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Protein

CapZ-interacting protein

Gene

Rcsd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CapZ-interacting protein
Alternative name(s):
Protein kinase substrate CapZIP
Gene namesi
Name:Rcsd1
Synonyms:Capzip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2676394 Rcsd1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003202631 – 412CapZ-interacting proteinAdd BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68PhosphoserineBy similarity1
Modified residuei82PhosphoserineBy similarity1
Modified residuei83PhosphoserineBy similarity1
Modified residuei105PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei123PhosphoserineCombined sources1
Modified residuei124PhosphothreonineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei135PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei177PhosphoserineBy similarity1
Modified residuei179PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei243PhosphothreonineCombined sources1
Modified residuei256PhosphothreonineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei401PhosphoserineCombined sources1

Post-translational modificationi

Dephosphorylation results in its dissociation from CAPZA2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UZA1
PaxDbiQ3UZA1
PeptideAtlasiQ3UZA1
PRIDEiQ3UZA1

PTM databases

iPTMnetiQ3UZA1
PhosphoSitePlusiQ3UZA1

Expressioni

Gene expression databases

BgeeiENSMUSG00000040723 Expressed in 243 organ(s), highest expression level in thymus
CleanExiMM_RCSD1
ExpressionAtlasiQ3UZA1 baseline and differential
GenevisibleiQ3UZA1 MM

Interactioni

Subunit structurei

Interacts with CAPZA2 and CAPZB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230536, 2 interactors
STRINGi10090.ENSMUSP00000043724

Structurei

3D structure databases

ProteinModelPortaliQ3UZA1
SMRiQ3UZA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKAV Eukaryota
ENOG410YWC5 LUCA
GeneTreeiENSGT00510000049038
HOGENOMiHOG000049036
HOVERGENiHBG106582
InParanoidiQ3UZA1
KOiK18615
OMAiKETPACK
OrthoDBiEOG091G0DQJ
PhylomeDBiQ3UZA1
TreeFamiTF334159

Family and domain databases

InterProiView protein in InterPro
IPR029341 FAM21/CAPZIP
IPR007850 RCSD
PfamiView protein in Pfam
PF15255 CAP-ZIP_m, 1 hit
PF05177 RCSD, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UZA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEERPSETNS NVDSSAQPSV AQLAGRFREH AAVARETPAS KPTRRKPPCS
60 70 80 90 100
LPLFPPKVEL GQNGEEKSPS GASHPPKIKV KSSPLIEKLQ ANLAFDPAAL
110 120 130 140 150
LPGASPKSPG LKAIVSPFHS PPSTPSSPGI RSHPSEAEEV PVSFDQPPEG
160 170 180 190 200
THLPSYNKVR TRGSIKRRPP SRRFRRSQSD CGDFRDYRAV EPSQENGARE
210 220 230 240 250
ENGDDVFASK SKDPGSPQLN QEAMADGVEG TPWSAEKPRR RNTCNSTEKP
260 270 280 290 300
EELVRTPEEA NAGEKVGQNP DTASQGHPEV QAPSQTGSPE AENGCGSPRE
310 320 330 340 350
ETTPGEHTDT GKATEGTASE ERVADEDRLG QKSPDANMPE EEGVVREKAP
360 370 380 390 400
QTSSGKAEGT TIAEPDTKQK EEAPLEPSCS PGADHAAGEI TSEIQNEKAV
410
SMDDIPIEDT RM
Length:412
Mass (Da):44,114
Last modified:October 11, 2005 - v1
Checksum:i650569CFA9083EFD
GO
Isoform 2 (identifier: Q3UZA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-65: Missing.

Show »
Length:382
Mass (Da):40,857
Checksum:i1F7997ED701C98F9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YXA9A0A0A6YXA9_MOUSE
CapZ-interacting protein
Rcsd1
34Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115V → I in AAH25872 (PubMed:15489334).Curated1
Sequence conflicti120S → G in BAE40643 (PubMed:16141072).Curated1
Sequence conflicti162R → K in BAE40643 (PubMed:16141072).Curated1
Sequence conflicti208A → P in AAH25872 (PubMed:15489334).Curated1
Sequence conflicti233W → R in BAE34505 (PubMed:16141072).Curated1
Sequence conflicti233W → R in BAE42730 (PubMed:16141072).Curated1
Sequence conflicti233W → R in AAH25872 (PubMed:15489334).Curated1
Sequence conflicti286T → I in BAE34505 (PubMed:16141072).Curated1
Sequence conflicti286T → I in BAE42730 (PubMed:16141072).Curated1
Sequence conflicti303T → A in AAH25872 (PubMed:15489334).Curated1
Sequence conflicti328R → S in BAE34505 (PubMed:16141072).Curated1
Sequence conflicti328R → S in BAE42730 (PubMed:16141072).Curated1
Sequence conflicti365P → R in BAE34505 (PubMed:16141072).Curated1
Sequence conflicti365P → R in BAE42730 (PubMed:16141072).Curated1
Sequence conflicti400V → A in BAE42392 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03164936 – 65Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133961 mRNA Translation: BAE21956.1
AK158429 mRNA Translation: BAE34505.1
AK168816 mRNA Translation: BAE40643.1
AK171323 mRNA Translation: BAE42392.1
AK171914 mRNA Translation: BAE42730.1
BC025872 mRNA Translation: AAH25872.1
CCDSiCCDS48425.1 [Q3UZA1-2]
CCDS48426.1 [Q3UZA1-1]
RefSeqiNP_001033935.1, NM_001038846.1 [Q3UZA1-2]
NP_848708.2, NM_178593.3 [Q3UZA1-1]
XP_006496846.1, XM_006496783.2 [Q3UZA1-1]
UniGeneiMm.265552
Mm.482459

Genome annotation databases

EnsembliENSMUST00000040357; ENSMUSP00000043724; ENSMUSG00000040723 [Q3UZA1-1]
ENSMUST00000097474; ENSMUSP00000095082; ENSMUSG00000040723 [Q3UZA1-2]
GeneIDi226594
KEGGimmu:226594
UCSCiuc007djj.1 mouse [Q3UZA1-1]
uc007djk.1 mouse [Q3UZA1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133961 mRNA Translation: BAE21956.1
AK158429 mRNA Translation: BAE34505.1
AK168816 mRNA Translation: BAE40643.1
AK171323 mRNA Translation: BAE42392.1
AK171914 mRNA Translation: BAE42730.1
BC025872 mRNA Translation: AAH25872.1
CCDSiCCDS48425.1 [Q3UZA1-2]
CCDS48426.1 [Q3UZA1-1]
RefSeqiNP_001033935.1, NM_001038846.1 [Q3UZA1-2]
NP_848708.2, NM_178593.3 [Q3UZA1-1]
XP_006496846.1, XM_006496783.2 [Q3UZA1-1]
UniGeneiMm.265552
Mm.482459

3D structure databases

ProteinModelPortaliQ3UZA1
SMRiQ3UZA1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230536, 2 interactors
STRINGi10090.ENSMUSP00000043724

PTM databases

iPTMnetiQ3UZA1
PhosphoSitePlusiQ3UZA1

Proteomic databases

EPDiQ3UZA1
PaxDbiQ3UZA1
PeptideAtlasiQ3UZA1
PRIDEiQ3UZA1

Protocols and materials databases

DNASUi226594
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040357; ENSMUSP00000043724; ENSMUSG00000040723 [Q3UZA1-1]
ENSMUST00000097474; ENSMUSP00000095082; ENSMUSG00000040723 [Q3UZA1-2]
GeneIDi226594
KEGGimmu:226594
UCSCiuc007djj.1 mouse [Q3UZA1-1]
uc007djk.1 mouse [Q3UZA1-2]

Organism-specific databases

CTDi92241
MGIiMGI:2676394 Rcsd1

Phylogenomic databases

eggNOGiENOG410IKAV Eukaryota
ENOG410YWC5 LUCA
GeneTreeiENSGT00510000049038
HOGENOMiHOG000049036
HOVERGENiHBG106582
InParanoidiQ3UZA1
KOiK18615
OMAiKETPACK
OrthoDBiEOG091G0DQJ
PhylomeDBiQ3UZA1
TreeFamiTF334159

Miscellaneous databases

ChiTaRSiRcsd1 mouse
PROiPR:Q3UZA1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040723 Expressed in 243 organ(s), highest expression level in thymus
CleanExiMM_RCSD1
ExpressionAtlasiQ3UZA1 baseline and differential
GenevisibleiQ3UZA1 MM

Family and domain databases

InterProiView protein in InterPro
IPR029341 FAM21/CAPZIP
IPR007850 RCSD
PfamiView protein in Pfam
PF15255 CAP-ZIP_m, 1 hit
PF05177 RCSD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPZIP_MOUSE
AccessioniPrimary (citable) accession number: Q3UZA1
Secondary accession number(s): Q3TAD8
, Q3TBC2, Q3TGA5, Q8R3A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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