UniProtKB - Q3UZ80 (Q3UZ80_MOUSE)
Protein
DNA nucleotidylexotransferase
Gene
Dntt
Organism
Mus musculus (Mouse)
Status
Functioni
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.UniRule annotation
Catalytic activityi
- a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)UniRule annotationARBA annotationEC:2.7.7.31UniRule annotationARBA annotation
Cofactori
Mg2+UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 343 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 345 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 434 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-directed DNA polymerase activity Source: UniProtKB-UniRule
- DNA nucleotidylexotransferase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA modification Source: UniProtKB-KW
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Terminal additionARBA annotation |
Ligand | MagnesiumUniRule annotation, Metal-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: DNA nucleotidylexotransferaseUniRule annotationARBA annotation (EC:2.7.7.31UniRule annotationARBA annotation) |
Gene namesi | Name:DnttImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:98659, Dntt |
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000025014, Expressed in thymus and 54 other tissues |
ExpressionAtlasi | Q3UZ80, baseline and differential |
Genevisiblei | Q3UZ80, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 118 | BRCTInterPro annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_008698_0_0_1 |
Family and domain databases
CDDi | cd00141, NT_POLXc, 1 hit |
Gene3Di | 1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.30.460.10, 1 hit 3.40.50.10190, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR002054, DNA-dir_DNA_pol_X IPR019843, DNA_pol-X_BS IPR010996, DNA_pol_b-like_N IPR028207, DNA_pol_B_palm_palm IPR018944, DNA_pol_lambd_fingers_domain IPR027421, DNA_pol_lamdba_lyase_dom_sf IPR037160, DNA_Pol_thumb_sf IPR022312, DNA_pol_X IPR043519, NT_sf IPR029398, PolB_thumb IPR027292, TdT IPR001726, TdT/Mu |
Pfami | View protein in Pfam PF00533, BRCT, 1 hit PF14792, DNA_pol_B_palm, 1 hit PF14791, DNA_pol_B_thumb, 1 hit PF10391, DNA_pol_lambd_f, 1 hit PF14716, HHH_8, 1 hit |
PIRSFi | PIRSF000817, DNA_NT, 1 hit PIRSF501175, TDT, 1 hit |
PRINTSi | PR00869, DNAPOLX PR00871, DNAPOLXTDT |
SMARTi | View protein in SMART SM00292, BRCT, 1 hit SM00483, POLXc, 1 hit |
SUPFAMi | SSF47802, SSF47802, 1 hit SSF52113, SSF52113, 1 hit SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit PS00522, DNA_POLYMERASE_X, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UZ80-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPLQAVHLG PRKKRPRQLG TPVASTPYDI RFRDLVLFIL EKKMGTTRRA
60 70 80 90 100
FLMELARRKG FRVENELSDS VTHIVAENNS GSDVLEWLQL QNIKASSELE
110 120 130 140 150
LLDISWLIEC MGAGKPVEMM GRHQLVVNRN SSPSPVPGSQ NVPAPAVKKI
160 170 180 190 200
SQYACQRRTT LNNYNQLFTD ALDILAENDE LRENEGSCLA FMRASSVLKS
210 220 230 240 250
LPFPITSMKD TEGIPCLGDK VKSIIEGIIE DGESSEAKAV LNDERYKSFK
260 270 280 290 300
LFTSVFGVGL KTAEKWFRMG FRTLSKIQSD KSLRFTQMQK AGFLYYEDLV
310 320 330 340 350
SCVNRPEAEA VSMLVKEAVV TFLPDALVTM TGGFRRGKMT GHDVDFLITS
360 370 380 390 400
PEATEDEEQQ LLHKVTDFWK QQGLLLYCDI LESTFEKFKQ PSRKVDALDH
410 420 430 440 450
FQKCFLILKL DHGRVHSEKS GQQEGKGWKA IRVDLVMCPY DRRAFALLGW
460 470 480 490 500
TGSRQFERDL RRYATHERKM MLDNHALYDR TKRVFLEAES EEEIFAHLGL
510
DYIEPWERNA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK134009 mRNA Translation: BAE21978.1 |
RefSeqi | NP_001036693.1, NM_001043228.1 |
Genome annotation databases
GeneIDi | 21673 |
KEGGi | mmu:21673 |
UCSCi | uc008hlp.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK134009 mRNA Translation: BAE21978.1 |
RefSeqi | NP_001036693.1, NM_001043228.1 |
3D structure databases
SMRi | Q3UZ80 |
ModBasei | Search... |
Proteomic databases
EPDi | Q3UZ80 |
MaxQBi | Q3UZ80 |
Protocols and materials databases
Antibodypediai | 16924, 563 antibodies |
DNASUi | 21673 |
Genome annotation databases
GeneIDi | 21673 |
KEGGi | mmu:21673 |
UCSCi | uc008hlp.1, mouse |
Organism-specific databases
CTDi | 1791 |
MGIi | MGI:98659, Dntt |
Phylogenomic databases
HOGENOMi | CLU_008698_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 21673, 7 hits in 19 CRISPR screens |
ChiTaRSi | Dntt, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025014, Expressed in thymus and 54 other tissues |
ExpressionAtlasi | Q3UZ80, baseline and differential |
Genevisiblei | Q3UZ80, MM |
Family and domain databases
CDDi | cd00141, NT_POLXc, 1 hit |
Gene3Di | 1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.30.460.10, 1 hit 3.40.50.10190, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR002054, DNA-dir_DNA_pol_X IPR019843, DNA_pol-X_BS IPR010996, DNA_pol_b-like_N IPR028207, DNA_pol_B_palm_palm IPR018944, DNA_pol_lambd_fingers_domain IPR027421, DNA_pol_lamdba_lyase_dom_sf IPR037160, DNA_Pol_thumb_sf IPR022312, DNA_pol_X IPR043519, NT_sf IPR029398, PolB_thumb IPR027292, TdT IPR001726, TdT/Mu |
Pfami | View protein in Pfam PF00533, BRCT, 1 hit PF14792, DNA_pol_B_palm, 1 hit PF14791, DNA_pol_B_thumb, 1 hit PF10391, DNA_pol_lambd_f, 1 hit PF14716, HHH_8, 1 hit |
PIRSFi | PIRSF000817, DNA_NT, 1 hit PIRSF501175, TDT, 1 hit |
PRINTSi | PR00869, DNAPOLX PR00871, DNAPOLXTDT |
SMARTi | View protein in SMART SM00292, BRCT, 1 hit SM00483, POLXc, 1 hit |
SUPFAMi | SSF47802, SSF47802, 1 hit SSF52113, SSF52113, 1 hit SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit PS00522, DNA_POLYMERASE_X, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UZ80_MOUSE | |
Accessioni | Q3UZ80Primary (citable) accession number: Q3UZ80 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |