ENSMUSG00000032180 [Q3V009-1]
GeneIDi17083
KEGGimmu:17083
UCSCiuc009olp.1 mouse [Q3V009-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133513 mRNA Translation: BAE21696.1
AK160525 mRNA Translation: BAE35843.1
U41805 mRNA Translation: AAC52472.1
CCDSiCCDS22904.1 [Q3V009-1]
RefSeqiNP_001311439.1, NM_001324510.1
NP_034874.2, NM_010744.4 [Q3V009-1]
UniGeneiMm.196618

3D structure databases

SMRiQ3V009
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3V009, 1 interactor
STRINGi10090.ENSMUSP00000034698

PTM databases

PhosphoSitePlusiQ3V009
SwissPalmiQ3V009

Proteomic databases

PaxDbiQ3V009
PeptideAtlasiQ3V009
PRIDEiQ3V009

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034698; ENSMUSP00000034698; ENSMUSG00000032180 [Q3V009-1]
GeneIDi17083
KEGGimmu:17083
UCSCiuc009olp.1 mouse [Q3V009-1]

Organism-specific databases

CTDi11018
MGIiMGI:106201 Tmed1

Phylogenomic databases

eggNOGiKOG3287 Eukaryota
ENOG410Z18S LUCA
GeneTreeiENSGT00670000097656
HOGENOMiHOG000039809
HOVERGENiHBG000271
InParanoidiQ3V009
KOiK20348
OMAiRSRQMQT
OrthoDBiEOG091G0RNG
PhylomeDBiQ3V009
TreeFamiTF313000

Miscellaneous databases

PROiPR:Q3V009
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032180 Expressed in 237 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_TMED1
ExpressionAtlasiQ3V009 baseline and differential
GenevisibleiQ3V009 MM

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMED1_MOUSE
AccessioniPrimary (citable) accession number: Q3V009
Secondary accession number(s): Q3TUX8, Q61073, Q91YK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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