UniProtKB - Q3UZZ2 (Q3UZZ2_MOUSE)
Protein
Submitted name:
Uncharacterized protein
Gene
Hes1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- histone deacetylase binding Source: Ensembl
- protein dimerization activity Source: InterPro
- sequence-specific double-stranded DNA binding Source: Ensembl
GO - Biological processi
- negative regulation of pro-B cell differentiation Source: Ensembl
- negative regulation of stem cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neuronal stem cell population maintenance Source: Ensembl
- Notch signaling pathway Source: Ensembl
Keywordsi
Molecular function | RepressorARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:Hes1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:104853, Hes1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022528, Expressed in lens of camera-type eye and 302 other tissues |
ExpressionAtlasi | Q3UZZ2, baseline and differential |
Genevisiblei | Q3UZZ2, MM |
Interactioni
GO - Molecular functioni
- histone deacetylase binding Source: Ensembl
- protein dimerization activity Source: InterPro
Chemistry databases
BindingDBi | Q3UZZ2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 91 | BHLHInterPro annotationAdd BLAST | 58 | |
Domaini | 110 – 143 | OrangeInterPro annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 44 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 158 – 204 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 256 – 282 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 27 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 28 – 44 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 161 – 200 | Pro-richSequence analysisAdd BLAST | 40 |
Phylogenomic databases
HOGENOMi | CLU_068550_1_0_1 |
OMAi | MNAVSCK |
OrthoDBi | 1427802at2759 |
PhylomeDBi | Q3UZZ2 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UZZ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPADIMEKNS SSPVAATPAS VNTTPDKPKT ASEHRKSSKP IMEKRRRARI
60 70 80 90 100
NESLSQLKTL ILDALKKDSS RHSKLEKADI LEMTVKHLRN LQRAQMTAAL
110 120 130 140 150
STDPSVLGKY RAGFSECMNE VTRFLSTCEG VNTEVRTRLL GHLANCMTQI
160 170 180 190 200
NAMTYPGQAH PALQAPPPPP PSGPAGPQHA PFAPPPPPLV PIPGGAAPPP
210 220 230 240 250
GSAPCKLGSQ AGEAAKVFGG FQVVPAPDGQ FAFLIPNGAF AHSGPVIPVY
260 270 280
TSNSGTSVGP NAVSPSSGSS LTSDSMWRPW RN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK133538 mRNA Translation: BAE21713.1 |
RefSeqi | NP_032261.1, NM_008235.2 |
Genome annotation databases
GeneIDi | 15205 |
KEGGi | mmu:15205 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK133538 mRNA Translation: BAE21713.1 |
RefSeqi | NP_032261.1, NM_008235.2 |
3D structure databases
SMRi | Q3UZZ2 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q3UZZ2 |
Proteomic databases
MaxQBi | Q3UZZ2 |
Protocols and materials databases
Antibodypediai | 19442, 621 antibodies |
DNASUi | 15205 |
Genome annotation databases
GeneIDi | 15205 |
KEGGi | mmu:15205 |
Organism-specific databases
CTDi | 3280 |
MGIi | MGI:104853, Hes1 |
Phylogenomic databases
HOGENOMi | CLU_068550_1_0_1 |
OMAi | MNAVSCK |
OrthoDBi | 1427802at2759 |
PhylomeDBi | Q3UZZ2 |
Miscellaneous databases
BioGRID-ORCSi | 15205, 1 hit in 52 CRISPR screens |
ChiTaRSi | Hes1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022528, Expressed in lens of camera-type eye and 302 other tissues |
ExpressionAtlasi | Q3UZZ2, baseline and differential |
Genevisiblei | Q3UZZ2, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UZZ2_MOUSE | |
Accessioni | Q3UZZ2Primary (citable) accession number: Q3UZZ2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | April 7, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |