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Protein

Pro-interleukin-16

Gene

Il16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation
Biological processChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-interleukin-16UniRule annotation
Cleaved into the following chain:
Interleukin-16UniRule annotation
Short name:
IL-16UniRule annotation
Alternative name(s):
Lymphocyte chemoattractant factorUniRule annotation
Short name:
LCFUniRule annotation
Gene namesi
Name:Il16Imported
Synonyms:IL16UniRule annotation
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1270855 Il16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation, SecretedUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ3UZ81

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ3UZ81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini407 – 492PDZInterPro annotationAdd BLAST86
Domaini528 – 611PDZInterPro annotationAdd BLAST84

Phylogenomic databases

eggNOGiKOG3528 Eukaryota
ENOG4110362 LUCA
HOVERGENiHBG000100

Family and domain databases

InterProiView protein in InterPro
IPR020450 IL-16
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PRINTSiPR01931 INTRLEUKIN16
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UZ81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYSFDITAE DPWVRISDCI KNLFSPIMSE NHSHTPLQPN TSLGEEDGTQ
60 70 80 90 100
GCPEGGLSKM DAANGAPRVY KSADGSTVKK GPPVAPKPAW FRQSLKGLRN
110 120 130 140 150
RAPDPRRPPE VASAIQPTPV SRDPPGPQPQ ASSSIRQRIS SFENFGSSQL
160 170 180 190 200
PDRGVQRLSL QPSSGETTKF PGKQDGGRFS GLLGQGATVT AKHRQTEVES
210 220 230 240 250
MSTTFPNSSE VRDPGLPESP PPGQRPSTKA LSPDPLLRLL TTQSEDTQGP
260 270 280 290 300
GLKMPSQRAR SFPLTRTQSC ETKLLDEKAS KLYSISSQLS SAVMKSLLCL
310 320 330 340 350
PSSVSCGQIT CIPKERVSPK SPCNNSSAAE GFGEAMASDT GFSLNLSELR
360 370 380 390 400
EYSEGLTEPG ETEDRNHCSS QAGQSVISLL SAEELEKLIE EVRVLDEATL
410 420 430 440 450
KQLDSIHVTI LHKEEGAGLG FSLAGGADLE NKVITVHRVF TNGLASQGGT
460 470 480 490 500
IQKGNEVLSI NGKSLKGATH NDALAILRQA RDPRQAVIVT RRTTVEATHD
510 520 530 540 550
LNSSTDSTAS ASAASDISVE SKEATVCTVT LEKTSAGLGF SLEGGKGSLH
560 570 580 590 600
GDKPLTINRI FKGTEQGEMV QPGDEILQLA GTAVQGLTRF EAWNVIKALP
610 620
DGPVTIVIRR TSLQCKQTTA SADS
Length:624
Mass (Da):66,433
Last modified:October 11, 2005 - v1
Checksum:i01EC116F349B816E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134007 mRNA Translation: BAE21977.1
UniGeneiMm.10137

Genome annotation databases

UCSCiuc009idt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134007 mRNA Translation: BAE21977.1
UniGeneiMm.10137

3D structure databases

ProteinModelPortaliQ3UZ81
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ3UZ81

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009idt.1 mouse

Organism-specific databases

MGIiMGI:1270855 Il16

Phylogenomic databases

eggNOGiKOG3528 Eukaryota
ENOG4110362 LUCA
HOVERGENiHBG000100

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR020450 IL-16
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PRINTSiPR01931 INTRLEUKIN16
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UZ81_MOUSE
AccessioniPrimary (citable) accession number: Q3UZ81
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: January 31, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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