Presenilin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• aspartic endopeptidase activity, intramembrane cleaving Source: Ensembl
• ATPase binding Source: Ensembl
• beta-catenin binding Source: Ensembl
• calcium channel activity Source: Ensembl
• growth factor receptor binding Source: Ensembl
• PDZ domain binding Source: Ensembl

GO - Biological processⁱ

• amyloid-beta formation Source: Ensembl
• apoptotic process Source: UniProtKB-KW
• astrocyte activation involved in immune response Source: Ensembl
• cell-cell adhesion Source: Ensembl
• cellular response to amyloid-beta Source: Ensembl
• cellular response to DNA damage stimulus Source: Ensembl
• cerebellum development Source: Ensembl
• endoplasmic reticulum calcium ion homeostasis Source: Ensembl
• intracellular signal transduction Source: InterPro
• membrane protein ectodomain proteolysis Source: Ensembl
• memory Source: Ensembl
• modulation of age-related behavioral decline Source: Ensembl
• negative regulation of core promoter binding Source: Ensembl
• negative regulation of neuron apoptotic process Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• neural retina development Source: Ensembl
• neuron projection maintenance Source: Ensembl
• Notch receptor processing Source: Ensembl
• Notch signaling pathway Source: UniProtKB-KW
• positive regulation of amyloid fibril formation Source: Ensembl
• positive regulation of catalytic activity Source: Ensembl
• positive regulation of dendritic spine development Source: Ensembl
• positive regulation of glycolytic process Source: Ensembl
• positive regulation of protein binding Source: Ensembl
• positive regulation of protein import into nucleus Source: Ensembl
• positive regulation of transcription, DNA-templated Source: Ensembl
• positive regulation of tumor necrosis factor production Source: Ensembl
• protein processing Source: Ensembl
• regulation of neuron projection development Source: Ensembl
• synapse organization Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• ATPase binding Source: Ensembl
• beta-catenin binding Source: Ensembl
• growth factor receptor binding Source: Ensembl
• PDZ domain binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTEIPAPLSY FQNAQMSEDS HSSSAIRSQN DSQERQQQHD RQRLDNPEPI 
        60         70         80         90        100
SNGRPQSNSR QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI 
       110        120        130        140        150
KSVSFYTRKD GQLIYTPFTE DTETVGQRAL HSILNAAIMI SVIVIMTILL 
       160        170        180        190        200
VVLYKYRCYK VIHAWLIISS LLLLFFFSFI YLGEVFKTYN VAVDYVTVAL 
       210        220        230        240        250
LIWNFGVVGM IAIHWKGPLR LQQAYLIMIS ALMALVFIKY LPEWTAWLIL 
       260        270        280        290        300
AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE 
       310        320        330        340        350
GDPEAQRRVP KNPKYNTQRA ERETQDSGSG NDDGGFSEEW EAQRDSHLGP 
       360        370        380        390        400
HRSTPESRAA VQELSGSILT SEDPEERGVK LGLGDFIFYS VLVGKASATA 
       410        420        430        440        450
SGDWNTTIAC FVAILIGLCL TLLLLAIFKK ALPALPISIT FGLVFYFATD 
       460 
YLVQPFMDQL AFHQFYI                                     

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ