UniProtKB - Q3UYK2 (Q3UYK2_MOUSE)
Protein
Presenilin
Gene
Psen1
Organism
Mus musculus (Mouse)
Status
Functioni
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.UniRule annotation
GO - Molecular functioni
- aspartic endopeptidase activity, intramembrane cleaving Source: Ensembl
- ATPase binding Source: Ensembl
- beta-catenin binding Source: Ensembl
- calcium channel activity Source: Ensembl
- growth factor receptor binding Source: Ensembl
- PDZ domain binding Source: Ensembl
GO - Biological processi
- amyloid-beta formation Source: Ensembl
- apoptotic process Source: UniProtKB-KW
- astrocyte activation involved in immune response Source: Ensembl
- cell-cell adhesion Source: Ensembl
- cellular response to amyloid-beta Source: Ensembl
- cellular response to DNA damage stimulus Source: Ensembl
- cerebellum development Source: Ensembl
- endoplasmic reticulum calcium ion homeostasis Source: Ensembl
- intracellular signal transduction Source: InterPro
- membrane protein ectodomain proteolysis Source: Ensembl
- memory Source: Ensembl
- modulation of age-related behavioral decline Source: Ensembl
- negative regulation of core promoter binding Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neural retina development Source: Ensembl
- neuron projection maintenance Source: Ensembl
- Notch receptor processing Source: Ensembl
- Notch signaling pathway Source: UniProtKB-KW
- positive regulation of amyloid fibril formation Source: Ensembl
- positive regulation of catalytic activity Source: Ensembl
- positive regulation of dendritic spine development Source: Ensembl
- positive regulation of glycolytic process Source: Ensembl
- positive regulation of protein binding Source: Ensembl
- positive regulation of protein import into nucleus Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- positive regulation of tumor necrosis factor production Source: Ensembl
- protein processing Source: Ensembl
- regulation of neuron projection development Source: Ensembl
- synapse organization Source: Ensembl
Keywordsi
Molecular function | Hydrolase, ProteaseUniRule annotation |
Biological process | ApoptosisARBA annotation, Cell adhesionARBA annotation, Notch signaling pathwayUniRule annotationARBA annotation |
Protein family/group databases
MEROPSi | A22.001 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Psen1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1202717, Psen1 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Endosome
- Early endosome membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Endosome membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- synapse ARBA annotation
- axon ARBA annotation
- neuron projection ARBA annotation
- Cytoplasmic granule ARBA annotation
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Cytoskeleton
- centrosome Source: Ensembl
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
- rough endoplasmic reticulum Source: Ensembl
- smooth endoplasmic reticulum Source: Ensembl
Endosome
- early endosome membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: Ensembl
Mitochondrion
- mitochondrial inner membrane Source: Ensembl
Nucleus
- nuclear outer membrane Source: Ensembl
- nucleoplasm Source: Ensembl
Plasma Membrane
- gamma-secretase complex Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
- sarcolemma Source: Ensembl
Other locations
- aggresome Source: Ensembl
- cell surface Source: Ensembl
- growth cone Source: Ensembl
- kinetochore Source: Ensembl
- membrane raft Source: Ensembl
- neuromuscular junction Source: Ensembl
- synaptic vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 82 – 100 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 133 – 154 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 161 – 183 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 195 – 213 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 225 – 241 | HelicalUniRule annotationAdd BLAST | 17 | |
Transmembranei | 247 – 263 | HelicalUniRule annotationAdd BLAST | 17 | |
Transmembranei | 408 – 428 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 434 – 453 | HelicalUniRule annotationAdd BLAST | 20 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Cell projectionARBA annotation, Endoplasmic reticulumUniRule annotationARBA annotation, Golgi apparatusUniRule annotationARBA annotation, Membrane, SynapseARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
MaxQBi | Q3UYK2 |
PRIDEi | Q3UYK2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000019969, Expressed in secondary oocyte and 320 other tissues |
ExpressionAtlasi | Q3UYK2, baseline and differential |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationGO - Molecular functioni
- ATPase binding Source: Ensembl
- beta-catenin binding Source: Ensembl
- growth factor receptor binding Source: Ensembl
- PDZ domain binding Source: Ensembl
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 68 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 304 – 357 | DisorderedSequence analysisAdd BLAST | 54 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 32 | PolarSequence analysisAdd BLAST | 32 | |
Compositional biasi | 33 – 47 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 304 – 328 | PolyampholyteSequence analysisAdd BLAST | 25 | |
Compositional biasi | 337 – 352 | PolyampholyteSequence analysisAdd BLAST | 16 |
Domaini
The PAL motif is required for normal active site conformation.UniRule annotation
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_022975_3_0_1 |
OMAi | YEARPVN |
OrthoDBi | 797738at2759 |
Family and domain databases
Gene3Di | 1.10.472.100, 1 hit |
InterProi | View protein in InterPro IPR002031, Pept_A22A_PS1 IPR001108, Peptidase_A22A IPR006639, Preselin/SPP IPR042524, Presenilin_C |
PANTHERi | PTHR10202, PTHR10202, 1 hit |
Pfami | View protein in Pfam PF01080, Presenilin, 1 hit |
PRINTSi | PR01072, PRESENILIN PR01073, PRESENILIN1 |
SMARTi | View protein in SMART SM00730, PSN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UYK2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEIPAPLSY FQNAQMSEDS HSSSAIRSQN DSQERQQQHD RQRLDNPEPI
60 70 80 90 100
SNGRPQSNSR QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI
110 120 130 140 150
KSVSFYTRKD GQLIYTPFTE DTETVGQRAL HSILNAAIMI SVIVIMTILL
160 170 180 190 200
VVLYKYRCYK VIHAWLIISS LLLLFFFSFI YLGEVFKTYN VAVDYVTVAL
210 220 230 240 250
LIWNFGVVGM IAIHWKGPLR LQQAYLIMIS ALMALVFIKY LPEWTAWLIL
260 270 280 290 300
AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE
310 320 330 340 350
GDPEAQRRVP KNPKYNTQRA ERETQDSGSG NDDGGFSEEW EAQRDSHLGP
360 370 380 390 400
HRSTPESRAA VQELSGSILT SEDPEERGVK LGLGDFIFYS VLVGKASATA
410 420 430 440 450
SGDWNTTIAC FVAILIGLCL TLLLLAIFKK ALPALPISIT FGLVFYFATD
460
YLVQPFMDQL AFHQFYI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK134232 mRNA Translation: BAE22058.1 AK134615 mRNA Translation: BAE22210.1 AK148101 mRNA Translation: BAE28344.1 AK165984 mRNA Translation: BAE38500.1 |
RefSeqi | NP_032969.1, NM_008943.2 XP_006515668.1, XM_006515605.3 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK134232 mRNA Translation: BAE22058.1 AK134615 mRNA Translation: BAE22210.1 AK148101 mRNA Translation: BAE28344.1 AK165984 mRNA Translation: BAE38500.1 |
RefSeqi | NP_032969.1, NM_008943.2 XP_006515668.1, XM_006515605.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | A22.001 |
Proteomic databases
MaxQBi | Q3UYK2 |
PRIDEi | Q3UYK2 |
Protocols and materials databases
Antibodypediai | 3480, 979 antibodies |
Organism-specific databases
MGIi | MGI:1202717, Psen1 |
Phylogenomic databases
HOGENOMi | CLU_022975_3_0_1 |
OMAi | YEARPVN |
OrthoDBi | 797738at2759 |
Miscellaneous databases
BioGRID-ORCSi | 19164, 2 hits in 52 CRISPR screens |
ChiTaRSi | Psen1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019969, Expressed in secondary oocyte and 320 other tissues |
ExpressionAtlasi | Q3UYK2, baseline and differential |
Family and domain databases
Gene3Di | 1.10.472.100, 1 hit |
InterProi | View protein in InterPro IPR002031, Pept_A22A_PS1 IPR001108, Peptidase_A22A IPR006639, Preselin/SPP IPR042524, Presenilin_C |
PANTHERi | PTHR10202, PTHR10202, 1 hit |
Pfami | View protein in Pfam PF01080, Presenilin, 1 hit |
PRINTSi | PR01072, PRESENILIN PR01073, PRESENILIN1 |
SMARTi | View protein in SMART SM00730, PSN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UYK2_MOUSE | |
Accessioni | Q3UYK2Primary (citable) accession number: Q3UYK2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | April 7, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |