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Protein

MARVEL domain-containing protein 2

Gene

Marveld2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing.1 Publication

GO - Biological processi

Keywordsi

Biological processHearing

Names & Taxonomyi

Protein namesi
Recommended name:
MARVEL domain-containing protein 2
Alternative name(s):
Tricellulin
Gene namesi
Name:Marveld2
Synonyms:Mrvldc2, Tric
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2446166 Marveld2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 191CytoplasmicSequence analysisAdd BLAST191
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 251ExtracellularSequence analysisAdd BLAST39
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 288CytoplasmicSequence analysisAdd BLAST16
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 338ExtracellularSequence analysisAdd BLAST29
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 555CytoplasmicSequence analysisAdd BLAST196

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002715271 – 555MARVEL domain-containing protein 2Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei158PhosphoserineBy similarity1
Modified residuei163PhosphothreonineBy similarity1
Modified residuei384PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UZP0
PaxDbiQ3UZP0
PRIDEiQ3UZP0

PTM databases

iPTMnetiQ3UZP0
PhosphoSitePlusiQ3UZP0

Expressioni

Tissue specificityi

Predominantly localized to small intestine, stomach and kidney, in epithelial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000021636 Expressed in 172 organ(s), highest expression level in cochlea
CleanExiMM_MARVELD2
ExpressionAtlasiQ3UZP0 baseline and differential
GenevisibleiQ3UZP0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022137

Structurei

3D structure databases

ProteinModelPortaliQ3UZP0
SMRiQ3UZP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 364MARVELPROSITE-ProRule annotationAdd BLAST180

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili521 – 545Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 53Poly-Pro8

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4796 Eukaryota
ENOG410ZNGU LUCA
GeneTreeiENSGT00550000074378
HOGENOMiHOG000155323
HOVERGENiHBG079727
InParanoidiQ3UZP0
KOiK17291
OMAiVNFKELR
OrthoDBiEOG091G04ZP
PhylomeDBiQ3UZP0
TreeFamiTF326161

Family and domain databases

InterProiView protein in InterPro
IPR031176 ELL/occludin
IPR008253 Marvel
IPR031177 MARVELD2
IPR010844 Occludin_ELL
PANTHERiPTHR23288 PTHR23288, 1 hit
PTHR23288:SF3 PTHR23288:SF3, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PF07303 Occludin_ELL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q3UZP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSDARSRI RDRGYSEVPR DTSCPDGTIR TFQSLHSSEL AVSADPLPPP
60 70 80 90 100
PLPLQPPFGP SFYSSDTEEP AVAPDLKPVR RFVPDSWKNF FRGKKKDPEW
110 120 130 140 150
DNPVSDIRYI SDGVECSPPA SPARANHHPY KDPSRGSQGT FNSQHEADAM
160 170 180 190 200
FAHDPYASLD RRTQTARTYS EKVEEYNLRY AYMKSWAGLL RILGVVELLL
210 220 230 240 250
GAGVFACVTA YIHKDNEWYN LFGYTQPYGM GGLGSLGNTY GGYYYSGPKT
260 270 280 290 300
PFVLVVAGLA WITTIIILVL GMSMYYRTIL LDSNWWPLTE FGVNVALFIL
310 320 330 340 350
YMAAAIVYVN DTNRGGLCYY PLFNTPMNAM FCRVEGGQIA AMIFLFVTMI
360 370 380 390 400
VYLVSALVCL KLWRHEAARR HREFLEQQEI NDPSLSSKRK MCEAAISDRQ
410 420 430 440 450
RDQEVNVKDL RTTTKMTPEL LSGHIPPGHI PKPIVMPDYV AKYPVIQTDD
460 470 480 490 500
DRERYKAVFQ DQFSEYKELS AEVQAILRKF DELDTVMSRL PHHSENRQEH
510 520 530 540 550
ERISRIHEEF RKKKNDPSFL EKKERCDYLK NKLSHIKQRI QEYDKVMNWD

TQGYP
Length:555
Mass (Da):63,662
Last modified:October 11, 2005 - v1
Checksum:iCF91270F47D4DDD5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q1T5E9Q1T5_MOUSE
MARVEL domain-containing protein 2
Marveld2
278Annotation score:

Sequence cautioni

The sequence AAH49919 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120 – 131ASPAR…HHPYK → TRPPTRPPTRP in AAH03296 (PubMed:15489334).CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219935 mRNA Translation: BAE54512.1
DQ143929 mRNA Translation: ABA18656.1
AK133741 mRNA Translation: BAE21816.1
BC003296 mRNA Translation: AAH03296.1
BC049919 mRNA Translation: AAH49919.1 Different initiation.
CCDSiCCDS26732.1
RefSeqiNP_001033691.1, NM_001038602.4
XP_006517668.1, XM_006517605.1
UniGeneiMm.25300

Genome annotation databases

EnsembliENSMUST00000022137; ENSMUSP00000022137; ENSMUSG00000021636
ENSMUST00000168772; ENSMUSP00000126438; ENSMUSG00000021636
ENSMUST00000225754; ENSMUSP00000153294; ENSMUSG00000021636
GeneIDi218518
KEGGimmu:218518
UCSCiuc007rra.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMALD2_MOUSE
AccessioniPrimary (citable) accession number: Q3UZP0
Secondary accession number(s): Q80UJ4, Q99LE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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